STRINGSTRING
clec-51 clec-51 C01B10.6 C01B10.6 amt-1 amt-1 C08H9.1 C08H9.1 asp-9 asp-9 C12D12.1 C12D12.1 lec-9 lec-9 C18B2.5 C18B2.5 hop-1 hop-1 cpr-6 cpr-6 C26B9.5 C26B9.5 C32B5.7 C32B5.7 C49C3.4 C49C3.4 cpr-1 cpr-1 F09B12.3 F09B12.3 ttr-41 ttr-41 F14B8.6 F14B8.6 F15D4.4 F15D4.4 nep-11 nep-11 F19C7.1 F19C7.1 asp-5 asp-5 asp-12 asp-12 asp-6 asp-6 pcp-3 pcp-3 F26E4.4 F26E4.4 asp-13 asp-13 F28B4.3 F28B4.3 F32A5.3 F32A5.3 cpz-1 cpz-1 F32H5.1 F32H5.1 clec-63 clec-63 sel-12 sel-12 cpr-2 cpr-2 irg-7 irg-7 F41C3.5 F41C3.5 tag-196 tag-196 nas-28 nas-28 cpr-4 cpr-4 F44E7.4 F44E7.4 F46G10.1 F46G10.1 F49E2.2 F49E2.2 F52E1.14 F52E1.14 F54D5.3 F54D5.3 F54D5.4 F54D5.4 nep-17 nep-17 drd-5 drd-5 F56C9.7 F56C9.7 F56F10.1 F56F10.1 F57F4.4 F57F4.4 F57F5.1 F57F5.1 asp-7 asp-7 asp-8 asp-8 asp-3 asp-3 H34I24.2 H34I24.2 K04A8.18 K04A8.18 K10C2.1 K10C2.1 asp-14 asp-14 nas-11 nas-11 K12H4.7 K12H4.7 LLC1.2 LLC1.2 M28.10 M28.10 lec-8 lec-8 R07E3.1 R07E3.1 R08E3.1 R08E3.1 R09F10.1 R09F10.1 R10H10.3 R10H10.3 R12C12.9 R12C12.9 asp-4 asp-4 cpl-1 cpl-1 nep-2 nep-2 ttr-46 ttr-46 cpr-3 cpr-3 nep-21 nep-21 asp-2 asp-2 trd-1 trd-1 T20D3.2 T20D3.2 nep-22 nep-22 T25C12.3 T25C12.3 T25F10.3 T25F10.3 pen-2 pen-2 T28F3.8 T28F3.8 T28H10.3 T28H10.3 aph-1 aph-1 lec-10 lec-10 cpr-5 cpr-5 zmp-4 zmp-4 Y119D3B.21 Y119D3B.21 Y16B4A.2 Y16B4A.2 Y32F6A.4 Y32F6A.4 srp-3 srp-3 Y34B4A.6 Y34B4A.6 Y34B4A.9 Y34B4A.9 Y34F4.1 Y34F4.1 asp-1 asp-1 asp-15 asp-15 asp-16 asp-16 asp-17 asp-17 ctsa-2 ctsa-2 Y40H7A.10 Y40H7A.10 Y43C5A.2 Y43C5A.2 Y51A2D.1 Y51A2D.1 gst-29 gst-29 Y54F10AM.8 Y54F10AM.8 lec-6 lec-6 Y65B4A.2 Y65B4A.2 Y66H1A.5 Y66H1A.5 Y71H2AM.25 Y71H2AM.25 Y71H2AR.2 Y71H2AR.2 aph-2 aph-2 pcp-1 pcp-1 lec-5 lec-5 ZK1320.2 ZK1320.2 ZK1320.3 ZK1320.3 nep-1 nep-1 asp-18 asp-18 asp-19 asp-19 spe-4 spe-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
clec-51C-type LECtin. (308 aa)
C01B10.6EGF-like domain-containing protein. (506 aa)
amt-1Putative ammonium transporter 1; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (534 aa)
C08H9.1Serine carboxypeptidase ctsa-3.2; Belongs to the peptidase S10 family. (505 aa)
asp-9Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
C12D12.1Uncharacterized protein. (825 aa)
lec-9Galectin. (140 aa)
C18B2.5Uncharacterized protein. (699 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
C26B9.5Uncharacterized protein. (516 aa)
C32B5.7Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (234 aa)
C49C3.4Uncharacterized protein. (1566 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
F09B12.3Putative phospholipase B-like 2; Putative phospholipase; Belongs to the phospholipase B-like family. (582 aa)
ttr-41TransThyretin-Related family domain. (140 aa)
F14B8.6Uncharacterized protein. (345 aa)
F15D4.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (608 aa)
nep-11Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa)
F19C7.1Uncharacterized protein. (266 aa)
asp-5Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (393 aa)
asp-12Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-6Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family. (389 aa)
pcp-3Prolyl Carboxy Peptidase like. (1080 aa)
F26E4.4Uncharacterized protein. (408 aa)
asp-13Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa)
F28B4.3Uncharacterized protein. (2229 aa)
F32A5.3Serine carboxypeptidase ctsa-3.1; Belongs to the peptidase S10 family. (574 aa)
cpz-1Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
clec-63C-type LECtin. (411 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
irg-7Protein irg-7; Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity. (2217 aa)
F41C3.5Serine carboxypeptidase ctsa-1.1; Belongs to the peptidase S10 family. (469 aa)
tag-196Uncharacterized protein; Belongs to the peptidase C1 family. (477 aa)
nas-28Zinc metalloproteinase nas-28; Metalloprotease. (497 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
F44E7.4Uncharacterized protein; Belongs to the peptidase M16 family. (1067 aa)
F46G10.1BTB domain-containing protein. (178 aa)
F49E2.2SH3 domain-containing protein. (576 aa)
F52E1.14Uncharacterized protein. (203 aa)
F54D5.3Uncharacterized protein. (186 aa)
F54D5.4Uncharacterized protein. (186 aa)
nep-17NEPrilysin metallopeptidase family. (1589 aa)
drd-5Dietary restriction down regulated. (331 aa)
F56C9.7Uncharacterized protein. (237 aa)
F56F10.1Putative serine protease F56F10.1; Belongs to the peptidase S28 family. (540 aa)
F57F4.4Uncharacterized protein. (2090 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
asp-7Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (380 aa)
asp-8Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (386 aa)
asp-3Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
H34I24.2Uncharacterized protein. (458 aa)
K04A8.18Saposin B-type domain-containing protein. (131 aa)
K10C2.1Carboxypeptidase; Belongs to the peptidase S10 family. (2314 aa)
asp-14Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
nas-11Zinc metalloproteinase nas-11; Metalloprotease. (579 aa)
K12H4.7Putative serine protease K12H4.7. (510 aa)
LLC1.2Uncharacterized protein. (272 aa)
M28.10Uncharacterized protein. (250 aa)
lec-8Probable galaptin lec-8. (180 aa)
R07E3.1Uncharacterized protein; Belongs to the peptidase C1 family. (402 aa)
R08E3.1Uncharacterized protein. (1943 aa)
R09F10.1Uncharacterized protein; Belongs to the peptidase C1 family. (383 aa)
R10H10.3Uncharacterized protein. (364 aa)
R12C12.9Uncharacterized protein. (250 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
nep-2Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa)
ttr-46Transthyretin-like protein 46. (179 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
nep-21Neprilysin-21; Probable cell surface protease. (856 aa)
asp-2Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (429 aa)
trd-1Tetratricopeptide repeat-containing protein trd-1; Developmental protein required for cell fate determination in both the germline and seam cells of the developing epidermis. Specifically, involved in sex determination and may function in parallel or downstream of other sex determination factors, including tra-2 and fem-3, to promote oogenesis in its role in the regulation of the switch from spermatogenesis to oogenesis in the gonads. Also implicated in the mitosis to meiosis switch in distal tip cells. (771 aa)
T20D3.2Uncharacterized protein. (234 aa)
nep-22NEPrilysin metallopeptidase family. (798 aa)
T25C12.3Uncharacterized protein. (2103 aa)
T25F10.3Uncharacterized protein. (429 aa)
pen-2Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family. (101 aa)
T28F3.8Uncharacterized protein. (485 aa)
T28H10.3Uncharacterized protein. (462 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
lec-10Galectin. (192 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
zmp-4ZnMc domain-containing protein. (472 aa)
Y119D3B.21Uncharacterized protein. (66 aa)
Y16B4A.2Carboxypeptidase; Belongs to the peptidase S10 family. (2161 aa)
Y32F6A.4Aa_trans domain-containing protein. (519 aa)
srp-3Serine or cysteine protease inhibitor; Belongs to the serpin family. (362 aa)
Y34B4A.6Uncharacterized protein. (231 aa)
Y34B4A.9Uncharacterized protein. (225 aa)
Y34F4.1Uncharacterized protein. (198 aa)
asp-1Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family. (396 aa)
asp-15Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
asp-16Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-17Aspartic protease 17; Aspartic proteinase; Belongs to the peptidase A1 family. (391 aa)
ctsa-2Carboxypeptidase; Belongs to the peptidase S10 family. (512 aa)
Y40H7A.10Uncharacterized protein; Belongs to the peptidase C1 family. (343 aa)
Y43C5A.2Fibrinogen C-terminal domain-containing protein. (452 aa)
Y51A2D.1Uncharacterized protein; Belongs to the peptidase C1 family. (314 aa)
gst-29Glutathione S-Transferase; Belongs to the GST superfamily. (209 aa)
Y54F10AM.8Putative phospholipase B-like 3; Putative phospholipase; Belongs to the phospholipase B-like family. (581 aa)
lec-6Galectin. (146 aa)
Y65B4A.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (448 aa)
Y66H1A.5Uncharacterized protein. (217 aa)
Y71H2AM.25Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
Y71H2AR.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (345 aa)
aph-2Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (723 aa)
pcp-1Putative serine protease pcp-1; Belongs to the peptidase S28 family. (565 aa)
lec-5Galectin. (314 aa)
ZK1320.2Uncharacterized protein ZK1320.2. (208 aa)
ZK1320.3Uncharacterized protein ZK1320.3. (208 aa)
nep-1Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa)
asp-18Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (392 aa)
asp-19Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (223 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]