STRINGSTRING
bud-31 bud-31 rbmx-2 rbmx-2 C32E8.5 C32E8.5 syf-1 syf-1 plrg-1 plrg-1 cdc-5L cdc-5L F32B6.3 F32B6.3 let-858 let-858 F37C12.1 F37C12.1 mog-3 mog-3 isy-1 isy-1 rnf-113 rnf-113 mog-1 mog-1 syf-2 syf-2 K07C5.6 K07C5.6 M03F8.3 M03F8.3 R08D7.1 R08D7.1 cwc-15 cwc-15 prp-19 prp-19 rbm-22 rbm-22 skp-1 skp-1 cyn-16 cyn-16 Y54G2A.12 Y54G2A.12 rsr-2 rsr-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bud-31Protein BUD31 homolog; Involved in pre-mRNA splicing process. (147 aa)
rbmx-2RRM domain-containing protein. (302 aa)
C32E8.5FHA domain-containing protein. (299 aa)
syf-1SYF pre-mRNA splicing factor homolog. (855 aa)
plrg-1WD_REPEATS_REGION domain-containing protein. (494 aa)
cdc-5LCell Division Cycle related. (755 aa)
F32B6.3SFM domain-containing protein. (352 aa)
let-858Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa)
F37C12.1Uncharacterized protein. (323 aa)
mog-3Sex determining protein MOG-3. (451 aa)
isy-1Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family. (267 aa)
rnf-113Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents. (384 aa)
mog-1Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1131 aa)
syf-2Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing. (234 aa)
K07C5.6Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family. (647 aa)
M03F8.3Uncharacterized protein. (747 aa)
R08D7.1BUD13 homolog; Belongs to the CWC26 family. (458 aa)
cwc-15Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing. (230 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
rbm-22RNA Binding Motif protein homolog. (408 aa)
skp-1Uncharacterized protein T27F2.1. (535 aa)
cyn-16PPIase cyclophilin-type domain-containing protein. (483 aa)
Y54G2A.12WD_REPEATS_REGION domain-containing protein. (274 aa)
rsr-2Cwf21 domain-containing protein. (425 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]