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| | B0495.9 | Uncharacterized protein B0495.9. (267 aa) |
| | C04F5.8 | Uncharacterized protein. (342 aa) |
| | tin-9.1 | Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). Belongs to the small Tim family. (78 aa) |
| | dct-1 | NIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions. Belongs to the NIP3 family. (221 aa) |
| | tomm-40 | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development. (301 aa) |
| | haf-1 | HAlF transporter (PGP related). (677 aa) |
| | lonp-1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...] (971 aa) |
| | C34C12.8 | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). (237 aa) |
| | gop-3 | SAM50-like protein gop-3; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family. (434 aa) |
| | hsp-6 | Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family. (657 aa) |
| | C46F11.6 | Ubiquitin-like protein. (121 aa) |
| | C47G2.3 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). (213 aa) |
| | rom-2 | Inactive rhomboid-related protein 2; Probable inactive serine protease. (435 aa) |
| | eat-3 | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (964 aa) |
| | D2030.2 | Uncharacterized protein. (586 aa) |
| | timm-17B.2 | Translocase, Inner Mitochondrial Membrane. (140 aa) |
| | tin-13 | Mitochondrial import inner membrane translocase subunit tim-13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim-8- tim-13 complex mediates the import of some pro [...] (108 aa) |
| | tbc-14 | Rab-GAP TBC domain-containing protein. (630 aa) |
| | timm-17B.1 | Probable mitochondrial import inner membrane translocase subunit tim-17B.1; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane; Belongs to the Tim17/Tim22/Tim23 family. (181 aa) |
| | pink-1 | Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa) |
| | sto-1 | Stomatin-1. (330 aa) |
| | F11C1.1 | CHCH domain-containing protein. (126 aa) |
| | mff-1 | Mitochondrial Fission Factor. (158 aa) |
| | fis-2 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa) |
| | vab-3 | Homeobox domain-containing protein. (455 aa) |
| | timm-23 | Translocase, Inner Mitochondrial Membrane. (242 aa) |
| | romo-1 | (Reactive Oxygen species MOdulator) homolog. (82 aa) |
| | jmjd-3.1 | Lysine-specific demethylase jmjd-3.1; Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell- autonomously in Y-to-PDA tra [...] (1061 aa) |
| | dnj-10 | DnaJ homolog dnj-10. (456 aa) |
| | tomm-20 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. (188 aa) |
| | F25B4.4 | Uncharacterized protein. (218 aa) |
| | rom-1 | Rhomboid-related protein 1; Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs. (356 aa) |
| | jmjd-1.2 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa) |
| | sto-2 | Stomatin-2; May be involved in cilia-related function. (375 aa) |
| | F32B4.2 | Uncharacterized protein. (167 aa) |
| | mtx-1 | Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (312 aa) |
| | fis-1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa) |
| | sto-5 | PHB domain-containing protein. (381 aa) |
| | F42H10.2 | Uncharacterized protein F42H10.2. (115 aa) |
| | F45G2.8 | Mitochondrial import inner membrane translocase subunit tim-16; Regulates ATP-dependent protein translocation into the mitochondrial matrix; Belongs to the TIM16/PAM16 family. (136 aa) |
| | ubl-5 | Ubiquitin-like protein 5. (73 aa) |
| | mff-2 | Mitochondrial Fission Factor. (161 aa) |
| | F56B3.11 | Uncharacterized protein. (213 aa) |
| | F56C11.3 | Sulfhydryl oxidase. (161 aa) |
| | mspn-1 | Mitochondrial sorting homolog; Involved in intramitochondrial sorting of proteins. (342 aa) |
| | K07A3.3 | Uncharacterized protein. (518 aa) |
| | pdr-1 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa) |
| | miro-1 | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (625 aa) |
| | K09F6.5 | Uncharacterized protein. (410 aa) |
| | ymel-1 | ATP-dependent zinc metalloprotease YME1 homolog; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function (By similarity); In the C-terminal section; belongs to the peptidase M41 family. (723 aa) |
| | vdac-1 | Probable voltage-dependent anion-selective channel; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. (283 aa) |
| | pgam-5 | Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (284 aa) |
| | cls-2 | Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development. (1023 aa) |
| | fndc-1 | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. (138 aa) |
| | hcp-2 | HoloCentric chromosome binding Protein. (1295 aa) |
| | tin-44 | Probable mitochondrial import inner membrane translocase subunit tin-44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source. (425 aa) |
| | T09F3.2 | Carrier protein (C2); Belongs to the mitochondrial carrier (TC 2.A.29) family. (384 aa) |
| | drp-1 | Dynamin-Related Protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa) |
| | dnj-21 | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (112 aa) |
| | scpl-4 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane; Belongs to the TIM50 family. (452 aa) |
| | phb-2 | Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. (294 aa) |
| | trak-1 | HAP1 N-terminal domain-containing protein. (607 aa) |
| | mfn-1 | Mitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa) |
| | W04A8.2 | Uncharacterized protein. (258 aa) |
| | tomm-22 | Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor tomm-20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. (109 aa) |
| | Y108F1.1 | annotation not available (238 aa) |
| | rom-3 | Rhomboid domain-containing protein. (861 aa) |
| | rom-4 | Rhomboid domain-containing protein. (1205 aa) |
| | coa-5 | Cytochrome Oxidase Assembly subunits. (96 aa) |
| | Y19D10A.6 | Metalloendopeptidase. (272 aa) |
| | phb-1 | Mitochondrial prohibitin complex protein 1; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. (275 aa) |
| | ppgn-1 | AAA domain-containing protein. (747 aa) |
| | ddp-1 | Mitochondrial import inner membrane translocase subunit Tim8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane (By similarity). Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane (By similarity). Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). The ddp-1/t [...] (83 aa) |
| | hlh-33 | BHLH domain-containing protein. (407 aa) |
| | Y47C4A.1 | Uncharacterized protein. (408 aa) |
| | spg-7 | AFG3-like protein spg-7; Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides. Plays a role in male tail tip morphogenesis. In the C-terminal section; belongs to the peptidase M41 family. (782 aa) |
| | rom-5 | Rhomboid domain-containing protein. (325 aa) |
| | tin-10 | Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). (86 aa) |
| | lin-65 | LIN-65L. (728 aa) |
| | lonp-2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. (773 aa) |
| | Y94A7B.11 | Uncharacterized protein. (69 aa) |
| | atfs-1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] (488 aa) |
| | cls-3 | Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (983 aa) |
| | mtx-2 | Metaxin-2 homolog. (260 aa) |
| | hcp-1 | HoloCentric chromosome binding Protein. (1475 aa) |
| | dve-1 | Homeobox domain-containing protein. (468 aa) |
| | fzo-1 | Transmembrane GTPase fzo-1; Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (774 aa) |
| | tomm-70 | Mitochondrial import receptor subunit tomm-70; Receptor that accelerates the import of all mitochondrial precursor proteins; Belongs to the Tom70 family. (554 aa) |
| | ZK616.2 | Uncharacterized protein. (97 aa) |
| | ZK616.3 | CHCH domain-containing protein. (134 aa) |
| | tomm-7 | Mitochondrial import receptor subunit TOM7 homolog; Belongs to the Tom7 family. (58 aa) |
| | clpp-1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. (221 aa) |
