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| | memb-1 | Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa) |
| | ykt-6 | YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family. (201 aa) |
| | vamp-8 | V-SNARE coiled-coil homology domain-containing protein. (116 aa) |
| | C06B8.2 | Uncharacterized protein. (433 aa) |
| | snt-6 | C2 domain-containing protein. (373 aa) |
| | lin-10 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. (982 aa) |
| | syx-6 | Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (122 aa) |
| | C16D9.5 | Uncharacterized protein. (392 aa) |
| | rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) |
| | snb-5 | Synaptobrevin-like protein 5. (102 aa) |
| | rskn-2 | Putative ribosomal protein S6 kinase alpha-2; Serine/threonine kinase that may play a role in mediating the mitogen- and stress-induced effects on transcription. May repress transcription via phosphorylation of 'Ser-1' of histone H2A. May phosphorylate histone H3 (By similarity). (773 aa) |
| | snap-1 | SNAP (Soluble NSF Attachment Protein) homolog. (295 aa) |
| | mctp-1 | Multiple C2 and Transmembrane region Protein family homolog. (822 aa) |
| | pkc-2 | Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (936 aa) |
| | gos-28 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation. (234 aa) |
| | lin-2 | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. (961 aa) |
| | mltn-9 | MLt-TeN (Mlt-10) related. (749 aa) |
| | mltn-10 | MLt-TeN (Mlt-10) related. (607 aa) |
| | czw-1 | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC8 [...] (778 aa) |
| | smgl-1 | Uncharacterized protein. (1615 aa) |
| | snb-2 | V-SNARE coiled-coil homology domain-containing protein. (114 aa) |
| | unc-18 | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. (591 aa) |
| | F28G4.3 | Uncharacterized protein. (358 aa) |
| | snt-1 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa) |
| | syx-3 | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa) |
| | syx-7 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (248 aa) |
| | sec-20 | Yeast SEC homolog; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (234 aa) |
| | elks-1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa) |
| | sph-1 | MARVEL domain-containing protein. (227 aa) |
| | snt-2 | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa) |
| | sly-1 | SLY1 homolog; Belongs to the STXBP/unc-18/SEC1 family. (675 aa) |
| | fer-1 | Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis. (2034 aa) |
| | F46F5.10 | Uncharacterized protein. (369 aa) |
| | syx-2 | Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (299 aa) |
| | syx-5 | Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa) |
| | sec-22 | Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) |
| | nsf-1 | Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family. (824 aa) |
| | snap-29 | Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family. (277 aa) |
| | tom-1 | LLGL domain-containing protein. (1255 aa) |
| | memb-2 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa) |
| | syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) |
| | T07A9.10 | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (562 aa) |
| | unc-10 | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] (1563 aa) |
| | snt-7 | C2 domain-containing protein. (416 aa) |
| | syx-18 | t-SNARE coiled-coil homology domain-containing protein. (415 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | esyt-2 | C2 domain-containing protein. (713 aa) |
| | snb-6 | V-SNARE coiled-coil homology domain-containing protein. (102 aa) |
| | aex-4 | t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family. (234 aa) |
| | syx-17 | t-SNARE coiled-coil homology domain-containing protein. (250 aa) |
| | cat-1 | MFS domain-containing protein. (553 aa) |
| | mltn-4 | MLt-TeN (Mlt-10) related. (733 aa) |
| | use-1 | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER; Belongs to the USE1 family. (254 aa) |
| | sri-18 | Serpentine Receptor, class I. (346 aa) |
| | ric-4 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa) |
| | snn-1 | ATP-grasp domain-containing protein. (474 aa) |
| | rimb-1 | RIM Binding protein. (1276 aa) |
| | mltn-8 | MLt-TeN (Mlt-10) related. (799 aa) |
| | lin-7 | Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (209 aa) |
| | Y54G11A.17 | Uncharacterized protein. (124 aa) |
| | vti-1 | t-SNARE coiled-coil homology domain-containing protein. (224 aa) |
| | Y59A8B.25 | Uncharacterized protein. (145 aa) |
| | Y59A8B.8 | Uncharacterized protein. (299 aa) |
| | nbet-1 | t-SNARE coiled-coil homology domain-containing protein. (107 aa) |
| | cpx-1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. (143 aa) |
| | snt-3 | SyNapTotagmin. (284 aa) |
| | syx-16 | t-SNARE coiled-coil homology domain-containing protein. (329 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | snb-7 | V-SNARE coiled-coil homology domain-containing protein. (102 aa) |
