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rga-9 | Rho-GAP domain-containing protein. (478 aa) | ||||
chin-1 | CHImaeriN (Rac-GTPase-activating protein) homolog. (421 aa) | ||||
pak-1 | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] (572 aa) | ||||
ced-10 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa) | ||||
let-502 | Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization. (1173 aa) | ||||
tiam-1 | DH domain-containing protein. (889 aa) | ||||
cgef-1 | DH domain-containing protein. (1055 aa) | ||||
rap-2 | RAP homolog (Vertebrate Rap GTPase family). (181 aa) | ||||
mig-2 | Rac-like GTPase. (195 aa) | ||||
tag-325 | WW domain-containing protein tag-325. (840 aa) | ||||
pak-2 | Serine/threonine-protein kinase pak-2; Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. (522 aa) | ||||
cav-2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa) | ||||
git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) | ||||
rhi-1 | Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (191 aa) | ||||
unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) | ||||
rga-5 | Rho-GAP domain-containing protein. (1341 aa) | ||||
rac-2 | Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa) | ||||
mrck-1 | Serine/threonine-protein kinase mrck-1; Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation. (1592 aa) | ||||
pix-1 | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa) | ||||
osg-1 | Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa) | ||||
cdc-42 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa) | ||||
rhgf-2 | DH domain-containing protein. (1149 aa) | ||||
cav-1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa) | ||||
ppm-2 | Probable protein phosphatase 2C T23F11.1. (356 aa) | ||||
T26C12.3 | RING-type domain-containing protein. (345 aa) | ||||
bath-35 | BTB domain-containing protein. (266 aa) | ||||
rga-1 | Rho-GAP domain-containing protein. (444 aa) | ||||
Y105E8A.25 | DH domain-containing protein. (1619 aa) | ||||
crp-1 | Cdc-42 Related Protein. (187 aa) | ||||
rga-8 | Rho-GAP domain-containing protein. (709 aa) | ||||
max-2 | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa) | ||||
rho-1 | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa) | ||||
rga-2 | Rho GTPase Activating protein. (908 aa) | ||||
Y67D8C.22 | Uncharacterized protein. (225 aa) | ||||
rga-4 | Rho-GAP domain-containing protein. (1135 aa) | ||||
src-1 | Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...] (537 aa) | ||||
nck-1 | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. (395 aa) | ||||
spv-1 | Spermathecal Physiology Variant. (966 aa) | ||||
ZK970.8 | Uncharacterized protein. (143 aa) |