STRINGSTRING
gcy-1 gcy-1 daf-11 daf-11 gcy-32 gcy-32 acy-2 acy-2 glb-5 glb-5 pdl-1 pdl-1 pde-5 pde-5 odr-3 odr-3 acy-3 acy-3 gcy-36 gcy-36 gcy-8 gcy-8 gcy-37 gcy-37 gpa-3 gpa-3 gcy-12 gcy-12 cng-1 cng-1 acy-1 acy-1 gcy-20 gcy-20 tax-2 tax-2 cng-3 cng-3 gcy-33 gcy-33 gcy-34 gcy-34 odr-1 odr-1 gsa-1 gsa-1 kin-2 kin-2 pde-2 pde-2 pde-4 pde-4 gcy-28 gcy-28 acy-4 acy-4 gcy-22 gcy-22 gcy-35 gcy-35 gcy-31 gcy-31 gcy-23 gcy-23 gcy-17 gcy-17 ttx-1 ttx-1 cng-2 cng-2 pde-6 pde-6 tax-4 tax-4 gcy-18 gcy-18 kin-1 kin-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gcy-1Receptor-type guanylate cyclase gcy-1; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron. (1137 aa)
daf-11Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] (1077 aa)
gcy-32Soluble guanylate cyclase gcy-32; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases. (684 aa)
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
glb-5GLOBIN domain-containing protein; Belongs to the globin family. (397 aa)
pdl-1Phosphodiesterase delta-like protein. (159 aa)
pde-5Probable 3',5'-cyclic phosphodiesterase pde-5; Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels. (728 aa)
odr-3Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...] (356 aa)
acy-3Adenylyl CYclase. (1243 aa)
gcy-36Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...] (675 aa)
gcy-8Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. (1152 aa)
gcy-37Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (708 aa)
gpa-3Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...] (353 aa)
gcy-12Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size. (1679 aa)
cng-1Cyclic nucleotide-binding domain-containing protein. (661 aa)
acy-1Adenylyl CYclase. (1253 aa)
gcy-20Receptor-type guanylate cyclase gcy-20; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1108 aa)
tax-2Cyclic nucleotide-binding domain-containing protein. (800 aa)
cng-3Cyclic nucleotide-binding domain-containing protein. (626 aa)
gcy-33Soluble guanylate cyclase gcy-33; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (947 aa)
gcy-34Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (686 aa)
odr-1Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...] (1067 aa)
gsa-1G protein, Subunit Alpha. (378 aa)
kin-2cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. (376 aa)
pde-2Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. (831 aa)
pde-4Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. (674 aa)
gcy-28Receptor-type guanylate cyclase gcy-28; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps. [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons. (1276 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
gcy-22Receptor-type guanylate cyclase gcy-22; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations. (1058 aa)
gcy-35Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa)
gcy-31Soluble guanylate cyclase gcy-31; Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis. (702 aa)
gcy-23Receptor-type guanylate cyclase gcy-23; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1073 aa)
gcy-17Receptor-type guanylate cyclase gcy-17; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1088 aa)
ttx-1Homeobox domain-containing protein. (391 aa)
cng-2Cyclic nucleotide-binding domain-containing protein. (819 aa)
pde-6Probable 3',5'-cyclic phosphodiesterase pde-6; Belongs to the cyclic nucleotide phosphodiesterase family. (760 aa)
tax-4Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa)
gcy-18Receptor-type guanylate cyclase gcy-18; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1113 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.