(52 nodes) RAB GEFs exchange GTP for GDP on RABs network (Caenorhabditis briggsae)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	unc-51	Protein CBR-UNC-51. (875 aa)
	CBG24636	Protein CBG24636. (770 aa)
	CBG00206	Protein CBG00206; Belongs to the protein kinase superfamily. (350 aa)
	CBG00556	Protein CBG00556. (363 aa)
	rab-1	Protein CBR-RAB-1. (205 aa)
	trpp-12	Protein CBG02113. (389 aa)
	rab-21	Protein CBR-RAB-21. (191 aa)
	CBG03022	Protein CBG03022. (1515 aa)
	rme-6	Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity). (1104 aa)
	CBG04321	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family. (401 aa)
	rab-6.1	Protein CBR-RAB-6.1. (205 aa)
	rab-14	Protein CBR-RAB-14. (210 aa)
	rbg-1	Protein CBR-RBG-1. (922 aa)
	aex-6	Protein CBR-AEX-6. (215 aa)
	CBG08107	Protein CBG08107. (328 aa)
	aex-3	Protein CBR-AEX-3. (1500 aa)
	sedl-1	Protein CBR-SEDL-1. (141 aa)
	zfp-3	Protein CBR-ZFP-3. (669 aa)
	rbg-2	Protein CBR-RBG-2. (1356 aa)
	jph-1	Protein CBR-JPH-1. (755 aa)
	CBG08571	Protein CBG08571. (395 aa)
	akt-1	Non-specific serine/threonine protein kinase. (605 aa)
	denn-4	Protein CBG10547. (1592 aa)
	lst-6	Protein CBG11204. (1506 aa)
	ccz-1	Protein CBR-CCZ-1. (530 aa)
	rin-1	Protein CBR-TAG-333. (1811 aa)
	rab-8	Protein CBR-RAB-8. (211 aa)
	rab-10	Protein CBR-RAB-10. (201 aa)
	rab-35	Protein CBR-RAB-35. (175 aa)
	CBG13932	Protein CBG13932. (534 aa)
	mtm-5	Protein CBR-MTM-5. (1776 aa)
	trpp-8	Protein CBG14902. (1272 aa)
	trpp-11	Protein CBG15291. (1142 aa)
	rep-1	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (532 aa)
	rab-6.2	Protein CBR-RAB-6.2. (205 aa)
	rme-4	Protein CBR-RME-4. (650 aa)
	trpp-9	Protein CBG17297. (1259 aa)
	CBG17299	Protein CBG17299. (1331 aa)
	CBG18350	Protein CBG18350. (121 aa)
	trpp-4	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (177 aa)
	trpp-6	Protein CBG19427. (185 aa)
	CBG19476	Protein CBG19476. (106 aa)
	sand-1	Protein CBR-SAND-1. (460 aa)
	CBG19958	Protein CBG19958. (572 aa)
	rab-39	Protein CBR-RAB-39. (199 aa)
	rab-7	Protein CBR-RAB-7. (209 aa)
	CBG21319	Protein CBG21319. (137 aa)
	gdi-1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (444 aa)
	coa-4	Protein CBG21696. (285 aa)
	CBG26760	Protein CBG26760. (113 aa)
	rab-18	Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). (202 aa)
	trpp-3	Trafficking protein particle complex subunit 3 homolog; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response. (181 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00556	gdi-1	A8WNL5	A8Y0A6	Protein CBG00556.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.732
CBG00556	rab-10	A8WNL5	A8XG73	Protein CBG00556.	Protein CBR-RAB-10.	0.961
CBG00556	rab-14	A8WNL5	A8X473	Protein CBG00556.	Protein CBR-RAB-14.	0.466
CBG00556	rab-39	A8WNL5	A8XXC6	Protein CBG00556.	Protein CBR-RAB-39.	0.694
CBG00556	rab-8	A8WNL5	A8XED7	Protein CBG00556.	Protein CBR-RAB-8.	0.961
CBG00556	rep-1	A8WNL5	A8XLN1	Protein CBG00556.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.503
CBG03022	CBG04321	A8WSZ2	A8WX89	Protein CBG03022.	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	0.404
CBG03022	gdi-1	A8WSZ2	A8Y0A6	Protein CBG03022.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.694
CBG03022	rab-1	A8WSZ2	A8WPI1	Protein CBG03022.	Protein CBR-RAB-1.	0.593
CBG03022	rab-6.1	A8WSZ2	A8X382	Protein CBG03022.	Protein CBR-RAB-6.1.	0.865
CBG03022	rab-6.2	A8WSZ2	A8XNF2	Protein CBG03022.	Protein CBR-RAB-6.2.	0.865
CBG03022	rep-1	A8WSZ2	A8XLN1	Protein CBG03022.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.593
CBG04321	CBG03022	A8WX89	A8WSZ2	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBG03022.	0.404
CBG04321	CBG08571	A8WX89	A8X737	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBG08571.	0.769
CBG04321	CBG17299	A8WX89	A8XQS6	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBG17299.	0.728
CBG04321	CBG21319	A8WX89	A8XZU1	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBG21319.	0.982
CBG04321	CBG26760	A8WX89	B6IED5	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBG26760.	0.832
CBG04321	rab-1	A8WX89	A8WPI1	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBR-RAB-1.	0.557
CBG04321	rep-1	A8WX89	A8XLN1	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.597
CBG04321	sedl-1	A8WX89	A8X604	Probable trafficking protein particle complex subunit 13 homolog; Belongs to the TRAPPC13 family.	Protein CBR-SEDL-1.	0.971