STRINGSTRING
lig-4 lig-4 com-1 com-1 wrn-1 wrn-1 dna-2 dna-2 exo-1 exo-1 cku-80 cku-80 rad-50 rad-50 rad-54 rad-54 Y116A8C.13 Y116A8C.13 pif-1 pif-1 rad-51 rad-51 cku-70 cku-70 mre-11 mre-11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lig-4LIGase. (741 aa)
com-1Completion Of Meiotic recombination (Budding yeast Com) related. (525 aa)
wrn-1Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity). (1056 aa)
dna-2Yeast DNA helicase/endonuclease family. (1069 aa)
exo-1EXOnuclease. (639 aa)
cku-80ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (713 aa)
rad-50DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity. (1312 aa)
rad-54Uncharacterized protein. (818 aa)
Y116A8C.13Uncharacterized protein. (833 aa)
pif-1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (677 aa)
rad-51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. (395 aa)
cku-70Ku domain-containing protein. (679 aa)
mre-11Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family. (728 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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