STRINGSTRING
kin-19 kin-19 skn-1 skn-1 spn-4 spn-4 pal-1 pal-1 mbk-2 mbk-2 gld-1 gld-1 ftn-1 ftn-1 tbx-35 tbx-35 pho-1 pho-1 pgp-2 pgp-2 unc-37 unc-37 mex-3 mex-3 pha-4 pha-4 hlh-6 hlh-6 gsk-3 gsk-3 elt-7 elt-7 wrm-1 wrm-1 ceh-22 ceh-22 pie-1 pie-1 cdk-1 cdk-1 unc-120 unc-120 peb-1 peb-1 elt-2 elt-2 pos-1a pos-1a pos-1 pos-1 ges-1 ges-1 mex-1 mex-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kin-19Protein CBR-KIN-19; Belongs to the protein kinase superfamily. (342 aa)
skn-1Protein CBR-SKN-1. (611 aa)
spn-4Protein CBR-SPN-4. (360 aa)
pal-1Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (271 aa)
mbk-2Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. (815 aa)
gld-1Protein CBR-GLD-1. (467 aa)
ftn-1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (170 aa)
tbx-35Protein CBR-TBX-35. (298 aa)
pho-1Protein CBR-PHO-1; Belongs to the histidine acid phosphatase family. (447 aa)
pgp-2Protein CBR-PGP-2. (1305 aa)
unc-37Protein CBR-UNC-37. (604 aa)
mex-3Protein CBR-MEX-3. (494 aa)
pha-4Protein CBR-PHA-4. (477 aa)
hlh-6Protein CBR-HLH-6. (144 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
elt-7Protein CBR-ELT-7. (195 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa)
ceh-22Protein CBR-CEH-22. (356 aa)
pie-1Protein CBR-PIE-1. (368 aa)
cdk-1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (326 aa)
unc-120Protein CBR-UNC-120. (319 aa)
peb-1Protein CBR-PEB-1. (432 aa)
elt-2Protein CBR-ELT-2. (445 aa)
pos-1aProtein CBG23753. (271 aa)
pos-1Protein CBR-POS-1. (263 aa)
ges-1Gut esterase 1; Belongs to the type-B carboxylesterase/lipase family. (562 aa)
mex-1Protein CBR-MEX-1. (425 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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