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his-24 | Protein CBR-HIS-24. (198 aa) | ||||
mpk-1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa) | ||||
unc-79 | Protein CBR-UNC-79.2. (1163 aa) | ||||
plc-3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1308 aa) | ||||
plc-2 | Phosphoinositide phospholipase C. (933 aa) | ||||
plc-1 | Phosphoinositide phospholipase C. (1917 aa) | ||||
sem-5 | Protein CBR-SEM-5. (229 aa) | ||||
dpy-7 | Protein CBR-DPY-7. (319 aa) | ||||
lin-1 | Protein CBR-ELK-2. (411 aa) | ||||
daf-16 | Protein CBR-DAF-16. (497 aa) | ||||
sur-5 | Protein CBR-SUR-5. (691 aa) | ||||
aap-1 | Protein CBR-AAP-1. (522 aa) | ||||
tbg-1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (446 aa) | ||||
soc-1 | Protein CBR-SOC-1. (510 aa) | ||||
egl-17 | Protein CBR-EGL-17; Belongs to the heparin-binding growth factors family. (214 aa) | ||||
unc-32 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (953 aa) | ||||
plc-4 | Phosphoinositide phospholipase C. (752 aa) | ||||
lin-3 | Protein CBR-LIN-3. (450 aa) | ||||
let-60 | Protein CBR-LET-60. (184 aa) | ||||
egl-1 | Protein CBR-EGL-1. (110 aa) | ||||
ajm-1 | Protein CBR-AJM-1. (1478 aa) | ||||
rrf-3 | Protein CBR-RRF-3. (1766 aa) | ||||
let-23 | Receptor protein-tyrosine kinase. (1379 aa) | ||||
mek-2 | Protein CBR-MEK-2; Belongs to the protein kinase superfamily. (387 aa) | ||||
cep-1 | Transcription factor cep-1; Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Regulates germline apoptosis in response to DNA damage. Required for induction of ced-13 in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro (By [...] (658 aa) | ||||
lin-45 | Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1. (811 aa) | ||||
ced-4 | Cell death protein 4; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced- 3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During [...] (569 aa) | ||||
unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system (By similarity). Belongs to the PDE6D/unc-119 family. (217 aa) | ||||
ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (266 aa) | ||||
age-1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1159 aa) | ||||
sos-1 | Protein CBR-SOS-1. (339 aa) | ||||
ksr-1 | Protein CBR-KSR-1. (812 aa) |