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egg-1 egg-1 puf-7 puf-7 cpg-1 cpg-1 oma-1 oma-1 clec-87 clec-87 mesp-1 mesp-1 gln-6 gln-6 nasp-2 nasp-2 EEED8.3 EEED8.3 F18A1.7 F18A1.7 gfat-2 gfat-2 gln-5 gln-5 pos-1 pos-1 puf-5 puf-5 cbd-1 cbd-1 memi-3 memi-3 egg-5 egg-5 T01C3.3 T01C3.3 rme-2 rme-2 T22D1.5 T22D1.5 mex-5 mex-5 era-1 era-1 W05F2.3 W05F2.3 oma-2 oma-2 clec-91 clec-91
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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egg-1LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] (551 aa)
puf-7Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
cpg-1Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. (584 aa)
oma-1CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa)
clec-87C-type lectin domain-containing protein 87. (233 aa)
mesp-1MEiotic SPindle. (193 aa)
gln-6Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (368 aa)
nasp-2SHNi-TPR domain-containing protein. (582 aa)
EEED8.3Uncharacterized protein EEED8.3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (194 aa)
F18A1.7CPG4 domain-containing protein. (266 aa)
gfat-2Glutamine-Fructose 6-phosphate AminoTransferase homolog. (710 aa)
gln-5Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (369 aa)
pos-1Cytoplasmic zinc-finger protein. (264 aa)
puf-5Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (553 aa)
cbd-1Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. (1319 aa)
memi-3MEiosis-to-MItosis transition associated. (344 aa)
egg-5Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. (753 aa)
T01C3.3RING-type domain-containing protein. (230 aa)
rme-2Receptor Mediated Endocytosis. (925 aa)
T22D1.5Uncharacterized protein. (391 aa)
mex-5Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. (468 aa)
era-1Embryonic mRna (mRNA) Anterior. (388 aa)
W05F2.3Uncharacterized protein. (222 aa)
oma-2CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa)
clec-91C-type lectin domain-containing protein 91. (225 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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