STRINGSTRING
mbk-2 mbk-2 spe-38 spe-38 CBG00175 CBG00175 emb-27 emb-27 cmd-1 cmd-1 fat-2 fat-2 cal-2 cal-2 ptp-2 ptp-2 cal-8 cal-8 mei-1 mei-1 rme-2 rme-2 efn-2 efn-2 spe-8 spe-8 efn-3 efn-3 cal-4 cal-4 egg-1 egg-1 spe-41 spe-41 cal-3 cal-3 vab-2 vab-2 CBG11013 CBG11013 pie-1 pie-1 chs-1 chs-1 mex-5 mex-5 egg-4 egg-4 spe-11 spe-11 CBG12886 CBG12886 spe-19 spe-19 spe-6 spe-6 vab-1 vab-1 cal-5 cal-5 spe-9 spe-9 cil-1 cil-1 cyk-4 cyk-4 swm-1 swm-1 cal-7 cal-7 egg-3 egg-3 oma-2 oma-2 taf-4 taf-4 CBG23534 CBG23534 cal-1 cal-1 efn-4 efn-4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mbk-2Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. (815 aa)
spe-38Protein CBG24396. (125 aa)
CBG00175Protein CBG00175. (172 aa)
emb-27Protein CBR-EMB-27. (669 aa)
cmd-1Protein CBR-CMD-1; Belongs to the calmodulin family. (149 aa)
fat-2Protein CBR-FAT-2. (376 aa)
cal-2Protein CBR-CAL-2. (171 aa)
ptp-2Protein CBR-PTP-2. (692 aa)
cal-8Protein CBG02410. (150 aa)
mei-1Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. This activity may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. (484 aa)
rme-2Protein CBR-RME-2. (929 aa)
efn-2Protein CBR-EFN-2; Belongs to the ephrin family. (219 aa)
spe-8Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites. (479 aa)
efn-3Protein CBR-EFN-3; Belongs to the ephrin family. (200 aa)
cal-4Protein CBR-CAL-4. (182 aa)
egg-1LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together [...] (636 aa)
spe-41Protein CBR-SPE-41. (807 aa)
cal-3Protein CBR-CAL-3. (233 aa)
vab-2Protein CBR-VAB-2; Belongs to the ephrin family. (242 aa)
CBG11013Protein CBG11013. (201 aa)
pie-1Protein CBR-PIE-1. (368 aa)
chs-1Protein CBR-CHS-1. (1319 aa)
mex-5Protein CBR-MEX-5. (474 aa)
egg-4Protein CBR-EGG-4. (752 aa)
spe-11Protein CBR-SPE-11. (289 aa)
CBG12886Protein CBG12886. (142 aa)
spe-19Protein CBR-SPE-19. (323 aa)
spe-6Protein CBR-SPE-6. (796 aa)
vab-1Protein CBR-VAB-1. (1118 aa)
cal-5Protein CBR-CAL-5. (156 aa)
spe-9Protein CBR-SPE-9. (658 aa)
cil-1Protein CBR-CIL-1. (398 aa)
cyk-4Protein CBR-CYK-4. (676 aa)
swm-1Protein CBR-SWM-1. (135 aa)
cal-7Protein CBG19361. (179 aa)
egg-3Protein CBR-EGG-3. (419 aa)
oma-2Protein CBR-OMA-2. (379 aa)
taf-4Protein CBR-TAF-4.1. (603 aa)
CBG23534Protein CBG23534. (201 aa)
cal-1Protein CBR-CAL-1. (161 aa)
efn-4Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis; Belongs to the ephrin family. (354 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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