STRINGSTRING
CBG00031 CBG00031 Cbr-skr-10 Cbr-skr-10 CBG00496 CBG00496 hsp-1 hsp-1 cdc-48.2 cdc-48.2 ufd-3 ufd-3 CBG00964 CBG00964 sar-1 sar-1 CBG02202 CBG02202 cup-2 cup-2 ostb-1 ostb-1 cdc-48.1 cdc-48.1 gcn-2 gcn-2 CBG02604 CBG02604 CBG02414 CBG02414 ufd-1 ufd-1 sec-24.2 sec-24.2 tram-1 tram-1 CBG03415 CBG03415 CBG03437 CBG03437 ubxn-1 ubxn-1 dnj-28 dnj-28 trap-1 trap-1 ile-1 ile-1 CBG03751 CBG03751 skr-1 skr-1 hrdl-1 hrdl-1 CBG04605 CBG04605 CBG04606 CBG04606 skr-20 skr-20 skr-19 skr-19 skr-21 skr-21 sec-24.1 sec-24.1 dnj-1 dnj-1 enpl-1 enpl-1 let-70 let-70 mogs-1 mogs-1 skr-16 skr-16 jnk-1 jnk-1 ribo-1 ribo-1 CBG06902 CBG06902 Cbr-npl-4.1 Cbr-npl-4.1 atf-5 atf-5 ubc-14 ubc-14 ile-2 ile-2 trap-2 trap-2 aagr-4 aagr-4 cdc-48.3 cdc-48.3 CBG08741 CBG08741 CBG08875 CBG08875 CBG08898 CBG08898 CBG09040 CBG09040 CBG09125 CBG09125 CBG09126 CBG09126 dnj-19 dnj-19 cnx-1 cnx-1 ubc-7 ubc-7 pdi-3 pdi-3 pdi-6 pdi-6 CBG10989 CBG10989 dnj-7 dnj-7 hsp-17 hsp-17 CBG11768 CBG11768 mans-1 mans-1 sec-12 sec-12 chn-1 chn-1 dad-1 dad-1 sec-23 sec-23 skr-17 skr-17 ubc-6 ubc-6 hsp-4 hsp-4 CBG13232 CBG13232 CBG13234 CBG13234 CBG13303 CBG13303 ufd-2 ufd-2 CBG13527 CBG13527 kgb-1 kgb-1 npp-20 npp-20 dnj-14 dnj-14 mans-3 mans-3 CBG14875 CBG14875 CBG14876 CBG14876 ostd-1 ostd-1 CBG15156 CBG15156 CBG15626 CBG15626 dnj-27 dnj-27 CBG16681 CBG16681 mek-1 mek-1 uggt-1 uggt-1 trap-3 trap-3 CBG16816 CBG16816 stt-3 stt-3 pdr-1 pdr-1 hsp-110 hsp-110 ubxn-4 ubxn-4 dnj-29 dnj-29 unc-23 unc-23 rbx-1 rbx-1 aagr-3 aagr-3 CBG19479 CBG19479 Cbr-ubc-15 Cbr-ubc-15 ero-1 ero-1 dnj-12 dnj-12 skn-1 skn-1 xbp-1 xbp-1 rnf-5 rnf-5 sec-61 sec-61 mans-4 mans-4 hsp-12.3 hsp-12.3 uggt-2 uggt-2 hsp-70 hsp-70 eif-2alpha eif-2alpha sel-1 sel-1 CBG23361 CBG23361 mans-2 mans-2 sel-11 sel-11 CBG00051 CBG00051 hsp-12.1 hsp-12.1 emo-1 emo-1 trap-4.1 trap-4.1 CBG13233 CBG13233 hsp-3 hsp-3 pdi-2 pdi-2 png-1 png-1 atx-3 atx-3 bag-1 bag-1 crt-1 crt-1 daf-21 daf-21 dnj-20 dnj-20 pdi-1 pdi-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG00031Protein CBG00031. (340 aa)
Cbr-skr-10Protein CBR-SKR-10; Belongs to the SKP1 family. (196 aa)
CBG00496Protein CBG00496; Belongs to the SKP1 family. (198 aa)
hsp-1Protein CBR-HSP-1; Belongs to the heat shock protein 70 family. (655 aa)
cdc-48.2Protein CBG00746; Belongs to the AAA ATPase family. (811 aa)
ufd-3Protein CBR-UFD-3. (896 aa)
CBG00964Protein CBG00964. (506 aa)
sar-1Protein CBG01701; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
CBG02202Protein CBG02202; Belongs to the SKP1 family. (174 aa)
cup-2Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (245 aa)
ostb-1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (445 aa)
cdc-48.1Protein CBG03070; Belongs to the AAA ATPase family. (865 aa)
gcn-2Protein CBG02792. (1692 aa)
CBG02604Protein CBG02604. (922 aa)
CBG02414Protein CBG02414; Belongs to the SKP1 family. (284 aa)
ufd-1Protein CBR-UFD-1. (341 aa)
sec-24.2Protein CBR-SEC-24.2. (1020 aa)
tram-1Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
CBG03415Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (182 aa)
CBG03437alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa)
ubxn-1Protein CBR-UBXN-1. (305 aa)
dnj-28Protein CBR-DNJ-28. (484 aa)
trap-1Protein CBR-TRAP-1. (257 aa)
ile-1Protein CBR-ILE-1. (491 aa)
CBG03751Protein CBG03751; Belongs to the heat shock protein 70 family. (689 aa)
skr-1Protein CBR-SKR-1; Belongs to the SKP1 family. (172 aa)
hrdl-1E3 ubiquitin-protein ligase hrd-like protein 1; Proposed to have a role in neuroprotection. (578 aa)
CBG04605Protein CBG04605; Belongs to the small heat shock protein (HSP20) family. (143 aa)
CBG04606Protein CBG04606; Belongs to the small heat shock protein (HSP20) family. (142 aa)
skr-20Protein CBR-SKR-20; Belongs to the SKP1 family. (165 aa)
skr-19Protein CBR-SKR-19; Belongs to the SKP1 family. (162 aa)
skr-21Protein CBR-SKR-21; Belongs to the SKP1 family. (166 aa)
sec-24.1Protein CBR-SEC-24.1. (1160 aa)
dnj-1Protein CBR-DNJ-1. (398 aa)
enpl-1Protein CBG06014. (776 aa)
let-70Protein CBR-LET-70; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
mogs-1Protein CBG05981. (788 aa)
skr-16Protein CBR-SKR-16; Belongs to the SKP1 family. (181 aa)
jnk-1Mitogen-activated protein kinase. (464 aa)
ribo-1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (586 aa)
CBG06902Protein CBG06902. (535 aa)
Cbr-npl-4.1Protein CBR-NPL-4.1. (527 aa)
atf-5Protein CBR-ATF-5. (233 aa)
ubc-14Protein CBR-UBC-14; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
ile-2Protein CBR-ILE-2. (347 aa)
trap-2Protein CBR-TRAP-2. (167 aa)
aagr-4Protein CBG08162; Belongs to the glycosyl hydrolase 31 family. (920 aa)
cdc-48.3Protein CBR-CDC-48.3. (736 aa)
CBG08741Protein CBG08741. (519 aa)
CBG08875Protein CBG08875. (619 aa)
CBG08898Protein CBG08898; Belongs to the SKP1 family. (161 aa)
CBG09040Protein CBG09040; Belongs to the SKP1 family. (186 aa)
CBG09125Protein CBG09125; Belongs to the SKP1 family. (197 aa)
CBG09126Protein CBG09126; Belongs to the SKP1 family. (203 aa)
dnj-19Protein CBR-DNJ-19. (433 aa)
cnx-1Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death (By similarity). (623 aa)
ubc-7Protein CBR-UBC-7; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
pdi-3Protein disulfide-isomerase. (488 aa)
pdi-6Protein CBR-TAG-320; Belongs to the protein disulfide isomerase family. (437 aa)
CBG10989Protein CBG10989; Belongs to the SKP1 family. (208 aa)
dnj-7Protein CBR-DNJ-7. (494 aa)
hsp-17Protein CBR-HSP-17; Belongs to the small heat shock protein (HSP20) family. (150 aa)
CBG11768Protein CBG11768; Belongs to the protein disulfide isomerase family. (438 aa)
mans-1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (541 aa)
sec-12Protein CBR-SEC-12. (423 aa)
chn-1Protein CBR-CHN-1. (266 aa)
dad-1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across th [...] (113 aa)
sec-23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (810 aa)
skr-17Protein CBR-SKR-17; Belongs to the SKP1 family. (177 aa)
ubc-6Protein CBR-UBC-6. (317 aa)
hsp-4Protein CBR-HSP-4; Belongs to the heat shock protein 70 family. (655 aa)
CBG13232Protein CBG13232. (248 aa)
CBG13234Protein CBG13234; Belongs to the heat shock protein 70 family. (629 aa)
CBG13303Protein CBG13303. (602 aa)
ufd-2Protein CBR-UFD-2. (1035 aa)
CBG13527Protein CBG13527. (212 aa)
kgb-1Mitogen-activated protein kinase. (382 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat; Belongs to the WD repeat SEC13 family. (306 aa)
dnj-14Protein CBR-DNJ-14. (224 aa)
mans-3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (589 aa)
CBG14875Protein CBG14875; Belongs to the SKP1 family. (154 aa)
CBG14876Protein CBG14876; Belongs to the SKP1 family. (149 aa)
ostd-1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (284 aa)
CBG15156Protein CBG15156; Belongs to the SKP1 family. (335 aa)
CBG15626Protein CBG15626; Belongs to the SKP1 family. (208 aa)
dnj-27Protein CBR-DNJ-27. (783 aa)
CBG16681Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (616 aa)
mek-1Protein CBR-MEK-1. (463 aa)
uggt-1Protein CBG16703. (1495 aa)
trap-3Protein CBR-TRAP-3. (178 aa)
CBG16816Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (80 aa)
stt-3Protein CBG17485. (762 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (385 aa)
hsp-110Protein CBG18133. (777 aa)
ubxn-4Protein CBR-UBXN-4. (456 aa)
dnj-29Protein CBR-DNJ-29. (760 aa)
unc-23Protein CBR-UNC-23. (457 aa)
rbx-1Protein CBR-RBX-1. (110 aa)
aagr-3Protein CBG19359; Belongs to the glycosyl hydrolase 31 family. (924 aa)
CBG19479Protein CBG19479; Belongs to the heat shock protein 70 family. (561 aa)
Cbr-ubc-15Protein CBR-UBC-15. (578 aa)
ero-1Protein CBR-ERO-1. (501 aa)
dnj-12Protein CBR-DNJ-12. (401 aa)
skn-1Protein CBR-SKN-1. (611 aa)
xbp-1Protein CBR-XBP-1. (331 aa)
rnf-5Protein CBR-RNF-5. (241 aa)
sec-61Protein CBG21508. (473 aa)
mans-4alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (527 aa)
hsp-12.3Protein CBR-HSP-12.3; Belongs to the small heat shock protein (HSP20) family. (109 aa)
uggt-2Protein CBG22023. (1280 aa)
hsp-70Protein CBR-HSP-70; Belongs to the heat shock protein 70 family. (651 aa)
eif-2alphaProtein CBG22041. (342 aa)
sel-1Protein CBR-SEL-1. (685 aa)
CBG23361alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (775 aa)
mans-2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (575 aa)
sel-11E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...] (622 aa)
CBG00051Protein CBG00051. (907 aa)
hsp-12.1Protein CBG02254; Belongs to the small heat shock protein (HSP20) family. (109 aa)
emo-1Protein CBR-EMO-1. (68 aa)
trap-4.1Protein CBR-TRAP-4.1. (159 aa)
CBG13233Protein CBG13233; Belongs to the heat shock protein 70 family. (585 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
pdi-2Protein disulfide-isomerase. (493 aa)
png-1Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] (602 aa)
atx-3Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] (319 aa)
bag-1BAG family molecular chaperone regulator 1; May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner. (209 aa)
crt-1Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress- induced neurodegeneration (By similarity). (396 aa)
daf-21Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (706 aa)
dnj-20DnaJ homolog dnj-20. (382 aa)
pdi-1Protein disulfide-isomerase. (481 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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