(10 nodes) One carbon pool by folate network (Caenorhabditis briggsae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Others

textmining

co-expression

protein homology

Your Input:
	alh-3	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	gcst-1	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
	CBG10863	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1019 aa)
	CBG12218	Protein CBG12218. (228 aa)
	dhfr-1	Protein CBG12356; Belongs to the dihydrofolate reductase family. (189 aa)
	CBG12961	Protein CBG12961. (278 aa)
	dao-3	Protein CBR-DAO-3. (301 aa)
	tyms-1	Protein CBG20269. (315 aa)
	metr-1	Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1273 aa)
	mel-32	Serine hydroxymethyltransferase; Interconversion of serine and glycine. (511 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG10863	CBG12218	A8XC59	A8XEZ0	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Protein CBG12218.	0.969
CBG10863	CBG12961	A8XC59	A8XGS0	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Protein CBG12961.	0.778
CBG10863	alh-3	A8XC59	A8X165	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.971
CBG10863	dao-3	A8XC59	A8XQ07	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Protein CBR-DAO-3.	0.999
CBG10863	dhfr-1	A8XC59	A8XF85	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Protein CBG12356; Belongs to the dihydrofolate reductase family.	0.979
CBG10863	gcst-1	A8XC59	A8X9C1	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.981
CBG10863	mel-32	A8XC59	Q60V73	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine.	0.999
CBG10863	metr-1	A8XC59	A8XY95	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).	0.962
CBG10863	tyms-1	A8XC59	A8XXD3	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Protein CBG20269.	0.710
CBG12218	CBG10863	A8XEZ0	A8XC59	Protein CBG12218.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.969
CBG12218	CBG12961	A8XEZ0	A8XGS0	Protein CBG12218.	Protein CBG12961.	0.471
CBG12218	dao-3	A8XEZ0	A8XQ07	Protein CBG12218.	Protein CBR-DAO-3.	0.989
CBG12218	dhfr-1	A8XEZ0	A8XF85	Protein CBG12218.	Protein CBG12356; Belongs to the dihydrofolate reductase family.	0.608
CBG12218	mel-32	A8XEZ0	Q60V73	Protein CBG12218.	Serine hydroxymethyltransferase; Interconversion of serine and glycine.	0.941
CBG12218	tyms-1	A8XEZ0	A8XXD3	Protein CBG12218.	Protein CBG20269.	0.420
CBG12961	CBG10863	A8XGS0	A8XC59	Protein CBG12961.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.778
CBG12961	CBG12218	A8XGS0	A8XEZ0	Protein CBG12961.	Protein CBG12218.	0.471
CBG12961	dao-3	A8XGS0	A8XQ07	Protein CBG12961.	Protein CBR-DAO-3.	0.978
CBG12961	dhfr-1	A8XGS0	A8XF85	Protein CBG12961.	Protein CBG12356; Belongs to the dihydrofolate reductase family.	0.647
CBG12961	gcst-1	A8XGS0	A8X9C1	Protein CBG12961.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.978