STRINGSTRING
C08H9.1 C08H9.1 asp-9 asp-9 hop-1 hop-1 cpr-6 cpr-6 C32B5.7 C32B5.7 cpr-1 cpr-1 F15D4.4 F15D4.4 nep-11 nep-11 asp-5 asp-5 asp-12 asp-12 asp-6 asp-6 asp-13 asp-13 cpz-1 cpz-1 F32H5.1 F32H5.1 sel-12 sel-12 cpr-2 cpr-2 F41C3.5 F41C3.5 tag-196 tag-196 nas-28 nas-28 cpr-4 cpr-4 F44E7.4 F44E7.4 F57F5.1 F57F5.1 asp-7 asp-7 asp-8 asp-8 asp-3 asp-3 K04A8.18 K04A8.18 asp-14 asp-14 nas-11 nas-11 K12H4.7 K12H4.7 R09F10.1 R09F10.1 asp-4 asp-4 cpl-1 cpl-1 nep-2 nep-2 cpr-3 cpr-3 nep-21 nep-21 asp-2 asp-2 pen-2 pen-2 T28H10.3 T28H10.3 aph-1 aph-1 cpr-5 cpr-5 zmp-4 zmp-4 srp-3 srp-3 asp-1 asp-1 asp-15 asp-15 asp-16 asp-16 asp-17 asp-17 Y40H7A.10 Y40H7A.10 Y51A2D.1 Y51A2D.1 Y65B4A.2 Y65B4A.2 Y71H2AM.25 Y71H2AM.25 Y71H2AR.2 Y71H2AR.2 aph-2 aph-2 nep-1 nep-1 asp-18 asp-18 asp-19 asp-19 spe-4 spe-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C08H9.1Serine carboxypeptidase ctsa-3.2; Belongs to the peptidase S10 family. (505 aa)
asp-9Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
C32B5.7Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (234 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
F15D4.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (608 aa)
nep-11Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa)
asp-5Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (393 aa)
asp-12Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-6Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family. (389 aa)
asp-13Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa)
cpz-1Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
F41C3.5Serine carboxypeptidase ctsa-1.1; Belongs to the peptidase S10 family. (469 aa)
tag-196Uncharacterized protein; Belongs to the peptidase C1 family. (477 aa)
nas-28Zinc metalloproteinase nas-28; Metalloprotease. (497 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
F44E7.4Uncharacterized protein; Belongs to the peptidase M16 family. (1067 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
asp-7Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (380 aa)
asp-8Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (386 aa)
asp-3Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
K04A8.18Saposin B-type domain-containing protein. (131 aa)
asp-14Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
nas-11Zinc metalloproteinase nas-11; Metalloprotease. (579 aa)
K12H4.7Putative serine protease K12H4.7. (510 aa)
R09F10.1Uncharacterized protein; Belongs to the peptidase C1 family. (383 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
nep-2Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
nep-21Neprilysin-21; Probable cell surface protease. (856 aa)
asp-2Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (429 aa)
pen-2Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family. (101 aa)
T28H10.3Uncharacterized protein. (462 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
zmp-4ZnMc domain-containing protein. (472 aa)
srp-3Serine or cysteine protease inhibitor; Belongs to the serpin family. (362 aa)
asp-1Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family. (396 aa)
asp-15Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
asp-16Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-17Aspartic protease 17; Aspartic proteinase; Belongs to the peptidase A1 family. (391 aa)
Y40H7A.10Uncharacterized protein; Belongs to the peptidase C1 family. (343 aa)
Y51A2D.1Uncharacterized protein; Belongs to the peptidase C1 family. (314 aa)
Y65B4A.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (448 aa)
Y71H2AM.25Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
Y71H2AR.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (345 aa)
aph-2Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (723 aa)
nep-1Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa)
asp-18Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (392 aa)
asp-19Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (223 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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