STRINGSTRING
rga-9 rga-9 chin-1 chin-1 magu-2 magu-2 pac-1 pac-1 pak-1 pak-1 C09G1.4 C09G1.4 ced-10 ced-10 let-502 let-502 tiam-1 tiam-1 cgef-1 cgef-1 ajm-1 ajm-1 rap-2 rap-2 dlg-1 dlg-1 crb-3 crb-3 mig-2 mig-2 C36E8.4 C36E8.4 tag-325 tag-325 pak-2 pak-2 magu-3 magu-3 mpz-1 mpz-1 cav-2 cav-2 pkc-3 pkc-3 git-1 git-1 chw-1 chw-1 F22E12.3 F22E12.3 let-413 let-413 picc-1 picc-1 rhi-1 rhi-1 par-3 par-3 unc-73 unc-73 klp-4 klp-4 lgl-1 lgl-1 par-2 par-2 rga-5 rga-5 eat-20 eat-20 par-1 par-1 magi-1 magi-1 rac-2 rac-2 hmp-2 hmp-2 mrck-1 mrck-1 K08E3.2 K08E3.2 pix-1 pix-1 osg-1 osg-1 cdc-42 cdc-42 hmp-1 hmp-1 rhgf-2 rhgf-2 cav-1 cav-1 ppm-2 ppm-2 T26C12.3 T26C12.3 par-6 par-6 bath-35 bath-35 rga-1 rga-1 hmr-1 hmr-1 afd-1 afd-1 jac-1 jac-1 Y105E8A.25 Y105E8A.25 zoo-1 zoo-1 crp-1 crp-1 rga-8 rga-8 max-2 max-2 rho-1 rho-1 rga-2 rga-2 magu-1 magu-1 Y67D8C.22 Y67D8C.22 rga-4 rga-4 src-1 src-1 nck-1 nck-1 spv-1 spv-1 ZK970.8 ZK970.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rga-9Rho-GAP domain-containing protein. (478 aa)
chin-1CHImaeriN (Rac-GTPase-activating protein) homolog. (421 aa)
magu-2MAGUK family; Belongs to the MAGUK family. (830 aa)
pac-1GTPase-activating protein pac-1; GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60. Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6. Required for blastomere polarization. (1718 aa)
pak-1Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] (572 aa)
C09G1.4Uncharacterized protein C09G1.4. (545 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
let-502Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization. (1173 aa)
tiam-1DH domain-containing protein. (889 aa)
cgef-1DH domain-containing protein. (1055 aa)
ajm-1Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. (1905 aa)
rap-2RAP homolog (Vertebrate Rap GTPase family). (181 aa)
dlg-1Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. (967 aa)
crb-3Drosophila CRumBs homolog. (100 aa)
mig-2Rac-like GTPase. (195 aa)
C36E8.4Uncharacterized protein. (548 aa)
tag-325WW domain-containing protein tag-325. (840 aa)
pak-2Serine/threonine-protein kinase pak-2; Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. (522 aa)
magu-3Guanylate kinase-like domain-containing protein. (479 aa)
mpz-1Multiple PDZ domain protein. (2491 aa)
cav-2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa)
git-1GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa)
chw-1CHp/Wrch Rho-like protein homolog. (207 aa)
F22E12.3Uncharacterized protein. (252 aa)
let-413Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] (699 aa)
picc-1PAC-1 interacting and coiled-coil domain-containing protein 1; Linker protein which helps to recruit the Rho GTPase- activating protein, pac-1, to adherens junctions. (535 aa)
rhi-1Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (191 aa)
par-3Partitioning defective protein 3; In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo. Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces. Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca. Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first [...] (1533 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
klp-4Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1610 aa)
lgl-1LLGL domain-containing protein. (941 aa)
par-2RING-type domain-containing protein. (582 aa)
rga-5Rho-GAP domain-containing protein. (1341 aa)
eat-20Abnormal pharyngeal pumping eat-20; Regulates pharyngeal pumping during feeding. (810 aa)
par-1Serine/threonine-protein kinase par-1; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Involved in the establishment of neuronal polarity. (1216 aa)
magi-1MAGI (Membrane Associated Guanylate kinase Inverted) homolog. (1054 aa)
rac-2Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa)
hmp-2Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. (704 aa)
mrck-1Serine/threonine-protein kinase mrck-1; Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation. (1592 aa)
K08E3.2Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (276 aa)
pix-1PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa)
osg-1Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
hmp-1Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. (930 aa)
rhgf-2DH domain-containing protein. (1149 aa)
cav-1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa)
ppm-2Probable protein phosphatase 2C T23F11.1. (356 aa)
T26C12.3RING-type domain-containing protein. (345 aa)
par-6Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family. (309 aa)
bath-35BTB domain-containing protein. (266 aa)
rga-1Rho-GAP domain-containing protein. (444 aa)
hmr-1Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton. Isoform b is involved in axonal guidance in a subset of motor neurons. (2920 aa)
afd-1PDZ domain-containing protein. (1660 aa)
jac-1Juxtamembrane domain-associated catenin; May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the beta-catenin family. (1256 aa)
Y105E8A.25DH domain-containing protein. (1619 aa)
zoo-1ZO-1 (Zonula Occludens tight junctional protein) Ortholog. (1172 aa)
crp-1Cdc-42 Related Protein. (187 aa)
rga-8Rho-GAP domain-containing protein. (709 aa)
max-2Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
rga-2Rho GTPase Activating protein. (908 aa)
magu-1MAGUK family. (567 aa)
Y67D8C.22Uncharacterized protein. (225 aa)
rga-4Rho-GAP domain-containing protein. (1135 aa)
src-1Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...] (537 aa)
nck-1NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. (395 aa)
spv-1Spermathecal Physiology Variant. (966 aa)
ZK970.8Uncharacterized protein. (143 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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