STRINGSTRING
lin-48 lin-48 egl-5 egl-5 ajm-1 ajm-1 gld-1 gld-1 acr-14 acr-14 let-23 let-23 trr-1 trr-1 puf-2 puf-2 puf-1.1 puf-1.1 lin-49 lin-49 mod-5 mod-5 pop-1 pop-1 daf-12 daf-12 vab-3 vab-3 spe-8 spe-8 dmd-3 dmd-3 lin-3 lin-3 lin-12.2 lin-12.2 unc-46 unc-46 mab-23 mab-23 unc-47 unc-47 bar-1 bar-1 nurf-1 nurf-1 mom-2 mom-2 sea-1.2 sea-1.2 she-1 she-1 oig-1 oig-1 lin-59 lin-59 lin-44 lin-44 nath-10 nath-10 daf-16 daf-16 puf-8 puf-8 puf-1.2 puf-1.2 lin-32 lin-32 unc-25 unc-25 isw-1 isw-1 pry-1 pry-1 dbl-1 dbl-1 swm-1 swm-1 try-5 try-5 her-1 her-1 ces-2 ces-2 skn-1 skn-1 tra-3 tra-3 apx-1 apx-1 fem-2 fem-2 age-1 age-1 tra-2 tra-2 tra-1 tra-1 xol-1 xol-1 gpa-5 gpa-5 fog-1 fog-1 fem-3 fem-3 fog-3 fog-3 mab-5 mab-5 lin-39 lin-39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lin-48Protein CBR-LIN-48. (290 aa)
egl-5Protein CBR-EGL-5. (184 aa)
ajm-1Protein CBR-AJM-1. (1478 aa)
gld-1Protein CBR-GLD-1. (467 aa)
acr-14Protein CBR-ACR-14. (520 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
trr-1Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions. Required for spermatogenesis and embryonic development. Acts with tra-2 to promote expression of fog-3 and control male tail development. Involved in the negative regulation of vulval development (By similarity). (4115 aa)
puf-2Protein CBG02702. (493 aa)
puf-1.1Protein CBG02701. (766 aa)
lin-49Protein CBR-LIN-49. (1052 aa)
mod-5Protein CBR-MOD-5. (671 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage- derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. Belongs t [...] (439 aa)
daf-12Protein CBR-DAF-12. (758 aa)
vab-3Protein CBR-VAB-3. (290 aa)
spe-8Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites. (479 aa)
dmd-3Protein CBR-DMD-3. (252 aa)
lin-3Protein CBR-LIN-3. (450 aa)
lin-12.2Protein CBR-LIN-12. (1392 aa)
unc-46Protein CBR-UNC-46. (184 aa)
mab-23Protein CBR-MAB-23. (227 aa)
unc-47Protein CBR-UNC-47. (484 aa)
bar-1Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (808 aa)
nurf-1Protein CBR-NURF-1. (1674 aa)
mom-2Protein CBR-MOM-2. (358 aa)
sea-1.2Protein CBR-SEA-1. (566 aa)
she-1F-box protein she-1; Sex-determining factor which regulates hermaphrodite development. (830 aa)
oig-1Protein CBR-OIG-1. (85 aa)
lin-59Protein CBR-LIN-59. (1320 aa)
lin-44Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (341 aa)
nath-10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1077 aa)
daf-16Protein CBR-DAF-16. (497 aa)
puf-8Protein CBR-PUF-8. (535 aa)
puf-1.2Protein CBG13460. (593 aa)
lin-32Protein CBR-LIN-32. (148 aa)
unc-25Protein CBR-UNC-25. (510 aa)
isw-1Protein CBR-ISW-1. (1019 aa)
pry-1Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity (By similarity). (625 aa)
dbl-1Protein CBR-DBL-1. (373 aa)
swm-1Protein CBR-SWM-1. (135 aa)
try-5Protein CBR-TRY-5; Belongs to the peptidase S1 family. (305 aa)
her-1Protein CBR-HER-1. (174 aa)
ces-2Protein CBR-CES-2. (220 aa)
skn-1Protein CBR-SKN-1. (611 aa)
tra-3Protein CBR-TRA-3; Belongs to the peptidase C2 family. (646 aa)
apx-1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (484 aa)
fem-2Putative PP2C protein phosphatase FEM-2. (502 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1159 aa)
tra-2Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development (By similarity). In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1 (By similarity). Negatively regulates male development when bound to fem-3 and is required together with tra-1 for prom [...] (1489 aa)
tra-1Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development. Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determ [...] (1165 aa)
xol-1XO lethal protein 1 homolog; Belongs to the GHMP kinase family. Xol-1 subfamily. (426 aa)
gpa-5Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (385 aa)
fog-1Protein CBR-FOG-1. (647 aa)
fem-3Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. (409 aa)
fog-3Protein CBR-FOG-3. (261 aa)
mab-5Protein CBR-MAB-5. (202 aa)
lin-39Protein CBR-LIN-39. (253 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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