STRINGSTRING
wdr-5.1 wdr-5.1 set-2 set-2 swd-2.1 swd-2.1 utx-1 utx-1 rbbp-5 rbbp-5 nurf-1 nurf-1 cfp-1 cfp-1 cpar-1 cpar-1 H05L14.2 H05L14.2 wdr-5.2 wdr-5.2 set-16 set-16 pis-1 pis-1 his-73 his-73 ash-2 ash-2 Y75B8A.6 Y75B8A.6 wdr-5.3 wdr-5.3 dpy-30 dpy-30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wdr-5.1WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] (376 aa)
set-2Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa)
swd-2.1WD_REPEATS_REGION domain-containing protein. (322 aa)
utx-1UTX (Ubiquitously transcribed TPR on X) homolog. (1146 aa)
rbbp-5Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. (454 aa)
nurf-1Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa)
cfp-1Zf-CpG_bind_C domain-containing protein. (508 aa)
cpar-1Histone H3-like centromeric protein cpar-1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. (261 aa)
H05L14.2RING-type domain-containing protein. (1624 aa)
wdr-5.2WD repeat-containing protein wdr-5.2; Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'. (395 aa)
set-16Histone-lysine N-methyltransferase. (2475 aa)
pis-1PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. (1076 aa)
his-73Histone domain-containing protein. (46 aa)
ash-2Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa)
Y75B8A.6Uncharacterized protein. (447 aa)
wdr-5.3WD repeat-containing protein wdr-5.3; Not required for methylation of histone H3 'Lys-4'. Belongs to the WD repeat WDR5/wds family. (501 aa)
dpy-30Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (123 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.