STRINGSTRING
B0250.5 B0250.5 B0272.3 B0272.3 B0272.4 B0272.4 B0303.3 B0303.3 ivd-1 ivd-1 C05C10.3 C05C10.3 let-721 let-721 acdh-2 acdh-2 dhs-6 dhs-6 acdh-13 acdh-13 ech-1.1 ech-1.1 C32E8.9 C32E8.9 acs-19 acs-19 pks-1 pks-1 dhs-18 dhs-18 acs-17 acs-17 acox-1.5 acox-1.5 C50D2.9 C50D2.9 acs-21 acs-21 acdh-1 acdh-1 maoc-1 maoc-1 acdh-12 acdh-12 ech-8 ech-8 ech-9 ech-9 F02A9.10 F02A9.10 F02C12.2 F02C12.2 acox-1.1 acox-1.1 acox-1.2 acox-1.2 acox-1.3 acox-1.3 acox-1.4 acox-1.4 dhs-25 dhs-25 hach-1 hach-1 F10G8.9 F10G8.9 acs-14 acs-14 alh-8 alh-8 F23C8.5 F23C8.5 acs-12 acs-12 F27D4.1 F27D4.1 lsy-22 lsy-22 bckd-1B bckd-1B acdh-9 acdh-9 acs-2 acs-2 mccc-1 mccc-1 fasn-1 fasn-1 F32H2.6 F32H2.6 mlcd-1 mlcd-1 F37C12.3 F37C12.3 acs-4 acs-4 ppt-1 ppt-1 acs-16 acs-16 acaa-2 acaa-2 F54C8.1 F54C8.1 ech-5 ech-5 acox-3 acox-3 acox-1.6 acox-1.6 bcat-1 bcat-1 sur-5 sur-5 acdh-3 acdh-3 acds-10 acds-10 dhs-28 dhs-28 dhs-15 dhs-15 ech-4 ech-4 acs-15 acs-15 cpt-2 cpt-2 hacd-1 hacd-1 acs-18 acs-18 R17.3 R17.3 T02G5.7 T02G5.7 kat-1 kat-1 T04G9.4 T04G9.4 ech-6 ech-6 alh-5 alh-5 acs-3 acs-3 ech-1.2 ech-1.2 acdh-10 acdh-10 acdh-4 acdh-4 acdh-7 acdh-7 T28H10.1 T28H10.1 W03F9.4 W03F9.4 pod-2 pod-2 W09D6.1 W09D6.1 mecr-1 mecr-1 ech-7 ech-7 hphd-1 hphd-1 dhs-11 dhs-11 bckd-1A bckd-1A Y43F4A.4 Y43F4A.4 acdh-11 acdh-11 cpt-1 cpt-1 Y48A6B.9 Y48A6B.9 daf-22 daf-22 acs-13 acs-13 Y71G12B.10 Y71G12B.10 acs-5 acs-5 ZK112.5 ZK112.5 ZK112.6 ZK112.6 dbt-1 dbt-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0250.5Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. (299 aa)
B0272.3Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (309 aa)
B0272.4Uncharacterized protein B0272.4. (255 aa)
B0303.3Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
ivd-1Isovaleryl-CoA dehydrogenase. (419 aa)
C05C10.3Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (521 aa)
let-721Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (597 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
dhs-6SCP2 domain-containing protein. (418 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
ech-1.1Enoyl-CoA Hydratase. (755 aa)
C32E8.9Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (268 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
pks-1PolyKetide Synthase. (7752 aa)
dhs-18DeHydrogenases, Short chain. (293 aa)
acs-17Fatty Acid CoA Synthetase family. (718 aa)
acox-1.5Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa)
C50D2.9PKS_AT domain-containing protein. (405 aa)
acs-21Fatty Acid CoA Synthetase family. (517 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
ech-8Enoyl-CoA Hydratase. (437 aa)
ech-9Enoyl-CoA Hydratase. (434 aa)
F02A9.10Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family. (608 aa)
F02C12.2Uncharacterized protein. (278 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
acox-1.2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
acox-1.3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
acox-1.4Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
dhs-25DeHydrogenases, Short chain. (248 aa)
hach-13-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
F10G8.9PKS_KS domain-containing protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (403 aa)
acs-14Fatty Acid CoA Synthetase family. (544 aa)
alh-8Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family. (523 aa)
F23C8.5ETF domain-containing protein. (255 aa)
acs-12Fatty Acid CoA Synthetase family. (550 aa)
F27D4.1Probable electron transfer flavoprotein subunit alpha, mitochondrial; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (332 aa)
lsy-22Uncharacterized protein. (293 aa)
bckd-1BTransket_pyr domain-containing protein. (366 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
mccc-1MethylCrotonoyl-Coenzyme A Carboxylase (Alpha). (671 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
F32H2.6Ketoacyl_synth_N domain-containing protein. (187 aa)
mlcd-1MaLonyl CoA Decarboxylase. (442 aa)
F37C12.3Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (145 aa)
acs-4Fatty Acid CoA Synthetase family. (731 aa)
ppt-1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
acs-16AMP-binding domain-containing protein. (569 aa)
acaa-2ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
F54C8.1Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (298 aa)
ech-5Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (287 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
acox-1.6Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
bcat-1Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
sur-5Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family. (700 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
acds-10ACaD (ACAD, acyl-CoA Dehydrogenase) Sequence homolog. (985 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
dhs-15DeHydrogenases, Short chain. (278 aa)
ech-4ACB domain-containing protein. (385 aa)
acs-15Fatty Acid CoA Synthetase family. (703 aa)
cpt-2Calponin-homology (CH) domain-containing protein. (646 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
acs-18AMP-binding domain-containing protein. (700 aa)
R17.3SMB domain-containing protein. (440 aa)
T02G5.7Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
kat-1Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
T04G9.4ACPS domain-containing protein. (297 aa)
ech-6Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
alh-5Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa)
acs-3AMP-binding domain-containing protein. (653 aa)
ech-1.2Enoyl-CoA Hydratase. (781 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
T28H10.1ACPS domain-containing protein. (285 aa)
W03F9.4Carn_acyltransf domain-containing protein. (746 aa)
pod-2Uncharacterized protein. (2165 aa)
W09D6.1AMP-binding domain-containing protein. (889 aa)
mecr-1Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (344 aa)
ech-7Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
hphd-1Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (465 aa)
dhs-11DeHydrogenases, Short chain. (244 aa)
bckd-1A2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). (432 aa)
Y43F4A.42-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (105 aa)
acdh-11Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. (617 aa)
cpt-1Carnitine Palmitoyl Transferase; Belongs to the carnitine/choline acetyltransferase family. (779 aa)
Y48A6B.9Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (346 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
acs-13AMP-binding domain-containing protein. (726 aa)
Y71G12B.10Pyruvate carboxyltransferase domain-containing protein. (318 aa)
acs-5Fatty Acid CoA Synthetase family. (687 aa)
ZK112.5Uncharacterized protein ZK112.5. (159 aa)
ZK112.6Uncharacterized protein ZK112.6. (149 aa)
dbt-12-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] (448 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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