STRINGSTRING
B0303.4 B0303.4 ubc-17 ubc-17 ubc-21 ubc-21 ubc-22 ubc-22 bath-15 bath-15 C16C8.4 C16C8.4 ubc-23 ubc-23 ubr-1 ubr-1 ubc-1 ubc-1 C35B1.2 C35B1.2 uba-1 uba-1 bir-2 bir-2 ubc-6 ubc-6 malt-1 malt-1 ubq-1 ubq-1 ubc-25 ubc-25 uev-3 uev-3 unc-45 unc-45 F32H5.3 F32H5.3 uev-1 uev-1 ubc-20 ubc-20 F40G9.6 F40G9.6 F49C12.9 F49C12.9 ubc-24 ubc-24 F52C6.12 F52C6.12 ubc-7 ubc-7 let-70 let-70 rfp-1 rfp-1 ufd-2 ufd-2 chn-1 chn-1 ubc-26 ubc-26 ubc-15 ubc-15 ubc-16 ubc-16 ubc-13 ubc-13 ubc-19 ubc-19 ubc-3 ubc-3 ubc-8 ubc-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0303.4Uncharacterized protein B0303.4. (616 aa)
ubc-17Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family. (728 aa)
ubc-21Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. (214 aa)
ubc-22UBiquitin Conjugating enzyme. (182 aa)
bath-15BTB and MATH domain-containing protein 15; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (313 aa)
C16C8.4Ubiquitin-like domain-containing protein. (226 aa)
ubc-23UAS domain-containing protein. (395 aa)
ubr-1E3 ubiquitin-protein ligase ubr-1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development. Negatively regulates glutamate metabolism through the aspartate aminotrans [...] (2058 aa)
ubc-1Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
C35B1.2Uncharacterized protein. (562 aa)
uba-1UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1113 aa)
bir-2Baculoviral IAP repeat-containing protein bir-2. (308 aa)
ubc-6UBIQUITIN_CONJUGAT_2 domain-containing protein. (314 aa)
malt-1MALT1 paracaspase homolog. (639 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
ubc-25Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function. (387 aa)
uev-3Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family. (368 aa)
unc-45TPR_REGION domain-containing protein. (961 aa)
F32H5.3Uncharacterized protein. (99 aa)
uev-1Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] (139 aa)
ubc-20UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
F40G9.6Uncharacterized protein. (156 aa)
F49C12.9UBA domain-containing protein. (305 aa)
ubc-24UBIQUITIN_CONJUGAT_2 domain-containing protein. (160 aa)
F52C6.12UBIQUITIN_CONJUGAT_2 domain-containing protein. (78 aa)
ubc-7Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. (164 aa)
let-70Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
rfp-1E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family. (837 aa)
ufd-2Ubiquitin conjugation factor E4 ufd-2; Acts as an E4 ubiquitin ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. The elongation of preexisting ubiquitin chains preferentially targets ubiquitin 'Lys-29' and 'Lys-48' residues. Also functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Probably by regulating protein ubiquitination at DNA damage repair sites, coordinates DNA double- strand-break repair and apoptosis in the germline. Required for germline apoptosis in response to DNA damage downstream of cep [...] (984 aa)
chn-1C-term of Hsp70-iNteracting protein (CHIP family). (266 aa)
ubc-26UBIQUITIN_CONJUGAT_2 domain-containing protein. (238 aa)
ubc-15UBIQUITIN_CONJUGAT_2 domain-containing protein. (551 aa)
ubc-16Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Together with ubc-18, required for the ubiquitination of membranous organelles, and the removal of paternal mitochondria from early embryos. (152 aa)
ubc-13Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa)
ubc-19UBIQUITIN_CONJUGAT_2 domain-containing protein. (292 aa)
ubc-3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (243 aa)
ubc-8UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (216 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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