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| | crm-1 | CRiM (Cysteine Rich motor neuron protein) homolog. (966 aa) |
| | wrm-1 | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (796 aa) |
| | vang-1 | Vang-like protein. (532 aa) |
| | daf-7 | Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa) |
| | tin-9.2 | Mitochondrial import inner membrane translocase subunit Tim10B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity). (111 aa) |
| | cam-1 | Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa) |
| | kin-19 | Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (341 aa) |
| | nhr-148 | Nuclear Hormone Receptor family. (370 aa) |
| | nhr-147 | Nuclear Hormone Receptor family. (373 aa) |
| | daf-4 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (744 aa) |
| | nhr-150 | Nuclear hormone receptor family member nhr-150; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (342 aa) |
| | npax-4 | Paired domain-containing protein. (202 aa) |
| | nhr-152 | Nuclear Hormone Receptor family. (383 aa) |
| | nhr-94 | NR LBD domain-containing protein. (338 aa) |
| | nhr-136 | Nuclear hormone receptor family member nhr-136; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (435 aa) |
| | nhr-155 | Nuclear Hormone Receptor family. (361 aa) |
| | lin-18 | Inactive tyrosine-protein kinase RYK; Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis. (583 aa) |
| | nhr-72 | Nuclear hormone receptor family member nhr-75; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (324 aa) |
| | nhr-157 | Nuclear Hormone Receptor family. (366 aa) |
| | nhr-158 | Nuclear Hormone Receptor family. (359 aa) |
| | nhr-159 | Nuclear Hormone Receptor family. (359 aa) |
| | hlh-14 | BHLH domain-containing protein. (148 aa) |
| | elf-1 | ETS domain-containing protein. (420 aa) |
| | nhr-30 | Nuclear Hormone Receptor family. (416 aa) |
| | C25G6.3 | Uncharacterized protein. (578 aa) |
| | dsh-2 | DiSHevelled related. (759 aa) |
| | ceh-43 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. (282 aa) |
| | nhr-138 | Nuclear Hormone Receptor family. (410 aa) |
| | srt-58 | Nuclear receptor domain-containing protein. (213 aa) |
| | sma-6 | Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (636 aa) |
| | nhr-2 | Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (472 aa) |
| | nhr-42 | Nuclear hormone receptor family member nhr-42; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (356 aa) |
| | nhr-161 | Nuclear Hormone Receptor family. (337 aa) |
| | cnd-1 | Neurogenic differentiation factor 1; Acts as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding. (192 aa) |
| | dsh-1 | DiSHevelled related. (981 aa) |
| | hen-1 | HEsitatioN behavior. (117 aa) |
| | pry-1 | Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity. (586 aa) |
| | nhr-260 | Nuclear Hormone Receptor family. (398 aa) |
| | ets-5 | ETS domain-containing transcription factor ets-5; Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons. The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels. Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons. Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons. May mediate tra [...] (246 aa) |
| | C44H4.6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (367 aa) |
| | nhr-64 | Nuclear hormone receptor family member nhr-64; Orphan nuclear receptor. (375 aa) |
| | mam-2 | MAM domain-containing protein. (774 aa) |
| | nhr-166 | Nuclear Hormone Receptor family. (363 aa) |
| | nhr-167 | Nuclear hormone receptor family member nhr-167; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (343 aa) |
| | ets-8 | ETS domain-containing protein. (141 aa) |
| | ets-9 | ETS domain-containing protein. (396 aa) |
| | unc-129 | TGF_BETA_2 domain-containing protein. (407 aa) |
| | bar-1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (811 aa) |
| | nhr-171 | Nuclear Hormone Receptor family. (386 aa) |
| | nhr-137 | NR LBD domain-containing protein. (432 aa) |
| | aka-1 | FYVE-type domain-containing protein. (1284 aa) |
| | hlh-16 | BHLH domain-containing protein. (146 aa) |
| | pqn-26 | Glutaredoxin domain-containing protein. (664 aa) |
| | lin-44 | Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (348 aa) |
| | daf-14 | MH2 domain-containing protein. (331 aa) |
| | adt-2 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. (1020 aa) |
| | clec-54 | C-type LECtin. (381 aa) |
| | nhr-262 | Nuclear Hormone Receptor family. (389 aa) |
| | nhr-118 | Nuclear Hormone Receptor family. (363 aa) |
| | nhr-264 | Nuclear Hormone Receptor family. (358 aa) |
| | nhr-281 | Nuclear Hormone Receptor family. (382 aa) |
| | F19F10.1 | ETS domain-containing protein. (210 aa) |
| | ets-7 | ETS domain-containing protein. (218 aa) |
| | nhr-21 | NR LBD domain-containing protein. (450 aa) |
| | npax-1 | Paired domain-containing protein. (176 aa) |
| | bra-2 | MYND-type domain-containing protein. (214 aa) |
| | daf-3 | Dwarfin sma. (895 aa) |
| | F26F4.8 | Uncharacterized protein. (302 aa) |
| | cfz-2 | Frizzled-2; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta- catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to inv [...] (578 aa) |
| | daf-1 | Cell surface receptor daf-1; Controls the dauer/nondauer developmental decision in a range of environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. (669 aa) |
| | moe-3 | CCCH-type zinc finger protein moe-3; Zinc-finger protein that may play a role in oocyte maturation and fertility. (367 aa) |
| | nhr-15 | Nuclear Hormone Receptor family. (371 aa) |
| | nhr-108 | Nuclear hormone receptor family member nhr-108; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (338 aa) |
| | tag-68 | Dwarfin sma. (415 aa) |
| | hlh-31 | BHLH domain-containing protein. (164 aa) |
| | mom-2 | Protein mom-2; Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such [...] (362 aa) |
| | tig-2 | TGF_BETA_2 domain-containing protein. (366 aa) |
| | sox-3 | HMG box domain-containing protein. (212 aa) |
| | nhr-82 | Nuclear Hormone Receptor family. (326 aa) |
| | nhr-265 | Nuclear Hormone Receptor family. (348 aa) |
| | nhr-39 | Nuclear Hormone Receptor family. (384 aa) |
| | nhr-18 | Nuclear hormone receptor family member nhr-18; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (394 aa) |
| | nhr-103 | Nuclear hormone receptor family member nhr-103; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (394 aa) |
| | nhr-186 | Nuclear Hormone Receptor family. (370 aa) |
| | nhr-187 | Nuclear Hormone Receptor family. (357 aa) |
| | nhr-188 | Nuclear Hormone Receptor family. (353 aa) |
| | lon-1 | Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family. (312 aa) |
| | ztf-11 | Zinc finger protein ztf-11; Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis. Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis. Required for the generation of postembryonic neurons from epidermal cells. Belongs to the MYT1 family. (539 aa) |
| | bra-1 | MYND-type domain-containing protein. (183 aa) |
| | unc-39 | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. (335 aa) |
| | nhr-283 | Nuclear Hormone Receptor family. (327 aa) |
| | nhr-192 | Nuclear Hormone Receptor family. (352 aa) |
| | scd-1 | Suppressor of Constitutive Dauer formation. (947 aa) |
| | nhr-97 | Nuclear hormone receptor family member nhr-97; Orphan nuclear receptor. (439 aa) |
| | nhr-38 | Nuclear receptor domain-containing protein. (355 aa) |
| | apr-1 | Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa) |
| | nhr-51 | Nuclear hormone receptor family member nhr-51; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (371 aa) |
| | nhr-53 | Nuclear hormone receptor family member nhr-53; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (364 aa) |
| | nhr-196 | Nuclear Hormone Receptor family. (340 aa) |
| | nhr-197 | Nuclear hormone receptor family member nhr-197; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (340 aa) |
| | nhr-198 | Nuclear Hormone Receptor family. (378 aa) |
| | pax-2 | Paired domain-containing protein. (351 aa) |
| | K09F5.1 | Uncharacterized protein. (361 aa) |
| | cwn-1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1. Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. Also acts with the Wnt ligand egl-20 to direct HSN neuron migration. Acts [...] (372 aa) |
| | nhr-119 | Nuclear Hormone Receptor family. (708 aa) |
| | hlh-2 | BHLH domain-containing protein. (399 aa) |
| | R03D7.5 | Putative serine/threonine-protein kinase R03D7.5; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (363 aa) |
| | nhr-205 | Nuclear Hormone Receptor family. (387 aa) |
| | daf-8 | Dwarfin sma. (546 aa) |
| | mig-14 | Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa) |
| | R07B7.12 | Glycosyltransferase family 92 protein R07B7.12. (550 aa) |
| | nhr-206 | Nuclear Hormone Receptor family. (410 aa) |
| | nhr-207 | Nuclear Hormone Receptor family. (406 aa) |
| | nhr-208 | Nuclear Hormone Receptor family. (410 aa) |
| | nhr-269 | Nuclear Hormone Receptor family. (334 aa) |
| | sma-4 | Dwarfin sma-4; Involved in TGF-beta pathway; Belongs to the dwarfin/SMAD family. (565 aa) |
| | npax-3 | Paired domain-containing protein. (205 aa) |
| | nhr-270 | Nuclear Hormone Receptor family. (399 aa) |
| | sma-3 | Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family. (393 aa) |
| | sma-9 | SMAll. (2232 aa) |
| | mig-5 | Segment polarity protein dishevelled homolog mig-5; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Functions redundantly with other dishevelled family members throughout development. During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells. In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the cor [...] (672 aa) |
| | hlh-4 | Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...] (205 aa) |
| | nhr-84 | Nuclear Hormone Receptor family. (416 aa) |
| | mom-1 | Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle [...] (442 aa) |
| | ast-1 | ETS domain-containing protein. (377 aa) |
| | scd-2 | ALK tyrosine kinase receptor homolog scd-2; Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway. Regulates integration of conflicting sensory cues in AIA interneurons. May act as a receptor for hen-1. (1421 aa) |
| | nhr-16 | Nuclear hormone receptor family member nhr-16; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (388 aa) |
| | nhr-218 | Nuclear hormone receptor family member nhr-218; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (391 aa) |
| | T13H5.1 | Tyrosine-protein phosphatase. (864 aa) |
| | peb-1 | FLYWCH-type domain-containing protein. (427 aa) |
| | lin-32 | Protein lin-32; Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs. Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis. (142 aa) |
| | sma-10 | Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. (881 aa) |
| | mom-5 | Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa) |
| | sys-1 | SYmmetrical Sister cell hermaphrodite gonad defect. (811 aa) |
| | nhr-222 | Nuclear Hormone Receptor family. (343 aa) |
| | nhr-221 | Nuclear Hormone Receptor family. (398 aa) |
| | hlh-3 | Helix-loop-helix protein 3; Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under f [...] (170 aa) |
| | dbl-1 | TGF_BETA_2 domain-containing protein. (365 aa) |
| | nhr-285 | Nuclear Hormone Receptor family. (326 aa) |
| | cwn-2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1. In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore. Together with Wnt ligand cwn- [...] (360 aa) |
| | daf-5 | C-SKI_SMAD_bind domain-containing protein. (627 aa) |
| | ceh-32 | Homeobox protein ceh-32; Plays a role in head morphogenesis, expression is regulated by vab-3. (439 aa) |
| | lit-1 | Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis. (634 aa) |
| | egl-20 | Wnt homolog. (393 aa) |
| | pop-1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa) |
| | gsk-3 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (362 aa) |
| | mig-1 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa) |
| | nhr-145 | NR LBD domain-containing protein. (407 aa) |
| | nhr-146 | Nuclear Hormone Receptor family. (365 aa) |
| | nhr-87 | Nuclear Hormone Receptor family. (363 aa) |
| | tig-3 | TGF_BETA_2 domain-containing protein. (251 aa) |
| | nhr-238 | Nuclear Hormone Receptor family. (333 aa) |
| | csp-1 | Caspase A subunit p14; Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels. (536 aa) |
| | mab-31 | Uncharacterized protein. (427 aa) |
| | nhr-239 | Nuclear receptor domain-containing protein. (262 aa) |
| | feh-1 | Protein Fe65 homolog; Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2. (665 aa) |
| | lin-22 | BHLH domain-containing protein. (173 aa) |
| | nhr-242 | Nuclear Hormone Receptor family. (305 aa) |
| | ngn-1 | BHLH domain-containing protein. (184 aa) |
| | nhr-241 | Nuclear receptor domain-containing protein. (331 aa) |
| | lin-17 | Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | drag-1 | RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family. (408 aa) |
| | sfrp-1 | NTR domain-containing protein. (314 aa) |
| | mam-1 | MAM domain-containing protein. (761 aa) |
| | ZK1037.13 | Nuclear receptor domain-containing protein. (291 aa) |
| | obr-3 | PH domain-containing protein. (770 aa) |
| | nhr-248 | Nuclear Hormone Receptor family. (342 aa) |
| | sma-2 | Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis. (418 aa) |
| | prkl-1 | Drosophila PRicKLe homolog. (523 aa) |
| | nhr-9 | Nuclear hormone receptor family member nhr-9; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (332 aa) |
| | nhr-252 | Nuclear Hormone Receptor family. (347 aa) |
| | nhr-253 | Nuclear Hormone Receptor family. (345 aa) |
| | nhr-254 | Nuclear Hormone Receptor family. (345 aa) |
| | nhr-255 | Nuclear Hormone Receptor family. (342 aa) |
| | hlh-10 | BHLH domain-containing protein. (202 aa) |
| | nhr-256 | NR LBD domain-containing protein. (431 aa) |
| | lon-3 | Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape. (324 aa) |
