STRINGSTRING
CBG05784 CBG05784 ruvb-2 ruvb-2 CBG06768 CBG06768 cya-1 cya-1 nola-3 nola-3 ctf-8 ctf-8 CBG28108 CBG28108 CBG26344 CBG26344 CBG23360 CBG23360 CBG23443 CBG23443 CBG22959 CBG22959 CBG22989 CBG22989 rfc-2 rfc-2 CBG22510 CBG22510 xnp-1 xnp-1 CBG21674 CBG21674 him-6 him-6 ruvb-1 ruvb-1 CBG19304 CBG19304 glo-4 glo-4 isw-1 isw-1 CBG07262 CBG07262 CBG26851 CBG26851 CBG26841 CBG26841 CBG26504 CBG26504 CBG27608 CBG27608 CBG07261 CBG07261 CBG08616 CBG08616 pri-2 pri-2 tcab-1 tcab-1 CBG09120 CBG09120 pph-6 pph-6 pri-1 pri-1 CBG10818 CBG10818 CBG11900 CBG11900 trt-1 trt-1 knl-2 knl-2 CBG23770 CBG23770 div-1 div-1 Cbr-rfc-4.1 Cbr-rfc-4.1 CBG15275 CBG15275 crn-1 crn-1 pcn-1 pcn-1 pola-1 pola-1 CBG12752 CBG12752 CBG01507 CBG01507 CBG20144 CBG20144 CBG24699 CBG24699 rpa-1 rpa-1 CBG18316 CBG18316 CBG18231 CBG18231 CBG13541 CBG13541 lin-53 lin-53 his-64 his-64 rfc-4 rfc-4 CBG01828 CBG01828 rfc-3 rfc-3 htz-1 htz-1 dna-2 dna-2 wrn-1 wrn-1 ctf-18 ctf-18 CBG03690 CBG03690 CBG03697 CBG03697 dscc-1 dscc-1 rfc-1 rfc-1 pif-1 pif-1 CBG06130 CBG06130
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG05784ATP-dependent DNA helicase; Belongs to the helicase family. (178 aa)
ruvb-2RuvB-like helicase; Belongs to the RuvB family. (447 aa)
CBG06768Protein CBG06768. (54 aa)
cya-1Protein CBG06936; Belongs to the cyclin family. (467 aa)
nola-3Protein CBR-NOLA-3. (118 aa)
ctf-8Protein CBG25323. (111 aa)
CBG28108Protein CBG28108. (74 aa)
CBG26344Protein CBG26344. (129 aa)
CBG23360DNA polymerase. (1081 aa)
CBG23443Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
CBG22959Serine/threonine-protein phosphatase. (551 aa)
CBG22989Protein CBG22989. (289 aa)
rfc-2Protein CBR-RFC-2. (329 aa)
CBG22510Protein CBG22510. (633 aa)
xnp-1Protein CBR-XNP-1. (1333 aa)
CBG21674Protein CBG21674. (171 aa)
him-6Protein CBR-HIM-6. (1005 aa)
ruvb-1RuvB-like helicase; Belongs to the RuvB family. (478 aa)
CBG19304Histone H2B; Belongs to the histone H2B family. (122 aa)
glo-4Protein CBR-GLO-4. (1392 aa)
isw-1Protein CBR-ISW-1. (1019 aa)
CBG07262ATP-dependent DNA helicase; Belongs to the helicase family. (494 aa)
CBG26851ATP-dependent DNA helicase; Belongs to the helicase family. (1306 aa)
CBG26841Protein CBG26841. (245 aa)
CBG26504Protein CBG26504. (279 aa)
CBG27608ATP-dependent DNA helicase; Belongs to the helicase family. (1081 aa)
CBG07261ATP-dependent DNA helicase; Belongs to the helicase family. (472 aa)
CBG08616Protein CBG08616. (86 aa)
pri-2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (512 aa)
tcab-1Protein CBG08747. (471 aa)
CBG09120Protein CBG09120. (380 aa)
pph-6Serine/threonine-protein phosphatase. (330 aa)
pri-1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
CBG10818Histone H2B; Belongs to the histone H2B family. (123 aa)
CBG11900ATP-dependent DNA helicase; Belongs to the helicase family. (523 aa)
trt-1Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (570 aa)
knl-2Protein CBR-KNL-2. (810 aa)
CBG23770Protein CBG23770. (299 aa)
div-1DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa)
Cbr-rfc-4.1Protein CBR-RFC-4.1. (340 aa)
CBG15275Protein CBG15275. (342 aa)
crn-1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (273 aa)
pola-1DNA polymerase. (1473 aa)
CBG12752Protein CBG12752. (546 aa)
CBG01507Histone H2B; Belongs to the histone H2B family. (122 aa)
CBG20144Protein CBG20144. (435 aa)
CBG24699Protein CBG24699. (319 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (658 aa)
CBG18316Putative H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family. (445 aa)
CBG18231Putative H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (163 aa)
CBG13541Probable H/ACA ribonucleoprotein complex subunit 1-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (246 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. (416 aa)
his-64Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rfc-4Protein CBR-RFC-4.2. (335 aa)
CBG01828Protein CBG01828. (433 aa)
rfc-3Protein CBR-RFC-3. (354 aa)
htz-1Histone H2A; Belongs to the histone H2A family. (142 aa)
dna-2Protein CBR-DNA-2. (1123 aa)
wrn-1Protein CBR-WRN-1. (1061 aa)
ctf-18Protein CBG03417. (840 aa)
CBG03690Protein CBG03690. (183 aa)
CBG03697Protein CBG03697. (249 aa)
dscc-1Protein CBG04176. (457 aa)
rfc-1Replication factor C subunit 1. (835 aa)
pif-1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (683 aa)
CBG06130Protein CBG06130. (450 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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