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B0250.5 B0250.5 B0272.3 B0272.3 B0303.3 B0303.3 C05C10.3 C05C10.3 let-721 let-721 dhs-6 dhs-6 acdh-13 acdh-13 ech-1.1 ech-1.1 C32E8.9 C32E8.9 acs-19 acs-19 acox-1.5 acox-1.5 acdh-1 acdh-1 maoc-1 maoc-1 acdh-12 acdh-12 ech-8 ech-8 ech-9 ech-9 acox-1.1 acox-1.1 acox-1.2 acox-1.2 acox-1.3 acox-1.3 acox-1.4 acox-1.4 hach-1 hach-1 alh-8 alh-8 F23C8.5 F23C8.5 F27D4.1 F27D4.1 lsy-22 lsy-22 acdh-9 acdh-9 acaa-2 acaa-2 F54C8.1 F54C8.1 acox-3 acox-3 acox-1.6 acox-1.6 sur-5 sur-5 acdh-3 acdh-3 acds-10 acds-10 dhs-28 dhs-28 ech-4 ech-4 cpt-2 cpt-2 hacd-1 hacd-1 T02G5.7 T02G5.7 kat-1 kat-1 ech-6 ech-6 alh-5 alh-5 ech-1.2 ech-1.2 acdh-10 acdh-10 acdh-4 acdh-4 acdh-7 acdh-7 ech-7 ech-7 hphd-1 hphd-1 daf-22 daf-22
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0250.5Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. (299 aa)
B0272.3Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (309 aa)
B0303.3Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
C05C10.3Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (521 aa)
let-721Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (597 aa)
dhs-6SCP2 domain-containing protein. (418 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
ech-1.1Enoyl-CoA Hydratase. (755 aa)
C32E8.9Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (268 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
acox-1.5Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
ech-8Enoyl-CoA Hydratase. (437 aa)
ech-9Enoyl-CoA Hydratase. (434 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
acox-1.2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
acox-1.3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
acox-1.4Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
hach-13-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
alh-8Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family. (523 aa)
F23C8.5ETF domain-containing protein. (255 aa)
F27D4.1Probable electron transfer flavoprotein subunit alpha, mitochondrial; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (332 aa)
lsy-22Uncharacterized protein. (293 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
acaa-2ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
F54C8.1Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (298 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
acox-1.6Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
sur-5Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family. (700 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
acds-10ACaD (ACAD, acyl-CoA Dehydrogenase) Sequence homolog. (985 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
ech-4ACB domain-containing protein. (385 aa)
cpt-2Calponin-homology (CH) domain-containing protein. (646 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
T02G5.7Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
kat-1Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
ech-6Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
alh-5Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa)
ech-1.2Enoyl-CoA Hydratase. (781 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
ech-7Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
hphd-1Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (465 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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