STRINGSTRING
egl-43 egl-43 sdhb-1 sdhb-1 ced-3 ced-3 rict-1 rict-1 wrn-1 wrn-1 brc-1 brc-1 lin-35 lin-35 rad-51 rad-51 egl-1 egl-1 let-60 let-60 nhr-67 nhr-67 lin-40 lin-40 fos-1 fos-1 egl-27 egl-27 msh-2 msh-2 let-363 let-363 cdc-25.1 cdc-25.1 cki-1 cki-1 cku-70 cku-70 daf-18 daf-18 pvf-1 pvf-1 sem-5 sem-5 ver-3 ver-3 chk-2 chk-2 sftb-1 sftb-1 daf-15 daf-15 atm-1 atm-1 vps-34 vps-34 ksr-1 ksr-1 age-1 age-1 ced-9 ced-9 chk-1 chk-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
egl-43Protein CBR-EGL-43. (611 aa)
sdhb-1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa)
ced-3Protein CBR-CED-3; Belongs to the peptidase C14A family. (508 aa)
rict-1Protein CBG02784. (830 aa)
wrn-1Protein CBR-WRN-1. (1061 aa)
brc-1Protein CBR-BRC-1. (498 aa)
lin-35Protein CBR-LIN-35. (956 aa)
rad-51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (357 aa)
egl-1Protein CBR-EGL-1. (110 aa)
let-60Protein CBR-LET-60. (184 aa)
nhr-67Protein CBR-NHR-67. (423 aa)
lin-40Protein CBR-LIN-40. (1002 aa)
fos-1Protein CBR-FOS-1. (412 aa)
egl-27Protein CBR-EGL-27. (1151 aa)
msh-2Protein CBR-MSH-2. (847 aa)
let-363Serine/threonine-protein kinase TOR. (1721 aa)
cdc-25.1Protein CBR-CDC-25.1. (615 aa)
cki-1Protein CBR-CKI-1. (187 aa)
cku-70Protein CBR-CKU-70. (680 aa)
daf-18Protein CBR-DAF-18. (992 aa)
pvf-1Protein CBR-PVF-1. (300 aa)
sem-5Protein CBR-SEM-5. (229 aa)
ver-3Protein CBR-VER-3. (1313 aa)
chk-2Protein CBR-CHK-2. (289 aa)
sftb-1Protein CBG21228. (1272 aa)
daf-15Protein CBR-DAF-15. (1795 aa)
atm-1Protein CBR-ATM-1; Belongs to the PI3/PI4-kinase family. (639 aa)
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
ksr-1Protein CBR-KSR-1. (812 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1159 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (266 aa)
chk-1Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (493 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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