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| | che-12 | Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa) |
| | dhc-3 | Dynein Heavy Chain. (3275 aa) |
| | unc-76 | Uncharacterized protein. (388 aa) |
| | mlt-2 | ANK_REP_REGION domain-containing protein. (668 aa) |
| | dyf-11 | Uncharacterized protein. (535 aa) |
| | dyf-3 | Clusterin-associated protein 1 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis ; Belongs to the CLUAP1 family. (404 aa) |
| | pct-1 | Cyclin-dependent kinase 17; Serine/threonine-protein kinase, which, in association with cyy-1, regulates the trafficking of synaptic vesicles in the DA9 motor neuron and probably also in the DD motor neurons and in RIA interneurons. (667 aa) |
| | C09G5.13 | Uncharacterized protein. (249 aa) |
| | mks-5 | Protein fantom; Thought to have an important role in cilia formation and cilia-mediated chemosensation. Involved in the docking of other MKS/MKSR proteins localized to the transition zone of the cilia. Belongs to the RPGRIP1 family. (1322 aa) |
| | egal-1 | Egalitarian protein homolog; Part of a complex with bicd-1 and dlc-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. (574 aa) |
| | kca-1 | Kinesin 1 cargo adaptor alternative variant a. (407 aa) |
| | dyci-1 | WD_REPEATS_REGION domain-containing protein. (643 aa) |
| | klc-2 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. (540 aa) |
| | srg-2 | Serpentine receptor class gamma-2. (327 aa) |
| | ift-74 | IFT (Chlamydomonas IntraFlagellar Transport) homolog. (624 aa) |
| | xbx-4 | DUF3719 domain-containing protein. (111 aa) |
| | dnc-4 | DyNactin Complex component. (413 aa) |
| | che-11 | Uncharacterized protein. (1437 aa) |
| | C27F2.1 | WD Repeat protein. (673 aa) |
| | C27F2.9 | JmjC domain-containing protein. (260 aa) |
| | dyf-13 | Intraflagellar transport protein 56 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. (574 aa) |
| | dnc-2 | Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. (331 aa) |
| | mks-2 | MecKel-Gruber Syndrome (MKS) homolog. (142 aa) |
| | tag-10 | Uncharacterized protein. (473 aa) |
| | C33A12.4 | Uncharacterized protein. (61 aa) |
| | maph-9 | Protein maph-9. (512 aa) |
| | cwp-1 | Coexpressed With Polycystins. (108 aa) |
| | arl-6 | ADP-ribosylation factor-like protein 6; Belongs to the small GTPase superfamily. Arf family. (190 aa) |
| | dli-1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (443 aa) |
| | oac-59 | Acyl_transf_3 domain-containing protein. (698 aa) |
| | C42D8.1 | Uncharacterized protein. (252 aa) |
| | C42D8.9 | Uncharacterized protein. (242 aa) |
| | bicd-1 | Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family. (737 aa) |
| | bbs-9 | Protein pthb1 homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. In ciliated sensory neurons, required for the sens [...] (744 aa) |
| | arp-11 | Actin-Related Proteins; Belongs to the actin family. (384 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | ifta-1 | WD_REPEATS_REGION domain-containing protein. (1246 aa) |
| | ttll-5 | Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons. (730 aa) |
| | C56E6.4 | Doublecortin domain-containing protein. (431 aa) |
| | dylt-2 | DYnein Light chain (Tctex type). (123 aa) |
| | nekl-4 | Serine/threonine-protein kinase D1044.8. (981 aa) |
| | ttll-12 | Tubulin--tyrosine ligase-like protein 12; Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. (662 aa) |
| | cap-1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa) |
| | tctn-1 | DUF1619 domain-containing protein. (470 aa) |
| | ccpp-6 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that catalyzes the removing of polyglutamate side chains that are present on the gamma-carboxyl group of glutamate residues of tubulin in sensory cilia. Probably via the deglutamylation of tubulin, promotes microtubule stability required for axon regrowth after injury. Also regulates microtubule dynamics in uterine muscle cells. Belongs to the peptidase M14 family. (459 aa) |
| | xbx-1 | X-BoX promoter element regulated. (370 aa) |
| | kap-1 | Kinesin-Associated Protein. (696 aa) |
| | tmem-138 | TMEM (Human TransMEMbrane protein) homolog. (176 aa) |
| | F10E9.1 | Uncharacterized protein F10E9.1. (197 aa) |
| | dylt-1 | DYnein Light chain (Tctex type). (106 aa) |
| | F14D7.11 | Uncharacterized protein. (79 aa) |
| | che-3 | Cytoplasmic dynein 2 heavy chain 1; Functions as a motor for intraflagellar retrograde transport in chemosensory neurons. Functions in cilia biogenesis. Belongs to the dynein heavy chain family. (4171 aa) |
| | nekl-3 | Serine/threonine-protein kinase nekl-3; Probable serine/threonine-protein kinase required for the completion of molting; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (302 aa) |
| | arl-3 | ADP-ribosylation factor-like protein 3; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (184 aa) |
| | klp-11 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (782 aa) |
| | rbg-1 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (915 aa) |
| | bbs-2 | Bardet-Biedl syndrome 2 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. (714 aa) |
| | daf-10 | Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa. (1192 aa) |
| | ttll-9 | Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth. (417 aa) |
| | F25D7.5 | EGF-like domain-containing protein. (1216 aa) |
| | F26C11.3 | Uncharacterized protein F26C11.3. (1312 aa) |
| | F28A12.3 | Uncharacterized protein. (160 aa) |
| | F31F7.2 | VWFA domain-containing protein. (689 aa) |
| | ift-81 | IFT81_CH domain-containing protein. (638 aa) |
| | tba-6 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa) |
| | daf-19 | RFX-like transcription factor daf-19; May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression; Belongs to the RFX family. (805 aa) |
| | che-10 | Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Required for cilia integrity and function in sensory neurons. Maintains cilia integrity, partly by modulating the assembly and transport of intraflagellar proteins along the ciliary axoneme. Required for normal mating behavior and normal responses to environmental and chemical stimuli. (1955 aa) |
| | mks-3 | MecKel-Gruber Syndrome (MKS) homolog. (897 aa) |
| | tbc-11 | Rab-GAP TBC domain-containing protein. (934 aa) |
| | che-2 | CHE-2 protein. (760 aa) |
| | dyla-1 | DYnein Light chain, Axonemal p28 type. (271 aa) |
| | F42G8.19 | Rhodanese domain-containing protein. (182 aa) |
| | dyf-6 | Intraflagellar transport protein 46 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for normal morphology and function of ciliated amphid sensory neurons. (471 aa) |
| | nud-1 | CS domain-containing protein. (320 aa) |
| | jbts-14 | Transmembrane protein 237 homolog; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family. (399 aa) |
| | F53A9.7 | Uncharacterized protein. (85 aa) |
| | dyf-1 | Tetratricopeptide repeat protein 30 homolog; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors. Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motili [...] (656 aa) |
| | F55A4.3 | Uncharacterized protein. (70 aa) |
| | jip-1 | PID domain-containing protein. (998 aa) |
| | ccpp-1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. (1015 aa) |
| | bbs-4 | Bardet-Biedl syndrome 4 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). May be required for microtubule anchoring at the centrosome but not for microtubule nucleation (By similarity). May be required for the dynein- m [...] (462 aa) |
| | F58E6.11 | Uncharacterized protein. (188 aa) |
| | F59A6.3 | Sushi domain-containing protein. (786 aa) |
| | rab-6.1 | Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa) |
| | che-13 | Intraflagellar transport protein che-13; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for the formation of chemosensory cilia that detect chemosensory cues ; Belongs to the IFT57 family. (412 aa) |
| | F59G1.4 | F59G1.4. (580 aa) |
| | dyf-18 | Protein kinase domain-containing protein. (323 aa) |
| | ttll-11 | Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] (707 aa) |
| | mksr-1 | MecKel Syndrome 1 (MKS1)-Related. (229 aa) |
| | K04F10.2 | Protein KIAA0556 homolog; May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity. (568 aa) |
| | K07C11.10 | Uncharacterized protein. (125 aa) |
| | ttll-15 | Probable tubulin polyglutamylase ttll-15; Probable polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. (513 aa) |
| | mks-6 | C2 domain-containing protein. (1202 aa) |
| | rpi-2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (341 aa) |
| | unc-14 | RUN domain-containing protein. (665 aa) |
| | klp-7 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (747 aa) |
| | vab-8 | Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa) |
| | M01F1.9 | Uncharacterized protein. (366 aa) |
| | cap-2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa) |
| | unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa) |
| | dlc-2 | Probable dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of a dynein complex; Belongs to the dynein light chain family. (90 aa) |
| | nphp-1 | Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium. (682 aa) |
| | klc-1 | TPR_REGION domain-containing protein. (536 aa) |
| | bbs-5 | Bardet-Biedl syndrome 5 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). Required, redundantly with bbs-4, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins al [...] (361 aa) |
| | unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) |
| | R05H5.5 | ARV1 homolog. (236 aa) |
| | R06F6.8 | Guanine nucleotide exchange factor subunit R06F6.8; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi; Belongs to the RIC1 family. (1470 aa) |
| | nud-2 | Protein nud-2; Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord ; Belongs to the nudE family. (293 aa) |
| | nphp-4 | NePHronoPhthisis (Human kidney disease) homolog. (1305 aa) |
| | klp-6 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa) |
| | mks-1 | MecKel-Gruber Syndrome (MKS) homolog. (485 aa) |
| | osm-6 | Osm-6 protein. (472 aa) |
| | lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa) |
| | dylt-3 | DYnein Light chain (Tctex type). (148 aa) |
| | unc-69 | Uncharacterized protein. (176 aa) |
| | T09B9.4 | Uncharacterized protein T09B9.4. (528 aa) |
| | coa-4 | Cytochrome Oxidase Assembly subunits. (293 aa) |
| | dhc-1 | Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells. May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron. This function may involve the regulation of dynein by pct-1 and/or cdk-5. Involved in the formation of synapses in the dorsal regi [...] (4568 aa) |
| | rbg-2 | Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1307 aa) |
| | tmem-218 | TMEM (Human TransMEMbrane protein) homolog. (126 aa) |
| | cdka-1 | Cyclin-dependent kinase 5 activator 1; Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic [...] (366 aa) |
| | dyrb-1 | Dynein light chain roadblock; Belongs to the GAMAD family. (95 aa) |
| | bbs-8 | Tetratricopeptide repeat protein 8; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in guanylyl cyclase loca [...] (506 aa) |
| | rab-6.2 | Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa) |
| | dlc-1 | Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...] (89 aa) |
| | tmem-231 | TMEM (Human TransMEMbrane protein) homolog. (304 aa) |
| | osm-1 | Intraflagellar transport protein osm-1; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for the maintenance and formation of chemosensory cilia that detect chemosensory cues. (1737 aa) |
| | cdk-5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa) |
| | ifta-2 | Intraflagellar transport associated protein 2; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Regulates specific signaling activities in the cilia, such as the daf-2/insulin receptor-like transduction pathway. (252 aa) |
| | cil-7 | CILiary localization. (548 aa) |
| | dhc-4 | DHC_N2 domain-containing protein. (2727 aa) |
| | W07G1.1 | Doublecortin domain-containing protein. (291 aa) |
| | rpi-1 | Protein rpi-1. (450 aa) |
| | dnc-3 | DyNactin Complex component. (171 aa) |
| | bbs-1 | Bardet-Biedl syndrome 1 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. (576 aa) |
| | dlc-6 | Dynein Light Chain. (129 aa) |
| | cfap-36 | Cilia- and flagella-associated protein 36. (685 aa) |
| | dlc-3 | Dynein light chain. (129 aa) |
| | dlc-4 | Dynein light chain. (129 aa) |
| | trf-2 | MATH domain-containing protein. (335 aa) |
| | ift-20 | Intraflagellar transport protein 20 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. (129 aa) |
| | sql-1 | Suppressor of gpa-3QL dye-filling defect. (1328 aa) |
| | rab-28 | Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa) |
| | arl-13 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. Required for normal sensory cilium function. May act by maintaining the association between IFT subcomplexes A and B; Belongs to the small GTPase superfamily. Arf family. (370 aa) |
| | mksr-2 | MecKel Syndrome 1 (MKS1)-Related. (175 aa) |
| | famh-161 | Protein fam-161. (814 aa) |
| | dyf-17 | Uncharacterized protein. (366 aa) |
| | mlt-3 | ANK_REP_REGION domain-containing protein. (392 aa) |
| | nekl-1 | Protein kinase domain-containing protein. (983 aa) |
| | osm-5 | OSM-5. (820 aa) |
| | cdkl-1 | Cyclin-dependent kinase-like 1; Modulates cilium assembly. (484 aa) |
| | ccep-290 | CEntrosomal Protein. (1736 aa) |
| | Y50C1A.2 | Uncharacterized protein. (406 aa) |
| | klp-20 | Kinesin-like protein klp-20; Component of the kinesin II motor complex (composed of kap-1 and the heterodimeric motor proteins klp-11 and klp-20) which is required for intraflagellar transport (IFT). Heterodimerizes with klp-11 to form a 'processive' molecular motor upon IFT cargo binding, which, within the kinesin II motor complex, binds to and moves along microtubules in a unidirectional manner (without dissociation of the heterodimer), and in turn, is responsible for the IFT of cargo. Specifically, the kinesin II motor complex, together with the kinesin motor protein osm-3 moves alo [...] (646 aa) |
| | arp-1 | Actin-Related Proteins; Belongs to the actin family. (374 aa) |
| | Y53G8AM.4 | RING-type domain-containing protein. (309 aa) |
| | dnc-6 | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. (180 aa) |
| | tbc-20 | Rab-GAP TBC domain-containing protein. (411 aa) |
| | arl-8 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa) |
| | egas-1 | EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (938 aa) |
| | Y70G10A.2 | EGF-like domain-containing protein. (1489 aa) |
| | dnc-5 | DyNactin Complex component. (184 aa) |
| | Y71F9B.6 | Cyclin N-terminal domain-containing protein. (534 aa) |
| | dlc-5 | Dynein Light Chain. (186 aa) |
| | pkd-2 | Polycystin-2; Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior. (716 aa) |
| | osm-12 | Bardet-Biedl syndrome 7 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in [...] (721 aa) |
| | rab-18 | Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells. (203 aa) |
| | mlt-4 | ANK_REP_REGION domain-containing protein. (624 aa) |
| | cdk-11.2 | Cyclin-dependent kinase 11.2; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility. (668 aa) |
| | nekl-2 | Serine/threonine-protein kinase nekl-2; Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium. (357 aa) |
| | unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) |
| | ttll-4 | Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. (601 aa) |
| | ift-139 | Tetratricopeptide repeat protein 21 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility. Functions in cilia biogenesis. Belongs to the TTC21 family. (1324 aa) |
| | cyy-1 | Cyclin-Y; In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons. Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures. May activate cdk-5. Belongs to the cyclin family. (357 aa) |
| | tmem-17 | TMEM (Human TransMEMbrane protein) homolog. (145 aa) |
| | dyf-2 | WD repeat-containing protein dyf-2; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues. (1383 aa) |
| | dnc-1 | CAP-Gly domain-containing protein. (1351 aa) |
| | lov-1 | Location of vulva defective 1; Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2. (3284 aa) |
