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lab-1 lab-1 xnd-1 xnd-1 syp-2 syp-2 sgo-1 sgo-1 dsb-1 dsb-1 coh-3 coh-3 msh-5 msh-5 dsb-2 dsb-2 syp-3 syp-3 htp-1 htp-1 gsp-2 gsp-2 sun-1 sun-1 htp-3 htp-3 syp-4 syp-4 zhp-3 zhp-3 rmh-1 rmh-1 spo-11 spo-11 zim-2 zim-2 zim-3 zim-3 him-8 him-8 zim-1 zim-1 him-17 him-17 rec-8 rec-8 coh-4 coh-4 Y54E10A.12 Y54E10A.12 cosa-1 cosa-1 htp-2 htp-2 him-14 him-14 him-3 him-3 zyg-12 zyg-12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lab-1Long arms of the bivalent protein 1; Involved in sister chromatid cohesion during mitosis and meiosis. In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. This in turn, drives germ cell immortality. Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis. (161 aa)
xnd-1X chromosome NonDisjunction factor. (702 aa)
syp-2Uncharacterized protein. (213 aa)
sgo-1Shugoshin; Component of cell cycle checkpoints, which ensures chromosome segregation during meiosis and mitosis. During meiotic prophase, it is involved in the regulation of the synapsis checkpoint, which monitors whether homologous chromosomes have synapsed, and the DNA damage response. Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex after prophase, when most of cohesin complex dissociates from chromosomes arms (By similarity). Belongs to the shugoshin family. (309 aa)
dsb-1Double-Strand Break factor. (385 aa)
coh-3Rad21_Rec8 domain-containing protein. (607 aa)
msh-5MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. (1369 aa)
dsb-2Double-Strand Break factor. (280 aa)
syp-3Uncharacterized protein. (224 aa)
htp-1HORMA domain-containing protein. (352 aa)
gsp-2Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...] (333 aa)
sun-1Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa)
htp-3HORMA domain-containing protein. (739 aa)
syp-4Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination. (605 aa)
zhp-3RING-type domain-containing protein. (389 aa)
rmh-1DUF1767 domain-containing protein. (926 aa)
spo-11Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. (425 aa)
zim-2C2H2-type domain-containing protein. (584 aa)
zim-3Zinc finger In Meiosis. (581 aa)
him-8C2H2-type domain-containing protein. (361 aa)
zim-1C2H2-type domain-containing protein. (606 aa)
him-17High Incidence of Males (Increased X chromosome loss). (954 aa)
rec-8Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. (781 aa)
coh-4Rad21_Rec8 domain-containing protein. (609 aa)
Y54E10A.12Uncharacterized protein. (547 aa)
cosa-1CrossOver Site Associated. (360 aa)
htp-2HORMA domain-containing protein. (352 aa)
him-14MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. (842 aa)
him-3HORMA domain-containing protein. (291 aa)
zyg-12Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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