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| | B0001.4 | Probable uridine-cytidine kinase; Belongs to the uridine kinase family. (248 aa) |
| | B0228.7 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (288 aa) |
| | pacs-1 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. (423 aa) |
| | rnr-2 | Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (381 aa) |
| | C06G3.5 | A_deaminase domain-containing protein. (391 aa) |
| | dpyd-1 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil. (1059 aa) |
| | C25G4.8 | Uncharacterized protein. (394 aa) |
| | let-754 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (251 aa) |
| | C29F7.3 | UMP-CMP kinase 1; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa) |
| | cytb-5.1 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (134 aa) |
| | ampd-1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (948 aa) |
| | adss-1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (457 aa) |
| | C47B2.2 | Uncharacterized protein. (231 aa) |
| | cdd-1 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa) |
| | dhp-2 | Dihydropyrimidinase 2; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (520 aa) |
| | C51E3.6 | Uncharacterized protein. (555 aa) |
| | atic-1 | MGS domain-containing protein. (594 aa) |
| | D2023.1 | Cytochrome b5 heme-binding domain-containing protein. (337 aa) |
| | pyr-1 | Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. (2198 aa) |
| | pde-3 | Probable 3',5'-cyclic phosphodiesterase pde-3. (693 aa) |
| | E02H1.6 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. (182 aa) |
| | apy-1 | Apyrase apy-1; Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response. (355 aa) |
| | F09E5.3 | Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (303 aa) |
| | pfas-1 | Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1324 aa) |
| | F13H8.12 | MSP domain-containing protein. (128 aa) |
| | F13H8.3 | IU_nuc_hydro domain-containing protein. (374 aa) |
| | upb-1 | CN hydrolase domain-containing protein. (387 aa) |
| | F14D7.1 | Uncharacterized protein. (176 aa) |
| | F19B6.1 | Uridine kinase; Belongs to the uridine kinase family. (569 aa) |
| | F25B5.3 | Putative cytosolic 5'-nucleotidase 3. (376 aa) |
| | ndk-1 | Nucleoside diphosphate kinase; Belongs to the NDK family. (153 aa) |
| | F32D1.5 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa) |
| | F38B2.4 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | F38B6.4 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (975 aa) |
| | F40F8.1 | UMP-CMP kinase 2; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | eas-1 | Probable Golgi transport protein 1; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. (141 aa) |
| | F44E2.8 | Uncharacterized protein F44E2.8. (308 aa) |
| | F45F2.9 | HD domain-containing protein. (187 aa) |
| | cdd-2 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (166 aa) |
| | F58B4.2 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (89 aa) |
| | JC8.4 | CMP/dCMP-type deaminase domain-containing protein. (176 aa) |
| | K01G5.10 | Uncharacterized protein. (248 aa) |
| | K02D7.1 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (318 aa) |
| | dut-1 | Deoxyuridinetriphosphatase. (491 aa) |
| | uda-1 | Nucleoside-diphosphatase uda-1; Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum; Belongs to the GDA1/CD39 NTPase family. (479 aa) |
| | gmps-1 | Probable GMP synthase [glutamine-hydrolyzing]. (745 aa) |
| | R05G6.5 | Uncharacterized protein. (188 aa) |
| | dhp-1 | Dihydropyrimidinase 1. (489 aa) |
| | adsl-1 | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. (478 aa) |
| | mig-23 | Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. (552 aa) |
| | R07H5.8 | PfkB domain-containing protein. (342 aa) |
| | R11E3.2 | Uncharacterized protein. (546 aa) |
| | R12E2.11 | Orotate phosphoribosyltransferase; Phosphoribosyltransferase which catalyzes the formation of UMP from uracil in vitro and thus may be involved in UMP biosynthesis via the salvage pathway. May also participate in the first step of UMP synthesis by catalyzing the formation of orotidine 5'-phosphate, a UMP precursor, from orotate. (227 aa) |
| | R13A5.10 | CMP/dCMP-type deaminase domain-containing protein. (153 aa) |
| | dtmk-1 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. (218 aa) |
| | guk-1 | Guanylate kinase-like domain-containing protein. (216 aa) |
| | ppat-1 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa) |
| | T05H4.4 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (303 aa) |
| | hpo-19 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (309 aa) |
| | umps-1 | Orotidine 5'-phosphate decarboxylase; Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. In the C-terminal section; belongs to the OMP decarboxylase family. (497 aa) |
| | T07G12.2 | Uncharacterized protein. (544 aa) |
| | T07G12.4 | Uncharacterized protein. (550 aa) |
| | T16A9.3 | BTB domain-containing protein. (343 aa) |
| | T19B4.3 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa) |
| | T22D1.3 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (534 aa) |
| | rnr-1 | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (788 aa) |
| | cytb-5.2 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (141 aa) |
| | dhod-1 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (411 aa) |
| | W03D8.7 | Uncharacterized protein. (176 aa) |
| | hprt-1 | Hypoxanthine phosphoribosyltransferase. (214 aa) |
| | Y10G11A.1 | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (301 aa) |
| | unc-33 | Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] (854 aa) |
| | thk-1 | Thymidine kinase. (269 aa) |
| | Y43F8C.13 | IU_nuc_hydro domain-containing protein. (338 aa) |
| | Y47D3A.14 | CMP/dCMP-type deaminase domain-containing protein. (287 aa) |
| | Y47D3A.34 | Uncharacterized protein. (345 aa) |
| | Y48A6B.7 | CMP/dCMP-type deaminase domain-containing protein. (168 aa) |
| | Y52B11A.3 | Uncharacterized protein. (552 aa) |
| | Y59E9AL.4 | Uncharacterized protein. (555 aa) |
| | hap-1 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa) |
| | ZK563.7 | Uncharacterized protein. (349 aa) |
| | ZK643.2 | Probable deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. (197 aa) |
| | ZK673.2 | Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family. (222 aa) |
| | upp-1 | Uridine and thymidine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan ; Belongs to the PNP/UDP phosphorylase family. (295 aa) |
| | ZK909.3 | HD domain-containing protein. (229 aa) |
