STRINGSTRING
asp-9 asp-9 hop-1 hop-1 nep-11 nep-11 asp-12 asp-12 asp-13 asp-13 sel-12 sel-12 cpr-2 cpr-2 cpr-4 cpr-4 F44E7.4 F44E7.4 asp-7 asp-7 asp-8 asp-8 nep-2 nep-2 cpr-3 cpr-3 nep-21 nep-21 pen-2 pen-2 aph-1 aph-1 zmp-4 zmp-4 asp-15 asp-15 asp-16 asp-16 aph-2 aph-2 nep-1 nep-1 asp-18 asp-18 spe-4 spe-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
asp-9Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
nep-11Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa)
asp-12Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-13Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
F44E7.4Uncharacterized protein; Belongs to the peptidase M16 family. (1067 aa)
asp-7Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (380 aa)
asp-8Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (386 aa)
nep-2Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
nep-21Neprilysin-21; Probable cell surface protease. (856 aa)
pen-2Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family. (101 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
zmp-4ZnMc domain-containing protein. (472 aa)
asp-15Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
asp-16Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
aph-2Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (723 aa)
nep-1Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa)
asp-18Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (392 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.