| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C29E4.10 | T27F6.6 | C29E4.10.1 | T27F6.6.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative neutral sphingomyelinase. | 0.907 |
| C29E4.10 | W02F12.2 | C29E4.10.1 | W02F12.2.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.916 |
| C29E4.10 | asah-2 | C29E4.10.1 | F27E5.1.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.980 |
| C29E4.10 | asm-3 | C29E4.10.1 | W03G1.7a.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.916 |
| C29E4.10 | cerk-1 | C29E4.10.1 | T10B11.2.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.936 |
| C29E4.10 | hyl-1 | C29E4.10.1 | C09G4.1b.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.906 |
| C29E4.10 | hyl-2 | C29E4.10.1 | K02G10.6.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.923 |
| C29E4.10 | lagr-1 | C29E4.10.1 | Y6B3B.10.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.906 |
| C29E4.10 | sms-1 | C29E4.10.1 | H21P03.3b.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.933 |
| C29E4.10 | sms-3 | C29E4.10.1 | Y22D7AL.8b.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative phosphatidylcholine:ceramide cholinephosphotransferase 3; Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity). | 0.906 |
| T27F6.6 | C29E4.10 | T27F6.6.1 | C29E4.10.1 | Putative neutral sphingomyelinase. | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | 0.907 |
| T27F6.6 | W02F12.2 | T27F6.6.1 | W02F12.2.1 | Putative neutral sphingomyelinase. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.956 |
| T27F6.6 | asah-2 | T27F6.6.1 | F27E5.1.1 | Putative neutral sphingomyelinase. | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.966 |
| T27F6.6 | asm-3 | T27F6.6.1 | W03G1.7a.1 | Putative neutral sphingomyelinase. | Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. | 0.933 |
| T27F6.6 | cerk-1 | T27F6.6.1 | T10B11.2.1 | Putative neutral sphingomyelinase. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.937 |
| T27F6.6 | hyl-1 | T27F6.6.1 | C09G4.1b.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.934 |
| T27F6.6 | hyl-2 | T27F6.6.1 | K02G10.6.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.962 |
| T27F6.6 | lagr-1 | T27F6.6.1 | Y6B3B.10.1 | Putative neutral sphingomyelinase. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.979 |
| T27F6.6 | sms-1 | T27F6.6.1 | H21P03.3b.1 | Putative neutral sphingomyelinase. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.940 |
| T27F6.6 | sms-3 | T27F6.6.1 | Y22D7AL.8b.1 | Putative neutral sphingomyelinase. | Putative phosphatidylcholine:ceramide cholinephosphotransferase 3; Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity). | 0.936 |