(30 nodes) Mitophagy - animal network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	atg-9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (965 aa)
	fndc-1	Protein CBG02943. (137 aa)
	lgg-1	Protein lgg. (123 aa)
	fzo-1	Protein CBR-FZO-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (808 aa)
	kin-10	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (308 aa)
	let-60	Protein CBR-LET-60. (184 aa)
	jnk-1	Mitogen-activated protein kinase. (464 aa)
	atf-5	Protein CBR-ATF-5. (233 aa)
	ubq-1	Protein CBR-UBQ-1. (770 aa)
	fis-1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
	CBG12102	Protein CBG12102. (186 aa)
	tomm-7	Protein CBR-TOMM-7. (58 aa)
	kin-3	Protein CBR-KIN-3; Belongs to the protein kinase superfamily. (360 aa)
	daf-16	Protein CBR-DAF-16. (497 aa)
	kgb-1	Mitogen-activated protein kinase. (382 aa)
	CBG15218	Ubiquitin carboxyl-terminal hydrolase. (430 aa)
	ubq-2	Protein CBR-UBQ-2. (128 aa)
	dct-1	BNIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth (By similarity). Belongs to the NIP3 family. (220 aa)
	CBG17796	Protein CBG17796. (53 aa)
	pdr-1	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (385 aa)
	ras-2	Protein CBR-RAS-2. (211 aa)
	bec-1	Protein CBR-BEC-1. (375 aa)
	rab-7	Protein CBR-RAB-7. (209 aa)
	ras-1	Protein CBR-RAS-1. (211 aa)
	atg-5	Autophagy protein 5; Involved in autophagic vesicle formation. (287 aa)
	src-1	Tyrosine-protein kinase. (544 aa)
	fis-2	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
	CBG24924	Protein CBG24924. (389 aa)
	ubl-1	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. (163 aa)
	miro-1	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (637 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG12102	CBG15218	A8XER6	A8XLN0	Protein CBG12102.	Ubiquitin carboxyl-terminal hydrolase.	0.847
CBG12102	CBG17796	A8XER6	A8XRT8	Protein CBG12102.	Protein CBG17796.	0.952
CBG12102	fzo-1	A8XER6	A8WU50	Protein CBG12102.	Protein CBR-FZO-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.447
CBG12102	let-60	A8XER6	A8X0X5	Protein CBG12102.	Protein CBR-LET-60.	0.473
CBG12102	lgg-1	A8XER6	A8WTV5	Protein CBG12102.	Protein lgg.	0.402
CBG12102	pdr-1	A8XER6	A8XSA1	Protein CBG12102.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.987
CBG12102	src-1	A8XER6	A8Y1X2	Protein CBG12102.	Tyrosine-protein kinase.	0.413
CBG12102	ubl-1	A8XER6	P37164	Protein CBG12102.	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family.	0.998
CBG12102	ubq-1	A8XER6	A8X7Y8	Protein CBG12102.	Protein CBR-UBQ-1.	0.999
CBG12102	ubq-2	A8XER6	A8XMR9	Protein CBG12102.	Protein CBR-UBQ-2.	0.908
CBG15218	CBG12102	A8XLN0	A8XER6	Ubiquitin carboxyl-terminal hydrolase.	Protein CBG12102.	0.847
CBG15218	CBG17796	A8XLN0	A8XRT8	Ubiquitin carboxyl-terminal hydrolase.	Protein CBG17796.	0.847
CBG15218	miro-1	A8XLN0	Q623S8	Ubiquitin carboxyl-terminal hydrolase.	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.	0.846
CBG15218	pdr-1	A8XLN0	A8XSA1	Ubiquitin carboxyl-terminal hydrolase.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.517
CBG15218	ubl-1	A8XLN0	P37164	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family.	0.976
CBG15218	ubq-1	A8XLN0	A8X7Y8	Ubiquitin carboxyl-terminal hydrolase.	Protein CBR-UBQ-1.	0.948
CBG15218	ubq-2	A8XLN0	A8XMR9	Ubiquitin carboxyl-terminal hydrolase.	Protein CBR-UBQ-2.	0.847
CBG17796	CBG12102	A8XRT8	A8XER6	Protein CBG17796.	Protein CBG12102.	0.952
CBG17796	CBG15218	A8XRT8	A8XLN0	Protein CBG17796.	Ubiquitin carboxyl-terminal hydrolase.	0.847
CBG17796	fzo-1	A8XRT8	A8WU50	Protein CBG17796.	Protein CBR-FZO-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.447