STRINGSTRING
his-24 his-24 mpk-1 mpk-1 unc-79 unc-79 plc-3 plc-3 plc-2 plc-2 plc-1 plc-1 sem-5 sem-5 dpy-7 dpy-7 lin-1 lin-1 daf-16 daf-16 sur-5 sur-5 aap-1 aap-1 tbg-1 tbg-1 soc-1 soc-1 egl-17 egl-17 unc-32 unc-32 plc-4 plc-4 lin-3 lin-3 let-60 let-60 egl-1 egl-1 ajm-1 ajm-1 rrf-3 rrf-3 let-23 let-23 mek-2 mek-2 cep-1 cep-1 lin-45 lin-45 ced-4 ced-4 unc-119 unc-119 ced-9 ced-9 age-1 age-1 sos-1 sos-1 ksr-1 ksr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-24Protein CBR-HIS-24. (198 aa)
mpk-1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
unc-79Protein CBR-UNC-79.2. (1163 aa)
plc-31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1308 aa)
plc-2Phosphoinositide phospholipase C. (933 aa)
plc-1Phosphoinositide phospholipase C. (1917 aa)
sem-5Protein CBR-SEM-5. (229 aa)
dpy-7Protein CBR-DPY-7. (319 aa)
lin-1Protein CBR-ELK-2. (411 aa)
daf-16Protein CBR-DAF-16. (497 aa)
sur-5Protein CBR-SUR-5. (691 aa)
aap-1Protein CBR-AAP-1. (522 aa)
tbg-1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (446 aa)
soc-1Protein CBR-SOC-1. (510 aa)
egl-17Protein CBR-EGL-17; Belongs to the heparin-binding growth factors family. (214 aa)
unc-32V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (953 aa)
plc-4Phosphoinositide phospholipase C. (752 aa)
lin-3Protein CBR-LIN-3. (450 aa)
let-60Protein CBR-LET-60. (184 aa)
egl-1Protein CBR-EGL-1. (110 aa)
ajm-1Protein CBR-AJM-1. (1478 aa)
rrf-3Protein CBR-RRF-3. (1766 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
mek-2Protein CBR-MEK-2; Belongs to the protein kinase superfamily. (387 aa)
cep-1Transcription factor cep-1; Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Regulates germline apoptosis in response to DNA damage. Required for induction of ced-13 in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro (By [...] (658 aa)
lin-45Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1. (811 aa)
ced-4Cell death protein 4; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced- 3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During [...] (569 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system (By similarity). Belongs to the PDE6D/unc-119 family. (217 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (266 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1159 aa)
sos-1Protein CBR-SOS-1. (339 aa)
ksr-1Protein CBR-KSR-1. (812 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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