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moa-2 moa-2 sap-49 sap-49 prp-4 prp-4 prp-8 prp-8 C50D2.5 C50D2.5 snr-4 snr-4 ddx-23 ddx-23 repo-1 repo-1 F19F10.9 F19F10.9 lsm-5 lsm-5 lsm-4 lsm-4 mog-2 mog-2 teg-4 teg-4 prp-3 prp-3 sftb-1 sftb-1 gut-2 gut-2 T13H5.4 T13H5.4 snr-3 snr-3 sftb-2 sftb-2 prp-21 prp-21 snr-2 snr-2 prp-31 prp-31 snr-1 snr-1 snrp-200 snrp-200 snr-6 snr-6 phf-5 phf-5 Y54G2A.75 Y54G2A.75 prp-6 prp-6 lsm-3 lsm-3 snr-7 snr-7 lsm-6 lsm-6 lsm-8 lsm-8 eftu-2 eftu-2 lsm-7 lsm-7 snr-5 snr-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
moa-2Protein moa-2. (87 aa)
sap-49Splicing factor 3B subunit 4; Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). (388 aa)
prp-4WD_REPEATS_REGION domain-containing protein. (496 aa)
prp-8Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. (2329 aa)
C50D2.5Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (138 aa)
snr-4Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). (118 aa)
ddx-23DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa)
repo-1Matrin-type domain-containing protein. (222 aa)
F19F10.9Uncharacterized protein. (829 aa)
lsm-5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family. (91 aa)
lsm-4Probable U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (123 aa)
mog-2Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa)
teg-4CPSF_A domain-containing protein. (1220 aa)
prp-3Yeast PRP (Splicing factor) related. (621 aa)
sftb-1SF3b1 domain-containing protein. (1322 aa)
gut-2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa)
T13H5.4Matrin-type domain-containing protein. (500 aa)
snr-3Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family. (126 aa)
sftb-2PSP domain-containing protein. (602 aa)
prp-21Yeast PRP (Splicing factor) related. (655 aa)
snr-2Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family. (160 aa)
prp-31Nop domain-containing protein. (504 aa)
snr-1Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa)
snrp-200Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2145 aa)
snr-6Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (90 aa)
phf-5PHd Finger family. (110 aa)
Y54G2A.75Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
prp-6Yeast PRP (Splicing factor) related. (968 aa)
lsm-3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
snr-7Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
lsm-6Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
lsm-8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
eftu-2Tr-type G domain-containing protein. (974 aa)
lsm-7Sm domain-containing protein. (104 aa)
snr-5Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (85 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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