(44 nodes) Signaling by Insulin receptor network (Caenorhabditis briggsae)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	CBG24663	Protein CBG24663. (265 aa)
	CBG24990	Protein CBG24990. (330 aa)
	vha-9	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (121 aa)
	vha-5	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (888 aa)
	vha-4	Protein CBR-VHA-4. (214 aa)
	vha-6	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (867 aa)
	vha-7	Protein CBR-VHA-7. (1396 aa)
	vha-8	Protein CBR-VHA-8. (226 aa)
	unc-32	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (953 aa)
	nipi-3	Protein CBR-NIPI-3. (650 aa)
	pdk-1	Protein CBR-PDK-1. (644 aa)
	egl-17	Protein CBR-EGL-17; Belongs to the heparin-binding growth factors family. (214 aa)
	soc-1	Protein CBR-SOC-1. (510 aa)
	CBG09322	Protein CBG09322; Belongs to the peptidase M16 family. (1051 aa)
	vha-1	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (166 aa)
	Cbr-vha-16	Protein CBR-VHA-16. (292 aa)
	Cbr-tag-300	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (501 aa)
	vha-18	Probable V-type proton ATPase subunit H 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (451 aa)
	CBG14054	Protein CBG14054. (317 aa)
	CBG15451	Protein CBG15451. (183 aa)
	CBG15618	Protein CBG15618. (460 aa)
	CBG15660	Protein CBG15660; Belongs to the protein kinase superfamily. (299 aa)
	CBG15848	Protein CBG15848. (438 aa)
	CBG16624	Protein CBG16624. (700 aa)
	sem-5	Protein CBR-SEM-5. (229 aa)
	CBG17023	Protein CBG17023; Belongs to the peptidase M16 family. (618 aa)
	CBG18809	Protein CBG18809. (510 aa)
	CBG18810	Protein CBG18810. (567 aa)
	let-756	Protein CBR-LET-756; Belongs to the heparin-binding growth factors family. (473 aa)
	CBG20695	Protein CBG20695. (93 aa)
	vha-19	Protein CBR-VHA-19. (453 aa)
	CBG21176	Protein CBG21176. (174 aa)
	vha-17	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (86 aa)
	CBG23363	Protein CBG23363. (206 aa)
	CBG23102	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
	CBG25583	Protein CBG25583. (85 aa)
	vha-2	V-type proton ATPase 16 kDa proteolipid subunit 2; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The in [...] (161 aa)
	vha-3	V-type proton ATPase 16 kDa proteolipid subunit 3; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The in [...] (161 aa)
	vha-11	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Has roles in embryogenesis and ovulation (By similarity). (385 aa)
	vha-10	Probable V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death. (126 aa)
	vha-12	Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death and epidermal cell fusion (By similarity). Belongs to the ATPase alpha/beta chains family. (491 aa)
	vha-15	Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (470 aa)
	vha-14	V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity); Belongs to the V-ATPase D subunit family. (259 aa)
	vha-13	V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (By similarity). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (By similarity). The in [...] (606 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG14054	CBG15451	A8XJ94	A8XM94	Protein CBG14054.	Protein CBG15451.	0.718
CBG14054	CBG15848	A8XJ94	A8XMW4	Protein CBG14054.	Protein CBG15848.	0.811
CBG14054	CBG18809	A8XJ94	A8XU57	Protein CBG14054.	Protein CBG18809.	0.842
CBG14054	CBG18810	A8XJ94	A8XU58	Protein CBG14054.	Protein CBG18810.	0.842
CBG14054	CBG21176	A8XJ94	A8XZB6	Protein CBG14054.	Protein CBG21176.	0.718
CBG14054	CBG23102	A8XJ94	A8Y4P8	Protein CBG14054.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.891
CBG14054	CBG24663	A8XJ94	A8WL72	Protein CBG14054.	Protein CBG24663.	0.718
CBG14054	CBG24990	A8XJ94	A8WLX1	Protein CBG14054.	Protein CBG24990.	0.846
CBG14054	CBG25583	A8XJ94	B6IF70	Protein CBG14054.	Protein CBG25583.	0.825
CBG14054	Cbr-tag-300	A8XJ94	A8XBU8	Protein CBG14054.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.943
CBG14054	Cbr-vha-16	A8XJ94	A8XBU2	Protein CBG14054.	Protein CBR-VHA-16.	0.975
CBG14054	unc-32	A8XJ94	A8X399	Protein CBG14054.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.825
CBG14054	vha-1	A8XJ94	A8XA52	Protein CBG14054.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.845
CBG14054	vha-10	A8XJ94	Q617N0	Protein CBG14054.	Probable V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death.	0.957
CBG14054	vha-11	A8XJ94	Q612A4	Protein CBG14054.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Has roles in embryogenesis and ovulation (By similarity).	0.977
CBG14054	vha-12	A8XJ94	Q619C0	Protein CBG14054.	Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death and epidermal cell fusion (By similarity). Belongs to the ATPase alpha/beta chains family.	0.943
CBG14054	vha-13	A8XJ94	Q61VZ4	Protein CBG14054.	V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (By similarity). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (By similarity). The in [...]	0.972
CBG14054	vha-14	A8XJ94	Q61IU3	Protein CBG14054.	V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity); Belongs to the V-ATPase D subunit family.	0.969
CBG14054	vha-15	A8XJ94	Q619W9	Protein CBG14054.	Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).	0.901
CBG14054	vha-17	A8XJ94	A8Y0P5	Protein CBG14054.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.949