STRINGSTRING
che-12 che-12 C27F2.1 C27F2.1 maph-9 maph-9 C42D8.1 C42D8.1 C42D8.9 C42D8.9 C56E6.4 C56E6.4 che-10 che-10 F59G1.4 F59G1.4 K04F10.2 K04F10.2 W07G1.1 W07G1.1 rpi-1 rpi-1 rab-28 rab-28 famh-161 famh-161
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
che-12Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa)
C27F2.1WD Repeat protein. (673 aa)
maph-9Protein maph-9. (512 aa)
C42D8.1Uncharacterized protein. (252 aa)
C42D8.9Uncharacterized protein. (242 aa)
C56E6.4Doublecortin domain-containing protein. (431 aa)
che-10Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Required for cilia integrity and function in sensory neurons. Maintains cilia integrity, partly by modulating the assembly and transport of intraflagellar proteins along the ciliary axoneme. Required for normal mating behavior and normal responses to environmental and chemical stimuli. (1955 aa)
F59G1.4F59G1.4. (580 aa)
K04F10.2Protein KIAA0556 homolog; May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity. (568 aa)
W07G1.1Doublecortin domain-containing protein. (291 aa)
rpi-1Protein rpi-1. (450 aa)
rab-28Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa)
famh-161Protein fam-161. (814 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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