STRINGSTRING
abi-1 abi-1 wsp-1 wsp-1 arx-6 arx-6 C46H11.3 C46H11.3 gex-3 gex-3 hum-1 hum-1 gex-2 gex-2 arx-2 arx-2 toca-2 toca-2 dbn-1 dbn-1 arx-7 arx-7 act-4 act-4 wve-1 wve-1 wip-1 wip-1 act-3 act-3 act-2 act-2 act-1 act-1 arx-5 arx-5 Y55F3AM.5 Y55F3AM.5 Y57G11C.1147 Y57G11C.1147 arx-4 arx-4 arx-1 arx-1 Y73B3B.1 Y73B3B.1 arx-3 arx-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
abi-1SH3 domain-containing protein. (469 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
arx-6Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa)
C46H11.3Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa)
gex-3Membrane-associated protein gex-3; Rac effector required for tissue morphogenesis, cell migrations and egg laying. May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. (1141 aa)
hum-1Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa)
gex-2Cytoplasmic FMR1-interacting protein homolog; Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (1262 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (395 aa)
toca-2Transducer of Cdc42-dependent actin assembly protein 2 homolog; Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as cdc-42 effector. May play a role in egg laying. Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions. Belongs to the FNBP1 family. (610 aa)
dbn-1Drebrin-like protein. (643 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
wve-1WH2 domain-containing protein. (468 aa)
wip-1WH2 domain-containing protein. (362 aa)
act-3Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
act-2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
act-1Actin-1. (376 aa)
arx-5Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
Y55F3AM.5DUF2013 domain-containing protein. (365 aa)
Y57G11C.1147Uncharacterized protein. (74 aa)
arx-4Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
arx-3Actin-related protein 2/3 complex subunit. (375 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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