STRINGSTRING
nlp-38 nlp-38 nlp-1 nlp-1 snet-1 snet-1 flp-5 flp-5 flp-12 flp-12 npr-17 npr-17 C07A12.2 C07A12.2 npr-3 npr-3 pdfr-1 pdfr-1 xbx-9 xbx-9 npr-4 npr-4 seb-3 seb-3 flp-4 flp-4 flp-24 flp-24 npr-11 npr-11 flp-21 flp-21 frpr-3 frpr-3 flp-9 flp-9 npr-1 npr-1 egl-6 egl-6 srh-18 srh-18 flp-17 flp-17 nlp-15 nlp-15 nlp-14 nlp-14 nlp-8 nlp-8 flp-20 flp-20 nlp-13 nlp-13 nlp-9 nlp-9 nlp-59 nlp-59 flp-6 flp-6 ntr-2 ntr-2 flp-16 flp-16 F17C11.2 F17C11.2 pgal-1 pgal-1 flp-23 flp-23 flp-1 flp-1 flp-8 flp-8 nlp-18 nlp-18 flp-13 flp-13 nlp-24 nlp-24 nlp-5 nlp-5 nlp-10 nlp-10 ntc-1 ntc-1 flp-22 flp-22 sprr-2 sprr-2 nlp-20 nlp-20 nlp-37 nlp-37 nlp-3 nlp-3 flp-7 flp-7 sto-3 sto-3 F58H1.7 F58H1.7 crf-1 crf-1 K02F2.5 K02F2.5 flp-11 flp-11 flp-25 flp-25 nlp-19 nlp-19 nlp-12 nlp-12 M04D8.7 M04D8.7 flp-19 flp-19 flp-32 flp-32 flp-34 flp-34 npr-24 npr-24 nlp-67 nlp-67 flp-26 flp-26 nlp-80 nlp-80 flp-10 flp-10 nlp-58 nlp-58 flp-33 flp-33 pdf-1 pdf-1 nlp-33 nlp-33 frpr-18 frpr-18 ckr-1 ckr-1 nlp-6 nlp-6 nlp-22 nlp-22 nlp-2 nlp-2 T27C4.1 T27C4.1 flp-3 flp-3 flp-2 flp-2 flp-28 flp-28 flp-14 flp-14 ins-16 ins-16 ckr-2 ckr-2 nlp-17 nlp-17 flp-18 flp-18 npr-34 npr-34 ndnf-1 ndnf-1 npr-5 npr-5 npr-22 npr-22 nlp-81 nlp-81 pghm-1 pghm-1 nlp-71 nlp-71 npr-9 npr-9 flp-15 flp-15
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nlp-38Neuropeptide-like protein 38; Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. [MIP-1-2]: Neuropeptide ligand for the G-protein coupled receptor sprr-2. (120 aa)
nlp-1Neuropeptide-like protein 1; In AWC olfactory sensory neurons, required for the detection of preferred food sources. (176 aa)
snet-1Protein snet-1; Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity. (101 aa)
flp-5FMRFamide-like neuropeptides 5; FMRFamides and FMRFamide-like peptides are neuropeptides. GAKFIRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (92 aa)
flp-12FMRFamide-like peptide 12. (85 aa)
npr-17Probable G-protein coupled receptor C06G4.5; Putative receptor; Belongs to the G-protein coupled receptor 1 family. (436 aa)
C07A12.2Uncharacterized protein. (67 aa)
npr-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
pdfr-1Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity. (546 aa)
xbx-9X-BoX promoter element regulated. (441 aa)
npr-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (490 aa)
seb-3Secretin receptor-like protein SEB-3; Belongs to the G-protein coupled receptor 2 family. (454 aa)
flp-4FMRFamide-like peptide 4. (93 aa)
flp-24FMRFamide-like neuropeptides 24; FMRFamides and FMRFamide-like peptides are neuropeptides. (69 aa)
npr-11Putative neuropeptide Y receptor 11; Could be a receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (402 aa)
flp-21FMRF-Like Peptide. (66 aa)
frpr-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
flp-9FMRFamide-like neuropeptides 9; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family. (102 aa)
npr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa)
egl-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (395 aa)
srh-18Serpentine Receptor, class H. (329 aa)
flp-17FMRF-Like Peptide. (130 aa)
nlp-15Neuropeptide-Like Protein. (143 aa)
nlp-14Neuropeptide-Like Protein. (224 aa)
nlp-8Neuropeptide-Like Protein. (172 aa)
flp-20FMRF-Like Peptide. (95 aa)
nlp-13Neuropeptide-Like Protein. (137 aa)
nlp-9Neuropeptide-Like Protein. (129 aa)
nlp-59Neuropeptide-Like Protein. (89 aa)
flp-6FMRFamide-like neuropeptides 6; FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (170 aa)
ntr-2Nematocin receptor 2; Not directly activated by nematocin. May modulate activity of the nematocin receptor ntr- 1, leading to reduced intracellular cAMP production. Plays a role in male mating behavior. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (398 aa)
flp-16FMRFamide-like neuropeptides 16; FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system. (92 aa)
F17C11.2Uncharacterized protein. (91 aa)
pgal-1Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1; Probable lyase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity). (350 aa)
flp-23VVGQQDFLRF-amide. (150 aa)
flp-1FMRFamide-like neuropeptides 1; Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (175 aa)
flp-8FMRFamide-like peptide 8. (135 aa)
nlp-18Neuropeptide-Like Protein. (99 aa)
flp-13FMRFamide-like neuropeptides 13; FMRFamides and FMRFamide-like peptides are neuropeptides. APEASPFIRF-amide: Inhibits muscle tension in somatic muscle. Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system. [SPSAVPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro. [ASSAPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family. (160 aa)
nlp-24Neuropeptide-Like Protein. (80 aa)
nlp-5Neuropeptide-Like Protein. (123 aa)
nlp-10Neuropeptide-Like Protein. (131 aa)
ntc-1Nematocin; Ligand for the G-protein coupled receptor ntr-1. Plays a role in gustatory associative learning. Also plays a role in male mating behavior. (103 aa)
flp-22FMRFamide-like neuropeptides 22; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family. (93 aa)
sprr-2Sex peptide receptor-related protein 2; G-protein coupled receptor for the neuropeptide like protein nlp-38. Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. Its role in salt avoidance learning may be through activation of the transcription factor crh- 1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory. (451 aa)
nlp-20Neuropeptide-Like Protein. (99 aa)
nlp-37PDF (Arthropod Pigment Dispersing Factor) homolog. (89 aa)
nlp-3Neuropeptide-Like Protein. (90 aa)
flp-7FMRFamide-like neuropeptides 7; FMRFamides and FMRFamide-like peptides are neuropeptides. flp-7 stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss. SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro. [SPMDRSKMVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro. (177 aa)
sto-3Stomatin-3. (267 aa)
F58H1.7Uncharacterized protein. (185 aa)
crf-1Neuropeptide-Like Protein. (72 aa)
K02F2.5Uncharacterized protein. (202 aa)
flp-11FMRFamide-like neuropeptides 11; FMRFamides and FMRFamide-like peptides are neuropeptides. [ASGGMRNALVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family. (110 aa)
flp-25FMRF-Like Peptide. (96 aa)
nlp-19Neuropeptide-Like Protein. (99 aa)
nlp-12Neuropeptide-Like Protein. (80 aa)
M04D8.7Uncharacterized protein. (170 aa)
flp-19FMRFamide-like neuropeptides 19; FMRFamides and FMRFamide-like peptides are neuropeptides. WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (89 aa)
flp-32FMRF-Like Peptide. (81 aa)
flp-34FMRF-Like Peptide. (105 aa)
npr-24G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa)
nlp-67Neuropeptide-Like Protein. (90 aa)
flp-26FMRFamide-like neuropeptides 26; FMRFamides and FMRFamide-like peptides are neuropeptides. (84 aa)
nlp-80Neuropeptide-Like Protein. (76 aa)
flp-10FMRFamide-like peptide 10. (67 aa)
nlp-58Neuropeptide-Like Protein. (94 aa)
flp-33FMRF-Like Peptide. (86 aa)
pdf-1PDF (Arthropod Pigment Dispersing Factor) homolog. (88 aa)
nlp-33Neuropeptide-like protein 33; May have antifungic activity against D.coniospora; Belongs to the YARP (YGGW-amide related peptide) family. (74 aa)
frpr-18G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (432 aa)
ckr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
nlp-6Neuropeptide-Like Protein. (109 aa)
nlp-22Neuropeptide-Like Protein. (102 aa)
nlp-2Neuropeptide-Like Protein. (171 aa)
T27C4.1Uncharacterized protein. (243 aa)
flp-3FMRFamide-like neuropeptides 3; FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (184 aa)
flp-2FMRFamide-like peptide 2a. (106 aa)
flp-28FMRF-Like Peptide. (71 aa)
flp-14FMRFamide-like neuropeptides 14; FMRFamides and FMRFamide-like peptides are neuropeptides. KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system. Functions in RID peptidergic neurons to promote forward locomotory behavior. (143 aa)
ins-16INSulin related. (77 aa)
ckr-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (617 aa)
nlp-17Neuropeptide-Like Protein. (83 aa)
flp-18FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system. (208 aa)
npr-34G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (613 aa)
ndnf-1NDNF (Neuron Derived Neurotrophic Factor) homolog. (536 aa)
npr-5G_PROTEIN_RECEP_F1_2 domain-containing protein. (433 aa)
npr-22Neuropeptide receptor 22; Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior. Receptor for flp-7 which stimulates serotonin-induced fat loss. Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss. Acts in vitro as a receptor for the flp-7 FMRFamide- like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF- amide and SPMDRSKMVRF-amide. Also acts in vitro as a receptor for a number of other FMRFa [...] (434 aa)
nlp-81Neuropeptide-Like Protein. (78 aa)
pghm-1Probable peptidylglycine alpha-hydroxylating monooxygenase 1; Monooxygenase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Produces an unstable peptidyl(2- hydroxyglycine) intermediate. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (324 aa)
nlp-71Neuropeptide-Like Protein. (88 aa)
npr-9Galanin-like G-protein coupled receptor npr-9; Neuropeptide that controls movement such as roaming, foraging and backwards locomotion or 'reversals' in response to environmental cues such as food availability or volatile odorants such as octanol. Antagonizes AIB interneuron activity to control bacterial colonization and may negatively regulate the expression of immunity-related genes such as pqm-1 and dod-22 in response to infection by P.aeruginosa. (444 aa)
flp-15FMRF-Like Peptide. (87 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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