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asm-1 | Sphingomyelin phosphodiesterase 1; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (564 aa) | ||||
hyl-1 | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. (372 aa) | ||||
C29E4.10 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. (645 aa) | ||||
gba-1 | Putative glucosylceramidase 1. (523 aa) | ||||
gba-2 | Putative glucosylceramidase 2; Belongs to the glycosyl hydrolase 30 family. (516 aa) | ||||
cgt-2 | Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. (443 aa) | ||||
asah-2 | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (401 aa) | ||||
sms-2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. (335 aa) | ||||
cgt-3 | Ceramide glucosyltransferase 3; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode. (470 aa) | ||||
sms-1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. (469 aa) | ||||
hyl-2 | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. (329 aa) | ||||
R05D11.9 | Uncharacterized protein. (640 aa) | ||||
R08F11.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (819 aa) | ||||
cgt-1 | Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. (466 aa) | ||||
cerk-1 | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. (549 aa) | ||||
T27F6.6 | Putative neutral sphingomyelinase. (434 aa) | ||||
W02F12.2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. (272 aa) | ||||
asm-3 | Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (589 aa) | ||||
hpo-13 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (959 aa) | ||||
sms-3 | Putative phosphatidylcholine:ceramide cholinephosphotransferase 3; Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity). (425 aa) | ||||
gba-4 | Putative glucosylceramidase 4; Belongs to the glycosyl hydrolase 30 family. (519 aa) | ||||
ttm-5 | Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. (362 aa) | ||||
lagr-1 | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. (360 aa) | ||||
asm-2 | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (618 aa) |