(34 nodes) Tryptophan metabolism network (Caenorhabditis briggsae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	CBG24740	Protein CBG24740; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
	kat-1	Protein CBR-KAT-1; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	afmd-2	Protein CBG01758. (266 aa)
	CBG02861	Protein CBG02861. (370 aa)
	ech-9	Protein CBR-ECH-9. (448 aa)
	afmd-1	Protein CBG05817. (216 aa)
	hacd-1	Protein CBR-HACD-1. (298 aa)
	nkat-3	Protein CBR-NKAT-3. (441 aa)
	ech-7	Protein CBR-ECH-7; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
	alh-9	Protein CBR-ALH-9; Belongs to the aldehyde dehydrogenase family. (508 aa)
	tdo-2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (By similarity). Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (By similarity). (404 aa)
	bas-1	Protein CBR-BAS-1. (514 aa)
	alh-12	Protein CBR-ALH-12. (499 aa)
	CBG09979	Protein CBG09979; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa)
	ech-6	Protein CBR-ECH-6; Belongs to the enoyl-CoA hydratase/isomerase family. (288 aa)
	CBG10094	Protein CBG10094. (297 aa)
	nkat-1	Protein CBG10259. (425 aa)
	CBG10206	Protein CBG10206. (425 aa)
	alh-10	Protein CBR-ALH-10; Belongs to the aldehyde dehydrogenase family. (506 aa)
	acsd-1	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (355 aa)
	ech-1.2	Protein CBG12562. (755 aa)
	tph-1	Protein CBR-TPH-1. (546 aa)
	flu-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (483 aa)
	alh-11	Protein CBR-ALH-11; Belongs to the aldehyde dehydrogenase family. (684 aa)
	CBG16139	Protein CBG16139. (309 aa)
	alh-4	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (505 aa)
	CBG19218	Protein CBG19218. (1473 aa)
	ctl-1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (547 aa)
	ctl-2	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (500 aa)
	anmt-2	Protein CBG21119. (267 aa)
	alh-1	Protein CBR-ALH-1; Belongs to the aldehyde dehydrogenase family. (511 aa)
	ogdh-2	Protein CBG23406. (891 aa)
	kmo-1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
	haao-1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG02861	CBG09979	A8WTC7	A8XA31	Protein CBG02861.	Protein CBG09979; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
CBG02861	CBG10094	A8WTC7	A8XAD6	Protein CBG02861.	Protein CBG10094.	0.746
CBG02861	CBG16139	A8WTC7	A8XP12	Protein CBG02861.	Protein CBG16139.	0.746
CBG02861	CBG24740	A8WTC7	A8WLD3	Protein CBG02861.	Protein CBG24740; Belongs to the thiolase-like superfamily. Thiolase family.	0.743
CBG02861	acsd-1	A8WTC7	A8XDV4	Protein CBG02861.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.459
CBG02861	alh-1	A8WTC7	A8Y3G4	Protein CBG02861.	Protein CBR-ALH-1; Belongs to the aldehyde dehydrogenase family.	0.408
CBG02861	alh-10	A8WTC7	A8XBZ5	Protein CBG02861.	Protein CBR-ALH-10; Belongs to the aldehyde dehydrogenase family.	0.408
CBG02861	alh-11	A8WTC7	A8XLN9	Protein CBG02861.	Protein CBR-ALH-11; Belongs to the aldehyde dehydrogenase family.	0.408
CBG02861	alh-12	A8WTC7	A8X897	Protein CBG02861.	Protein CBR-ALH-12.	0.408
CBG02861	alh-4	A8WTC7	A8XUD6	Protein CBG02861.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.521
CBG02861	alh-9	A8WTC7	A8X7V5	Protein CBG02861.	Protein CBR-ALH-9; Belongs to the aldehyde dehydrogenase family.	0.449
CBG02861	ech-1.2	A8WTC7	A8XG18	Protein CBG02861.	Protein CBG12562.	0.968
CBG02861	ech-6	A8WTC7	A8XA54	Protein CBG02861.	Protein CBR-ECH-6; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
CBG02861	ech-7	A8WTC7	A8X7A3	Protein CBG02861.	Protein CBR-ECH-7; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
CBG02861	ech-9	A8WTC7	A8WUX8	Protein CBG02861.	Protein CBR-ECH-9.	0.697
CBG02861	hacd-1	A8WTC7	A8X2J7	Protein CBG02861.	Protein CBR-HACD-1.	0.743
CBG02861	kat-1	A8WTC7	A8WLD4	Protein CBG02861.	Protein CBR-KAT-1; Belongs to the thiolase-like superfamily. Thiolase family.	0.743
CBG02861	ogdh-2	A8WTC7	A8Y3Z6	Protein CBG02861.	Protein CBG23406.	0.929
CBG09979	CBG02861	A8XA31	A8WTC7	Protein CBG09979; Belongs to the enoyl-CoA hydratase/isomerase family.	Protein CBG02861.	0.967
CBG09979	CBG10094	A8XA31	A8XAD6	Protein CBG09979; Belongs to the enoyl-CoA hydratase/isomerase family.	Protein CBG10094.	0.981