STRINGSTRING
szy-20 szy-20 gip-2 gip-2 sas-4 sas-4 zyg-9 zyg-9 spd-2 spd-2 sas-5 sas-5 ptrn-1 ptrn-1 spd-5 spd-5 tbg-1 tbg-1 zyg-1 zyg-1 gip-1 gip-1 air-1 air-1 sas-7 sas-7 noca-1 noca-1 W03G9.8 W03G9.8 tpxl-1 tpxl-1 sas-6 sas-6 rsa-2 rsa-2 tac-1 tac-1 ebp-1 ebp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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szy-20Suppressor of zyg-1 protein 20; RNA binding protein that is required for normal cell division and cytokinesis during embryonic development. Functions with RNA-binding protein atx-2 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Furthermore, negatively regulates the levels of the protein kinase zyg-1 at the centrosome. Also involved in ensuring centrosome attachment to the nuclear envelope. (563 aa)
gip-2Gamma-tubulin interacting protein 2; Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules. (642 aa)
sas-4Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. (808 aa)
zyg-9Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. (1415 aa)
spd-2Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa)
sas-5Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. (404 aa)
ptrn-1Patronin (microtubule-binding protein) homolog; Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Play [...] (1112 aa)
spd-5Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. (1198 aa)
tbg-1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (444 aa)
zyg-1Probable serine/threonine-protein kinase zyg-1; Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome. Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, whic [...] (706 aa)
gip-1Gamma-tubulin complex component. (963 aa)
air-1Protein kinase domain-containing protein. (326 aa)
sas-7Uncharacterized protein. (1013 aa)
noca-1Non-centrosomal microtubule array protein 1; Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis. Required for microtubule stability and anchorage by binding to microtubule minus ends. Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules. [Isoform h]: Directs the assembly of non-centrosomal microtubule array [...] (922 aa)
W03G9.8Mitotic spindle organiZing protein (MOZART) homolog. (67 aa)
tpxl-1TPX2 (Targeting Protein for Xenopus Klp2)-Like. (507 aa)
sas-6Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. (492 aa)
rsa-2Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. (949 aa)
tac-1Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] (260 aa)
ebp-1Microtubule End Binding Protein. (316 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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