STRINGSTRING
henn-1 henn-1 C04F12.1 C04F12.1 ppw-1 ppw-1 drh-3 drh-3 drh-1 drh-1 ekl-1 ekl-1 ego-1 ego-1 rrf-1 rrf-1 drsh-1 drsh-1 sago-2 sago-2 rde-1 rde-1 sago-1 sago-1 dcr-1 dcr-1 rrf-2 rrf-2 ergo-1 ergo-1 alg-2 alg-2 rde-4 rde-4 pash-1 pash-1 alg-3 alg-3 wago-10 wago-10 alg-5 alg-5 ppw-2 ppw-2 alg-4 alg-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
henn-1Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa)
C04F12.1Piwi domain-containing protein. (944 aa)
ppw-1Piwi-like protein; Belongs to the argonaute family. (887 aa)
drh-3Dicer Related Helicase. (1119 aa)
drh-1Dicer-related helicase. (1037 aa)
ekl-1Uncharacterized protein. (606 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
rrf-1RNA-dependent RNA polymerase Family. (1601 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
sago-2Piwi-like protein; Belongs to the argonaute family. (887 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
sago-1Piwi-like protein; Belongs to the argonaute family. (881 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
rrf-2RNA-dependent RNA polymerase Family. (1579 aa)
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)
alg-2Protein argonaute; Belongs to the argonaute family. (910 aa)
rde-4RNA interference promoting factor. (385 aa)
pash-1PArtner of DroSHa (DRSH-1 interactor). (751 aa)
alg-3Argonaute (Plant)-Like protein. (1035 aa)
wago-10Piwi-like protein; Belongs to the argonaute family. (990 aa)
alg-5Protein argonaute; Belongs to the argonaute family. (905 aa)
ppw-2Piwi-like protein; Belongs to the argonaute family. (975 aa)
alg-4Putative protein tag-76. (1040 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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