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gpa-14 gpa-14 rgs-1 rgs-1 gar-1 gar-1 gpa-11 gpa-11 eat-16 eat-16 dop-6 dop-6 rgs-3 rgs-3 C30A5.10 C30A5.10 rgs-6 rgs-6 gnrr-4 gnrr-4 npr-18 npr-18 gpa-10 gpa-10 nmur-3 nmur-3 gpc-2 gpc-2 F10D7.1 F10D7.1 gpb-1 gpb-1 rhgf-1 rhgf-1 octr-1 octr-1 F16C3.1 F16C3.1 ser-5 ser-5 rgs-2 rgs-2 gpa-13 gpa-13 gpa-12 gpa-12 gtr-1 gtr-1 egl-10 egl-10 F36D4.4 F36D4.4 gpa-2 gpa-2 npr-27 npr-27 rgs-11 rgs-11 rgs-10 rgs-10 gar-2 gar-2 gpb-2 gpb-2 gpa-5 gpa-5 gpa-8 gpa-8 gpa-9 gpa-9 K01A12.3 K01A12.3 gpc-1 gpc-1 nmur-2 nmur-2 gpa-15 gpa-15 npr-26 npr-26 npr-25 npr-25 gpa-4 gpa-4 ntr-1 ntr-1 nmt-1 nmt-1 ador-1 ador-1 npr-21 npr-21 npr-15 npr-15 gpa-18 gpa-18 npr-14 npr-14 rgs-4 rgs-4 gar-3 gar-3 gbb-1 gbb-1 mgl-3 mgl-3 gpa-17 gpa-17 gro-1 gro-1 mgl-1 mgl-1 rgs-9 rgs-9 gbb-2 gbb-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpa-14Guanine nucleotide-binding protein alpha-14 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (408 aa)
rgs-1Regulator of G-protein signaling rgs-1; Inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, protein acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. (247 aa)
gar-1Probable muscarinic acetylcholine receptor gar-1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (713 aa)
gpa-11Guanine nucleotide-binding protein alpha-11 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Mediates the transduction of food and serotonin signals, which modulates the avoidance response to the odorant octanol. Has a role in lifespan to promote longevity. (529 aa)
eat-16Uncharacterized protein. (473 aa)
dop-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (682 aa)
rgs-3Regulator of G-protein signaling rgs-3; Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons. (363 aa)
C30A5.10Uncharacterized protein C30A5.10. (988 aa)
rgs-6Regulator of G-protein signaling rgs-6. (734 aa)
gnrr-4G_PROTEIN_RECEP_F1_2 domain-containing protein. (557 aa)
npr-18Neuropeptide receptor 18; Probable receptor for neuropeptide ligand nlp-9 that plays a role in octopamine signaling and specifically, the octapamine inhibition of aversion responses in olfactory sensory neurons. In AWB olfactory sensory neurons, required for the detection of preferred food sources. Belongs to the G-protein coupled receptor 1 family. (507 aa)
gpa-10Guanine nucleotide-binding protein alpha-10 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa)
nmur-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
gpc-2G protein gamma domain-containing protein. (62 aa)
F10D7.1G_PROTEIN_RECEP_F1_2 domain-containing protein. (435 aa)
gpb-1Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)
rhgf-1RHo Guanine nucleotide exchange Factor. (1340 aa)
octr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (408 aa)
F16C3.1G_PROTEIN_RECEP_F1_2 domain-containing protein. (399 aa)
ser-5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (454 aa)
rgs-2Regulator of G-protein signaling rgs-2; Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons. (181 aa)
gpa-13Guanine nucleotide-binding protein alpha-13 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (402 aa)
gpa-12Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. (355 aa)
gtr-1GPCR Thermal Receptor. (329 aa)
egl-10Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. (639 aa)
F36D4.4G_PROTEIN_RECEP_F1_2 domain-containing protein. (523 aa)
gpa-2Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. Belongs to the G-alpha family. G(q) subfamily. (356 aa)
npr-27G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
rgs-11Regulator of G-protein signaling rgs-11. (274 aa)
rgs-10Regulator of G-protein signaling rgs-10; Shown to have a role in viability and embryogenesis. (270 aa)
gar-2Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] (667 aa)
gpb-2Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa)
gpa-5Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (385 aa)
gpa-8Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (364 aa)
gpa-9Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (96 aa)
K01A12.3Probable G-protein coupled receptor K01A12.3. (496 aa)
gpc-1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
nmur-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
gpa-15Guanine nucleotide-binding protein alpha-15 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa)
npr-26G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (461 aa)
npr-25G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
gpa-4Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (359 aa)
ntr-1Nematocin receptor 1; Receptor for nematocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The activity of this receptor may be modulated by ntr-2, leading to reduced intracellular cAMP production. Plays a role in gustatory associative learning. Also plays a role in male mating behavior ; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (379 aa)
nmt-1Probable glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. (452 aa)
ador-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (362 aa)
npr-21G_PROTEIN_RECEP_F1_2 domain-containing protein. (362 aa)
npr-15Neuropeptide receptor 15; Probable receptor for neuropeptide ligand nlp-8 that plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons. Belongs to the G-protein coupled receptor 1 family. (345 aa)
gpa-18G Protein, Alpha subunit. (320 aa)
npr-14G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (342 aa)
rgs-4RGS domain-containing protein. (216 aa)
gar-3Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. (611 aa)
gbb-1Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (899 aa)
mgl-3G_PROTEIN_RECEP_F3_4 domain-containing protein. (1008 aa)
gpa-17G Protein, Alpha subunit. (406 aa)
gro-1tRNA isopentenyl transferase; Belongs to the IPP transferase family. (430 aa)
mgl-1Probable metabotropic glutamate receptor mgl-1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity). (952 aa)
rgs-9Regulator of G-protein signaling rgs-9. (235 aa)
gbb-2Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (842 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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