(42 nodes) (2015) The Homeobox Genes of Caenorhabditis elegans and Insights into Their Spatio-Temporal Expression Dynamics during Embryogenesis. network (Caenorhabditis briggsae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ceh-2	Protein CBR-CEH-2. (207 aa)
	unc-62	Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development (By similarity). Belongs to the TALE/MEIS homeobox family. (725 aa)
	pax-1	Protein CBR-PAX-1. (130 aa)
	egl-5	Protein CBR-EGL-5. (184 aa)
	eyg-1	Protein CBR-EYG-1. (312 aa)
	unc-4	Protein CBR-UNC-4. (251 aa)
	ceh-5	Protein CBR-CEH-5. (133 aa)
	zfh-2	Protein CBR-ZFH-2. (2140 aa)
	ceh-40	Protein CBG05292. (312 aa)
	ceh-79	Protein CBG06752. (495 aa)
	ceh-34	Protein CBR-CEH-34. (256 aa)
	psa-3	Protein CBR-PSA-3. (169 aa)
	dve-1	Protein CBR-DVE-1. (637 aa)
	nmy-2	Protein CBR-NMY-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2051 aa)
	ceh-45	Protein CBR-CEH-45. (232 aa)
	ceh-10	Protein CBR-CEH-10. (335 aa)
	ceh-13	Protein CBR-CEH-13. (202 aa)
	ceh-22	Protein CBR-CEH-22. (356 aa)
	ceh-44	Homeobox protein cut-like. (1537 aa)
	zag-1	Protein CBR-ZAG-1. (618 aa)
	pie-1	Protein CBR-PIE-1. (368 aa)
	lin-11	Protein CBR-LIN-11. (391 aa)
	ttx-1	Protein CBR-TTX-1. (367 aa)
	npax-2	Protein CBR-NPAX-2. (215 aa)
	ceh-30	Homeobox protein ceh-30; Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway (By similarity). (233 aa)
	ceh-63	Protein CBG14259. (171 aa)
	lim-4	Protein CBR-LIM-4. (346 aa)
	ceh-1	Protein CBR-CEH-1. (170 aa)
	mls-2	Protein CBR-MLS-2. (332 aa)
	ceh-37	Protein CBR-CEH-37. (287 aa)
	ceh-36	Protein CBR-CEH-36. (341 aa)
	ceh-20	Protein CBR-CEH-20. (338 aa)
	ceh-14	Protein CBR-CEH-14. (351 aa)
	pal-1	Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (271 aa)
	ceh-43	Protein CBR-CEH-43. (296 aa)
	nob-1	Protein CBG23031. (158 aa)
	php-3	Protein CBR-PHP-3. (269 aa)
	ceh-32	Protein CBR-CEH-32. (438 aa)
	ceh-23	Protein CBG26055. (300 aa)
	mec-3	Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (318 aa)
	mab-5	Protein CBR-MAB-5. (202 aa)
	lin-39	Protein CBR-LIN-39. (253 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ceh-1	lim-4	A8XK35	A8XJQ1	Protein CBR-CEH-1.	Protein CBR-LIM-4.	0.446
ceh-1	mec-3	A8XK35	P34764	Protein CBR-CEH-1.	Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.	0.417
ceh-10	ceh-14	A8X7U3	A8XPP0	Protein CBR-CEH-10.	Protein CBR-CEH-14.	0.432
ceh-10	ceh-20	A8X7U3	A8XPC3	Protein CBR-CEH-10.	Protein CBR-CEH-20.	0.540
ceh-10	ceh-32	A8X7U3	A8Y4A1	Protein CBR-CEH-10.	Protein CBR-CEH-32.	0.675
ceh-10	ceh-43	A8X7U3	A8XSY1	Protein CBR-CEH-10.	Protein CBR-CEH-43.	0.671
ceh-10	lim-4	A8X7U3	A8XJQ1	Protein CBR-CEH-10.	Protein CBR-LIM-4.	0.651
ceh-10	psa-3	A8X7U3	A8X4A0	Protein CBR-CEH-10.	Protein CBR-PSA-3.	0.767
ceh-13	ceh-20	A8X878	A8XPC3	Protein CBR-CEH-13.	Protein CBR-CEH-20.	0.878
ceh-13	ceh-40	A8X878	A8WZJ8	Protein CBR-CEH-13.	Protein CBG05292.	0.721
ceh-13	mec-3	A8X878	P34764	Protein CBR-CEH-13.	Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.	0.404
ceh-13	nob-1	A8X878	A8Y3E4	Protein CBR-CEH-13.	Protein CBG23031.	0.497
ceh-13	php-3	A8X878	A8Y3E5	Protein CBR-CEH-13.	Protein CBR-PHP-3.	0.533
ceh-13	unc-62	A8X878	A8WL06	Protein CBR-CEH-13.	Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development (By similarity). Belongs to the TALE/MEIS homeobox family.	0.495
ceh-14	ceh-10	A8XPP0	A8X7U3	Protein CBR-CEH-14.	Protein CBR-CEH-10.	0.432
ceh-14	ceh-30	A8XPP0	A8XJD0	Protein CBR-CEH-14.	Homeobox protein ceh-30; Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway (By similarity).	0.522
ceh-14	ceh-43	A8XPP0	A8XSY1	Protein CBR-CEH-14.	Protein CBR-CEH-43.	0.650
ceh-14	ceh-45	A8XPP0	A8X6R3	Protein CBR-CEH-14.	Protein CBR-CEH-45.	0.424
ceh-14	lim-4	A8XPP0	A8XJQ1	Protein CBR-CEH-14.	Protein CBR-LIM-4.	0.504
ceh-14	lin-11	A8XPP0	A8XEX4	Protein CBR-CEH-14.	Protein CBR-LIN-11.	0.494