STRINGSTRING
CBG00175 CBG00175 let-23 let-23 cmd-1 cmd-1 mlck-1 mlck-1 ser-7 ser-7 mgl-2 mgl-2 cal-2 cal-2 cal-8 cal-8 nmr-1 nmr-1 mca-3 mca-3 CBG03436 CBG03436 trhr-1 trhr-1 Cbr-tag-316 Cbr-tag-316 npr-34 npr-34 unc-43 unc-43 gar-3 gar-3 tkr-2 tkr-2 plc-4 plc-4 vdac-1 vdac-1 egl-19 egl-19 ncx-2 ncx-2 CBG07728 CBG07728 ntr-2 ntr-2 csq-1 csq-1 cal-4 cal-4 tax-6 tax-6 cmk-1 cmk-1 cup-5 cup-5 mcu-1 mcu-1 CBG09342 CBG09342 cal-3 cal-3 lfe-2 lfe-2 CBG11013 CBG11013 sphk-1 sphk-1 CBG12886 CBG12886 ckr-1 ckr-1 ncx-1 ncx-1 cal-5 cal-5 ckr-2 ckr-2 stim-1 stim-1 CBG15711 CBG15711 ser-1 ser-1 pkc-2 pkc-2 CBG16677 CBG16677 CBG17210 CBG17210 plc-1 plc-1 sca-1 sca-1 acy-1 acy-1 plc-3 plc-3 cal-7 cal-7 kin-1 kin-1 mca-1 mca-1 ant-1.2 ant-1.2 CBG21094 CBG21094 ant-1.1 ant-1.1 mca-2 mca-2 CBG23534 CBG23534 cal-1 cal-1 cnb-1 cnb-1 itr-1 itr-1 orai-1 orai-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG00175Protein CBG00175. (172 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
cmd-1Protein CBR-CMD-1; Belongs to the calmodulin family. (149 aa)
mlck-1Protein CBG01967. (1205 aa)
ser-7Protein CBR-SER-7; Belongs to the G-protein coupled receptor 1 family. (427 aa)
mgl-2Protein CBR-MGL-2. (1083 aa)
cal-2Protein CBR-CAL-2. (171 aa)
cal-8Protein CBG02410. (150 aa)
nmr-1Protein CBR-NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1064 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1159 aa)
CBG03436Protein CBG03436; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
trhr-1Protein CBR-NMUR-4; Belongs to the G-protein coupled receptor 1 family. (397 aa)
Cbr-tag-316Protein CBR-TAG-316; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
npr-34Protein CBG04262; Belongs to the G-protein coupled receptor 1 family. (616 aa)
unc-43Calcium/calmodulin-dependent protein kinase type II; Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor (By simil [...] (533 aa)
gar-3Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family. (609 aa)
tkr-2Protein CBG05504; Belongs to the G-protein coupled receptor 1 family. (390 aa)
plc-4Phosphoinositide phospholipase C. (752 aa)
vdac-1Protein CBG05894. (283 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1780 aa)
ncx-2Protein CBR-NCX-2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (979 aa)
CBG07728Protein CBG07728. (928 aa)
ntr-2Protein CBG07660. (416 aa)
csq-1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (417 aa)
cal-4Protein CBR-CAL-4. (182 aa)
tax-6Serine/threonine-protein phosphatase. (532 aa)
cmk-1Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation. Transcriptional activation occurs at least in part through phosphorylation of crh-1. Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons. Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature. Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious [...] (356 aa)
cup-5Protein CBR-CUP-5. (650 aa)
mcu-1Protein CBR-MCU-1. (333 aa)
CBG09342Protein CBG09342; Belongs to the mitochondrial carrier (TC 2.A.29) family. (284 aa)
cal-3Protein CBR-CAL-3. (233 aa)
lfe-2Kinase; Belongs to the inositol phosphokinase (IPK) family. (393 aa)
CBG11013Protein CBG11013. (201 aa)
sphk-1Protein CBR-SPHK-1. (423 aa)
CBG12886Protein CBG12886. (142 aa)
ckr-1Protein CBR-CKR-1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
ncx-1Protein CBR-NCX-1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
cal-5Protein CBR-CAL-5. (156 aa)
ckr-2Protein CBR-CKR-2; Belongs to the G-protein coupled receptor 1 family. (602 aa)
stim-1Protein CBR-STIM-1. (550 aa)
CBG15711Protein CBG15711. (421 aa)
ser-1Protein CBR-SER-1; Belongs to the G-protein coupled receptor 1 family. (683 aa)
pkc-2Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (941 aa)
CBG16677Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1226 aa)
CBG17210Protein CBG17210; Belongs to the mitochondrial carrier (TC 2.A.29) family. (297 aa)
plc-1Phosphoinositide phospholipase C. (1917 aa)
sca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1081 aa)
acy-1Protein CBR-ACY-1. (1287 aa)
plc-31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1308 aa)
cal-7Protein CBG19361. (179 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. May play a role in the regulation of neuromuscular junctions. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily. (374 aa)
mca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1259 aa)
ant-1.2Protein CBG20451; Belongs to the mitochondrial carrier (TC 2.A.29) family. (216 aa)
CBG21094Protein CBG21094. (344 aa)
ant-1.1Protein CBR-TAG-61; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
mca-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1165 aa)
CBG23534Protein CBG23534. (201 aa)
cal-1Protein CBR-CAL-1. (161 aa)
cnb-1Protein CBR-CNB-1. (171 aa)
itr-1Protein CBR-ITR-1, isoform a. (2921 aa)
orai-1Protein orai; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function (By similarity); Belongs to the Orai family. (300 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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