(112 nodes) Preribosome, and Nucleolus network (Caenorhabditis elegans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	B0280.9	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family. (429 aa)
	B0511.6	RNA helicase. (544 aa)
	rpl-24.2	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity). (162 aa)
	krr-1	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (370 aa)
	rha-2	Putative ATP-dependent RNA helicase rha-2; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. (1148 aa)
	pro-2	Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation. (715 aa)
	rrbs-1	Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (333 aa)
	let-716	Uncharacterized protein. (1743 aa)
	C16A3.4	C2H2-type domain-containing protein. (375 aa)
	C16A3.6	Protein MAK16 homolog; Belongs to the MAK16 family. (323 aa)
	C16C10.2	Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (262 aa)
	C18A3.3	Probable rRNA-processing protein EBP2 homolog; Required for the processing of the 27S pre-rRNA. (340 aa)
	C24H12.4	Helicase C-terminal domain-containing protein. (634 aa)
	C27F2.4	Uncharacterized protein. (283 aa)
	pqn-20	Prion-like-(Q/N-rich)-domain-bearing protein. (1254 aa)
	C37H5.5	Nucleolar complex protein 3 homolog. (778 aa)
	C43E11.9	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	eif-6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa)
	rrp-1	Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family. (397 aa)
	C48B6.2	Putative 40S ribosomal protein S4-like. (183 aa)
	lpd-2	LiPid Depleted. (318 aa)
	C53H9.2	CP-type G domain-containing protein. (554 aa)
	E02H1.1	Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. (308 aa)
	F10E7.5	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa)
	F10E7.6	Uncharacterized protein. (153 aa)
	tag-151	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. (785 aa)
	rbm-34	RNA Binding Motif protein homolog. (394 aa)
	F13H8.2	WD_REPEATS_REGION domain-containing protein. (929 aa)
	utp-20	DRIM domain-containing protein. (2613 aa)
	F23B12.7	Uncharacterized protein F23B12.7; Belongs to the CBF/MAK21 family. (953 aa)
	F27C1.6	Uncharacterized protein. (647 aa)
	F28B3.10	Uncharacterized protein. (155 aa)
	F28B3.6	Uncharacterized protein. (167 aa)
	wdr-46	WD_REPEATS_REGION domain-containing protein. (580 aa)
	F30A10.9	PINc domain-containing protein. (196 aa)
	nol-10	NUC153 domain-containing protein. (754 aa)
	F44G4.1	Brix domain-containing protein F44G4.1. (384 aa)
	F44G4.2	Probable NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (160 aa)
	F49D11.10	Uncharacterized protein. (727 aa)
	F53E10.6	RRP15-like protein; Belongs to the RRP15 family. (191 aa)
	F53F4.11	Uncharacterized protein. (543 aa)
	nath-10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1043 aa)
	F55F8.2	Uncharacterized protein. (746 aa)
	F55F8.3	Periodic tryptophan protein 2 homolog; Belongs to the WD repeat PWP2 family. (910 aa)
	wdr-12	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (439 aa)
	byn-1	Uncharacterized protein byn-1; Belongs to the bystin family. (449 aa)
	H06I04.3	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (833 aa)
	H20J04.4	Uncharacterized protein; Belongs to the DEAD box helicase family. (561 aa)
	JC8.2	WD_REPEATS_REGION domain-containing protein. (467 aa)
	nst-1	Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues. (556 aa)
	K05C4.5	Uncharacterized protein. (686 aa)
	nol-56	Nucleolar protein 56; Required for 60S ribosomal subunit synthesis. Belongs to the NOP5/NOP56 family. (486 aa)
	lpd-6	Brix domain-containing protein. (573 aa)
	K12H4.3	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (352 aa)
	M28.5	NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
	ddx-52	DEAD boX helicase homolog. (581 aa)
	rbm-28	RNA Binding Motif protein homolog. (608 aa)
	lpd-7	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (531 aa)
	pro-1	Pre-rRNA-processing protein pro-1; Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation. Required in the soma to promote normal proliferation and prevent germline tumor formation. Belongs to the WD repeat IPI3/WDR18 family. (529 aa)
	T01B7.5	Sas10 domain-containing protein. (407 aa)
	trcs-2	TRansport of membrane to Cell Surface. (779 aa)
	fib-1	rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein [...] (352 aa)
	T02H6.1	WD_REPEATS_REGION domain-containing protein. (540 aa)
	nifk-1	RRM domain-containing protein. (307 aa)
	T06E6.1	Uncharacterized protein. (431 aa)
	nog-1	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size. May regulate fat storage via the insulin/IGF pathway. (681 aa)
	T10B5.3	Utp12 domain-containing protein. (295 aa)
	ngp-1	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (651 aa)
	T20B12.3	Uncharacterized protein T20B12.3; Belongs to the CBF/MAK21 family. (504 aa)
	T23D8.3	Protein LTV1 homolog; Belongs to the LTV1 family. (410 aa)
	rbd-1	RBD (RNA binding domain) protein. (872 aa)
	T25G3.3	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (513 aa)
	T26G10.1	Putative ATP-dependent RNA helicase T26G10.1; Probable ATP-dependent RNA helicase which may be involved in ribosome biogenesis. (489 aa)
	nol-58	Nop domain-containing protein. (487 aa)
	nol-2	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (664 aa)
	W07E6.2	WD_REPEATS_REGION domain-containing protein. (473 aa)
	W08E12.7	Peptidase_M24 domain-containing protein. (391 aa)
	W09C5.1	Uncharacterized protein. (259 aa)
	riok-2	Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (529 aa)
	Y23H5B.5	WD_REPEATS_REGION domain-containing protein. (561 aa)
	Y39A1A.14	Ribosomal RNA small subunit methyltransferase nep-1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfami [...] (231 aa)
	pro-3	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm (Probable). Required for normal somatic gonad development and for regulation of germline development and proliferation. (801 aa)
	Y39B6A.33	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit. (438 aa)
	Y41C4A.9	Uncharacterized protein. (577 aa)
	Y45F10D.7	Uncharacterized protein. (924 aa)
	Y46E12BL.2	NUC173 domain-containing protein. (1334 aa)
	Y48A6C.4	Ipi1_N domain-containing protein. (365 aa)
	Y48B6A.1	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (674 aa)
	nol-14	NucleOLar protein. (829 aa)
	Y49F6B.2	Fcf2 domain-containing protein. (252 aa)
	nol-6	Nucleolar protein 6. (1058 aa)
	Y53C12B.1	WD_REPEATS_REGION domain-containing protein. (793 aa)
	pno-1	RNA-binding protein pno-1. (277 aa)
	Y54E10A.10	Ribosome production factor 2 homolog. (297 aa)
	Y54E10BR.4	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (364 aa)
	Y54H5A.1	WD_REPEATS_REGION domain-containing protein. (453 aa)
	Y56A3A.18	Zinc finger protein 593 homolog; Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family. (128 aa)
	Y61A9LA.10	Bms1-type G domain-containing protein. (1055 aa)
	ddx-27	DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (739 aa)
	Y73E7A.2	Uncharacterized protein. (463 aa)
	Y75B8A.7	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (648 aa)
	Y94H6A.5	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (825 aa)
	ZC434.4	Ribosomal RNA-processing protein 7 homolog; Belongs to the RRP7 family. (270 aa)
	ZK1127.5	Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (379 aa)
	toe-1	HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (1650 aa)
	ZK430.7	WD_REPEATS_REGION domain-containing protein. (444 aa)
	ZK512.2	Probable ATP-dependent RNA helicase DDX55 homolog; Probable ATP-binding RNA helicase. (578 aa)
	ZK546.14	Uncharacterized protein ZK546.14. (472 aa)
	riok-3	Serine/threonine-protein kinase RIO3. (510 aa)
	ZK792.5	Uncharacterized protein. (645 aa)
	ZK795.3	Brix domain-containing protein ZK795.3. (292 aa)
	puf-12	Pumilio domain-containing protein 12. (766 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0280.9	B0511.6	B0280.9.1	B0511.6.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	RNA helicase.	0.657
B0280.9	C16A3.4	B0280.9.1	C16A3.4.2	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	C2H2-type domain-containing protein.	0.556
B0280.9	C16A3.6	B0280.9.1	C16A3.6.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.658
B0280.9	C16C10.2	B0280.9.1	C16C10.2.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.995
B0280.9	C18A3.3	B0280.9.1	C18A3.3.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Probable rRNA-processing protein EBP2 homolog; Required for the processing of the 27S pre-rRNA.	0.735
B0280.9	C24H12.4	B0280.9.1	C24H12.4a.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Helicase C-terminal domain-containing protein.	0.599
B0280.9	C27F2.4	B0280.9.1	C27F2.4.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein.	0.648
B0280.9	C37H5.5	B0280.9.1	C37H5.5.2	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Nucleolar complex protein 3 homolog.	0.764
B0280.9	C43E11.9	B0280.9.1	C43E11.9.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.764
B0280.9	C48B6.2	B0280.9.1	C48B6.2.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Putative 40S ribosomal protein S4-like.	0.995
B0280.9	C53H9.2	B0280.9.1	C53H9.2a.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	CP-type G domain-containing protein.	0.528
B0280.9	E02H1.1	B0280.9.1	E02H1.1.2	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.	0.961
B0280.9	F10E7.5	B0280.9.1	F10E7.5.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.669
B0280.9	F10E7.6	B0280.9.1	F10E7.6.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein.	0.591
B0280.9	F13H8.2	B0280.9.1	F13H8.2.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	WD_REPEATS_REGION domain-containing protein.	0.999
B0280.9	F23B12.7	B0280.9.1	F23B12.7.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein F23B12.7; Belongs to the CBF/MAK21 family.	0.815
B0280.9	F27C1.6	B0280.9.1	F27C1.6.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein.	0.997
B0280.9	F28B3.10	B0280.9.1	F28B3.10.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein.	0.892
B0280.9	F28B3.6	B0280.9.1	F28B3.6.2	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	Uncharacterized protein.	0.892
B0280.9	F30A10.9	B0280.9.1	F30A10.9.1	U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.	PINc domain-containing protein.	0.972