(38 nodes) Sphingolipid metabolism network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG01383	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (522 aa)
	plpp-1.2	Protein CBG02670. (410 aa)
	cgt-3	Protein CBR-CGT-3. (467 aa)
	CBG04527	Protein CBG04527. (288 aa)
	plpp-1.3	Protein CBG04521. (304 aa)
	sms-1	Protein CBR-SMS-1. (407 aa)
	CBG05940	Protein CBG05940; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (360 aa)
	sptl-1	Protein CBR-SPTL-1. (451 aa)
	sms-2	Protein CBR-SMS-2. (336 aa)
	CBG08294	Protein CBG08294; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (438 aa)
	hpo-13	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (899 aa)
	ttm-5	Protein CBR-TTM-5; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (362 aa)
	CBG08882	Protein CBG08882. (441 aa)
	CBG10433	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (842 aa)
	spl-1	Protein CBR-SPL-1. (552 aa)
	bgal-2	Protein CBG10890. (1041 aa)
	sphk-1	Protein CBR-SPHK-1. (423 aa)
	asm-1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (562 aa)
	sptl-3	Protein CBR-SPTL-3. (513 aa)
	sptl-2	Protein CBR-SPTL-2. (588 aa)
	sms-3	Protein CBR-SMS-3. (297 aa)
	CBG12510	Protein CBG12510. (653 aa)
	cerk-1	Protein CBG12724. (550 aa)
	lagr-1	Protein CBR-LAGR-1. (360 aa)
	hyl-2	Protein CBR-HYL-2. (329 aa)
	asah-1	Protein CBR-ASAH-1; Belongs to the acid ceramidase family. (396 aa)
	CBG15382	Protein CBG15382; Belongs to the acid ceramidase family. (384 aa)
	hyl-1	Protein CBR-HYL-1. (349 aa)
	gba-1	Glucosylceramidase. (466 aa)
	gba-2	Glucosylceramidase. (518 aa)
	plpp-1.1	Protein CBG18435. (336 aa)
	spp-10	Protein CBR-SPP-10. (432 aa)
	spl-2	Protein CBR-TAG-38. (543 aa)
	gba-4	Glucosylceramidase. (519 aa)
	bgal-1	Beta-galactosidase. (675 aa)
	asah-2	Protein CBG00863; Belongs to the acid ceramidase family. (399 aa)
	CBG23831	Protein CBG23831. (223 aa)
	CBG18997	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. (272 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01383	CBG04527	A8WQA2	A8WXN9	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG04527.	0.900
CBG01383	CBG05940	A8WQA2	A8X1A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG05940; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.	0.900
CBG01383	CBG08882	A8WQA2	A8X7L9	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG08882.	0.902
CBG01383	CBG10433	A8WQA2	A8XB73	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.900
CBG01383	CBG12510	A8WQA2	A8XFX9	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG12510.	0.900
CBG01383	CBG15382	A8WQA2	A8XM26	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG15382; Belongs to the acid ceramidase family.	0.900
CBG01383	CBG18997	A8WQA2	Q60WT2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family.	0.900
CBG01383	asah-1	A8WQA2	A8XM25	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBR-ASAH-1; Belongs to the acid ceramidase family.	0.900
CBG01383	asah-2	A8WQA2	E3CTV6	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG00863; Belongs to the acid ceramidase family.	0.900
CBG01383	asm-1	A8WQA2	A8XCM9	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.900
CBG01383	cerk-1	A8WQA2	A8XGF4	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG12724.	0.901
CBG01383	cgt-3	A8WQA2	A8WU34	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBR-CGT-3.	0.902
CBG01383	gba-1	A8WQA2	A8XQC1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Glucosylceramidase.	0.900
CBG01383	gba-2	A8WQA2	A8XQC6	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Glucosylceramidase.	0.900
CBG01383	gba-4	A8WQA2	A8XWU0	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Glucosylceramidase.	0.900
CBG01383	hpo-13	A8WQA2	A8X7A9	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.900
CBG01383	hyl-1	A8WQA2	A8XMF5	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBR-HYL-1.	0.900
CBG01383	hyl-2	A8WQA2	A8XK42	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBR-HYL-2.	0.900
CBG01383	lagr-1	A8WQA2	A8XID0	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBR-LAGR-1.	0.900
CBG01383	plpp-1.1	A8WQA2	A8XTB0	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Protein CBG18435.	0.900