(28 nodes) Alanine, aspartate and glutamate metabolism network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	glna-3	Protein CBR-GLNA-3. (600 aa)
	asns-1	Protein CBR-ASNS-1. (572 aa)
	CBG01975	Protein CBG01975. (2174 aa)
	gfat-1	Protein CBG02850. (725 aa)
	gta-1	Protein CBR-GTA-1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (483 aa)
	CBG04059	Protein CBG04059. (504 aa)
	glna-1	Protein CBR-GLNA-1. (825 aa)
	ddo-2	D-aspartate oxidase 2; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells. Belongs to the DAMOX/DASOX family. (331 aa)
	got-2.2	Aspartate aminotransferase. (414 aa)
	ddo-1	Protein CBR-DDO-1. (337 aa)
	gdh-1	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (536 aa)
	alh-6	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
	adss-1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (435 aa)
	CBG12888	Protein CBG12888; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
	glna-2	Protein CBR-GLNA-2. (662 aa)
	gln-3	Glutamine synthetase. (385 aa)
	gln-1	Protein CBR-GLN-1; Belongs to the glutamine synthetase family. (385 aa)
	asns-2	Protein CBR-ASNS-2. (567 aa)
	unc-25	Protein CBR-UNC-25. (510 aa)
	got-1.2	Aspartate aminotransferase. (408 aa)
	Cbr-got-1.3	Protein CBR-GOT-1.3. (397 aa)
	ppat-1	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa)
	ddo-3	Protein CBR-DDO-3. (383 aa)
	Cbr-gln-5	Protein CBR-GLN-5; Belongs to the glutamine synthetase family. (383 aa)
	gln-2.1	Protein CBG20640; Belongs to the glutamine synthetase family. (367 aa)
	gln-2.2	Protein CBR-GLN-2; Belongs to the glutamine synthetase family. (367 aa)
	alh-7	Protein CBR-ALH-7; Belongs to the aldehyde dehydrogenase family. (499 aa)
	adsl-1	Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (478 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01975	CBG04059	A8WRQ4	A8WW42	Protein CBG01975.	Protein CBG04059.	0.573
CBG01975	Cbr-gln-5	A8WRQ4	A8XWM9	Protein CBG01975.	Protein CBR-GLN-5; Belongs to the glutamine synthetase family.	0.977
CBG01975	Cbr-got-1.3	A8WRQ4	A8XNT7	Protein CBG01975.	Protein CBR-GOT-1.3.	0.462
CBG01975	adsl-1	A8WRQ4	Q60Q90	Protein CBG01975.	Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.636
CBG01975	alh-6	A8WRQ4	A8X3N9	Protein CBG01975.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.921
CBG01975	asns-1	A8WRQ4	A8WQK1	Protein CBG01975.	Protein CBR-ASNS-1.	0.866
CBG01975	asns-2	A8WRQ4	A8XMA3	Protein CBG01975.	Protein CBR-ASNS-2.	0.866
CBG01975	gdh-1	A8WRQ4	A8X0P1	Protein CBG01975.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.999
CBG01975	gfat-1	A8WRQ4	A8WTD8	Protein CBG01975.	Protein CBG02850.	0.955
CBG01975	gln-1	A8WRQ4	A8XKR8	Protein CBG01975.	Protein CBR-GLN-1; Belongs to the glutamine synthetase family.	0.977
CBG01975	gln-2.1	A8WRQ4	A8XY98	Protein CBG01975.	Protein CBG20640; Belongs to the glutamine synthetase family.	0.977
CBG01975	gln-2.2	A8WRQ4	A8XYH6	Protein CBG01975.	Protein CBR-GLN-2; Belongs to the glutamine synthetase family.	0.977
CBG01975	gln-3	A8WRQ4	A8XIS2	Protein CBG01975.	Glutamine synthetase.	0.977
CBG01975	glna-1	A8WRQ4	A8WX31	Protein CBG01975.	Protein CBR-GLNA-1.	0.981
CBG01975	glna-2	A8WRQ4	A8XHY8	Protein CBG01975.	Protein CBR-GLNA-2.	0.981
CBG01975	glna-3	A8WRQ4	A8WJ54	Protein CBG01975.	Protein CBR-GLNA-3.	0.981
CBG01975	got-1.2	A8WRQ4	A8XNT6	Protein CBG01975.	Aspartate aminotransferase.	0.462
CBG01975	got-2.2	A8WRQ4	A8WYZ3	Protein CBG01975.	Aspartate aminotransferase.	0.471
CBG01975	ppat-1	A8WRQ4	A8XST9	Protein CBG01975.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.948
CBG01975	unc-25	A8WRQ4	A8XMQ1	Protein CBG01975.	Protein CBR-UNC-25.	0.913