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casy-1 | CAlSYntenin/Alcadein homolog. (984 aa) | ||||
unc-5 | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa) | ||||
lat-2 | Latrophilin-like protein LAT-2; May have a role in pharyngeal pumping during feeding. (1338 aa) | ||||
lat-1 | Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (1014 aa) | ||||
lron-3 | LRRCT domain-containing protein. (369 aa) | ||||
ptp-3 | Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors. (2248 aa) | ||||
catp-8 | Probable manganese-transporting ATPase catp-8; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. (1178 aa) | ||||
C14B4.2 | Uncharacterized protein. (1776 aa) | ||||
zig-3 | Zwei Ig domain protein zig-3; Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement. (251 aa) | ||||
sax-7 | Fibronectin type-III domain-containing protein. (1331 aa) | ||||
syg-2 | Synaptogenesis protein syg-2; Cell adhesion protein. Determines synapse formation. Required for correct localization of syg-1 at synaptic sites. (1230 aa) | ||||
unc-86 | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] (357 aa) | ||||
rig-6 | Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior. (1196 aa) | ||||
C34F6.10 | Uncharacterized protein. (1465 aa) | ||||
rig-5 | Ig-like domain-containing protein. (482 aa) | ||||
madd-2 | Uncharacterized protein. (765 aa) | ||||
lron-4 | ELRR (Extracellular Leucine-Rich Repeat) ONly. (633 aa) | ||||
apl-1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] (686 aa) | ||||
nab-1 | NeurABin. (721 aa) | ||||
efn-2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (218 aa) | ||||
rig-3 | Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling. (487 aa) | ||||
smp-2 | Sema domain-containing protein; Belongs to the semaphorin family. (649 aa) | ||||
mec-3 | Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa) | ||||
mig-21 | Abnormal cell migration protein 21; Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left- side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration. (313 aa) | ||||
ncam-1 | NCAM (Neural cell adhesion molecule) homolog. (955 aa) | ||||
F07A5.4 | Olfactomedin-like domain-containing protein. (363 aa) | ||||
cdh-5 | CaDHerin family. (1449 aa) | ||||
unc-115 | Uncharacterized protein. (639 aa) | ||||
mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) | ||||
kpc-1 | Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...] (692 aa) | ||||
efn-3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (211 aa) | ||||
sad-1 | Serine/threonine kinase SAD-1; Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology. (914 aa) | ||||
fmi-1 | FlaMIngo (Cadherin plus 7TM domain) homolog. (2596 aa) | ||||
cdh-8 | CaDHerin family. (1684 aa) | ||||
cdh-4 | Cadherin-4; Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord. (4328 aa) | ||||
lhfp-4 | Lipoma Hmgic (HMGIC) Fusion Partner-like homolog. (229 aa) | ||||
egl-44 | Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. (493 aa) | ||||
mth-1 | GPS domain-containing protein. (1788 aa) | ||||
eva-1 | Protein eva-1; Acts as a receptor for slt-1. Required for the guidance of the AVM pioneer axon to the ventral nerve cord. Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline. Belongs to the EVA1 family. (470 aa) | ||||
syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) | ||||
nas-39 | Zinc metalloproteinase nas-39; Metalloprotease. (951 aa) | ||||
igcm-1 | ImmunoGlobulin-like Cell adhesion Molecule family. (1073 aa) | ||||
slt-1 | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. (1410 aa) | ||||
unc-6 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa) | ||||
wrk-1 | Wrapper/Rega-1/Klingon homolog. (452 aa) | ||||
zig-2 | Zwei Ig domain protein zig-2; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (238 aa) | ||||
pag-3 | Zinc finger protein PAG-3. (336 aa) | ||||
F49H12.4 | Uncharacterized protein. (125 aa) | ||||
efn-4 | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. (348 aa) | ||||
gfi-1 | GEI-4 (Four) Interacting protein. (2153 aa) | ||||
cdh-9 | CaDHerin family. (623 aa) | ||||
kcc-3 | Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC. (1081 aa) | ||||
syg-1 | Synaptogenesis protein syg-1; Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F- actin assembly at the synaptic region and for axon branch formation. (730 aa) | ||||
plx-2 | Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...] (1766 aa) | ||||
lect-2 | Peptidase_M23 domain-containing protein. (335 aa) | ||||
egg-6 | Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance. (961 aa) | ||||
rig-1 | NeuRonal IGCAM. (1147 aa) | ||||
zig-1 | Zwei Ig domain protein zig-1; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. (265 aa) | ||||
egl-46 | C2H2-type domain-containing protein. (286 aa) | ||||
vab-1 | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] (1122 aa) | ||||
hpo-30 | Uncharacterized protein. (279 aa) | ||||
dpr-1 | Dauer Pheromone Responsive. (356 aa) | ||||
cdh-1 | CaDHerin family. (2779 aa) | ||||
ten-1 | Teneurin-1; Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons. (2837 aa) | ||||
igcm-2 | ImmunoGlobulin-like Cell adhesion Molecule family. (718 aa) | ||||
dma-1 | LRRCT domain-containing protein. (603 aa) | ||||
unc-40 | Unc-40 protein. (1415 aa) | ||||
oig-8 | Ig-like domain-containing protein. (285 aa) | ||||
zig-10 | 2 (Zwei) IG domain protein. (322 aa) | ||||
mnr-1 | MeNoRin (Dendritic branching protein). (530 aa) | ||||
ztf-6 | Zinc finger putative Transcription Factor family. (480 aa) | ||||
ttn-1 | Titin homolog; Serine/threonine-protein kinase. Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity). (15188 aa) | ||||
zig-9 | Ig-like domain-containing protein. (283 aa) | ||||
fmil-1 | GPS domain-containing protein. (1043 aa) | ||||
vab-2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (279 aa) | ||||
zig-8 | Zwei Ig domain protein zig-8; Together with zig-5, required postembryonically to maintain the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP and HSN neurons by preventing their displacement that could occur during body growth and movement. May act by reducing L1CAM-like protein sax-7 (long isoform) adhesion. (268 aa) | ||||
rig-4 | Protein sidekick homolog; Cell adhesion protein; Belongs to the sidekick family. (2325 aa) | ||||
unc-34 | WH1 domain-containing protein. (468 aa) | ||||
smp-1 | Semaphorin-1A; May function in growth cone guidance; Belongs to the semaphorin family. (712 aa) | ||||
lad-2 | Immunoglobulin domain-containing protein Y54G2A.25. (1187 aa) | ||||
plx-1 | Sema domain-containing protein. (1956 aa) | ||||
oig-5 | Ig-like domain-containing protein. (164 aa) | ||||
bam-2 | Neurexin-related protein bam-2; Maintains the normal guidance and termination of axonal branches of VC motorneurons. By associating with cell adhesion protein casy-1, mediates axonal interactions to establish synaptic connections between the male-specific sensory neuron HOA and the AVG interneuron. Plays a role in regulating male mating behavior. (1007 aa) | ||||
mab-20 | Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (658 aa) | ||||
Y73E7A.3 | Uncharacterized protein. (482 aa) | ||||
lron-12 | ELRR (Extracellular Leucine-Rich Repeat) ONly. (401 aa) | ||||
sax-3 | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. (1273 aa) | ||||
seb-2 | G-protein coupled receptor seb-2; Not known. Putative receptor. (522 aa) |