STRINGSTRING
bar-1 bar-1 cor-1 cor-1 lin-13 lin-13 lin-2 lin-2 let-23 let-23 cwn-2 cwn-2 egl-20 egl-20 sys-1 sys-1 mom-5 mom-5 lin-3 lin-3 lin-12.2 lin-12.2 lin-9 lin-9 cwn-1 cwn-1 wrm-1 wrm-1 lin-7 lin-7 dpy-10 dpy-10 mom-2 mom-2 smp-2 smp-2 lin-44 lin-44 lin-1 lin-1 mig-13 mig-13 hlh-8 hlh-8 lin-31 lin-31 lin-8 lin-8 smp-1 smp-1 mig-14 mig-14 apx-1 apx-1 lag-2 lag-2 lin-10 lin-10 CBG25001 CBG25001 mab-20 mab-20 plx-2 plx-2 lin-39 lin-39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bar-1Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (808 aa)
cor-1Coronin; Belongs to the WD repeat coronin family. (602 aa)
lin-13Protein CBR-LIN-13. (2294 aa)
lin-2Protein CBR-LIN-2; Belongs to the MAGUK family. (1009 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
cwn-2Protein CBR-CWN-2. (360 aa)
egl-20Protein CBR-EGL-20. (398 aa)
sys-1Protein CBR-SYS-1. (839 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
lin-3Protein CBR-LIN-3. (450 aa)
lin-12.2Protein CBR-LIN-12. (1392 aa)
lin-9Protein CBR-LIN-9. (641 aa)
cwn-1Protein CBR-CWN-1. (372 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa)
lin-7Protein CBR-LIN-7. (316 aa)
dpy-10Protein CBR-DPY-10. (810 aa)
mom-2Protein CBR-MOM-2. (358 aa)
smp-2Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
lin-44Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (341 aa)
lin-1Protein CBR-ELK-2. (411 aa)
mig-13Protein CBR-MIG-13. (360 aa)
hlh-8Protein CBR-HLH-8. (177 aa)
lin-31Protein CBR-LIN-31. (228 aa)
lin-8Protein CBR-LIN-8. (337 aa)
smp-1Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
mig-14Protein CBR-MIG-14. (548 aa)
apx-1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (484 aa)
lag-2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (392 aa)
lin-10Protein CBR-LIN-10, isoform a. (1120 aa)
CBG25001Coronin; Belongs to the WD repeat coronin family. (168 aa)
mab-20Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (656 aa)
plx-2Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. (1773 aa)
lin-39Protein CBR-LIN-39. (253 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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