STRINGSTRING
B0001.4 B0001.4 B0228.7 B0228.7 pacs-1 pacs-1 rnr-2 rnr-2 C06G3.5 C06G3.5 C25G4.8 C25G4.8 let-754 let-754 C29F7.3 C29F7.3 ampd-1 ampd-1 adss-1 adss-1 C47B2.2 C47B2.2 cdd-1 cdd-1 atic-1 atic-1 pde-3 pde-3 E02H1.6 E02H1.6 apy-1 apy-1 F09E5.3 F09E5.3 pfas-1 pfas-1 F13H8.12 F13H8.12 F14D7.1 F14D7.1 F19B6.1 F19B6.1 F25B5.3 F25B5.3 ndk-1 ndk-1 F32D1.5 F32D1.5 F38B2.4 F38B2.4 F38B6.4 F38B6.4 F40F8.1 F40F8.1 F44E2.8 F44E2.8 F45F2.9 F45F2.9 cdd-2 cdd-2 JC8.4 JC8.4 K02D7.1 K02D7.1 dut-1 dut-1 uda-1 uda-1 gmps-1 gmps-1 R05G6.5 R05G6.5 adsl-1 adsl-1 mig-23 mig-23 R07H5.8 R07H5.8 R13A5.10 R13A5.10 dtmk-1 dtmk-1 guk-1 guk-1 ppat-1 ppat-1 T16A9.3 T16A9.3 T19B4.3 T19B4.3 T22D1.3 T22D1.3 rnr-1 rnr-1 W03D8.7 W03D8.7 hprt-1 hprt-1 Y10G11A.1 Y10G11A.1 thk-1 thk-1 Y43F8C.13 Y43F8C.13 Y47D3A.14 Y47D3A.14 Y47D3A.34 Y47D3A.34 Y48A6B.7 Y48A6B.7 hap-1 hap-1 ZK563.7 ZK563.7 ZK643.2 ZK643.2 ZK673.2 ZK673.2 upp-1 upp-1 ZK909.3 ZK909.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0001.4Probable uridine-cytidine kinase; Belongs to the uridine kinase family. (248 aa)
B0228.7S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (288 aa)
pacs-1Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. (423 aa)
rnr-2Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (381 aa)
C06G3.5A_deaminase domain-containing protein. (391 aa)
C25G4.8Uncharacterized protein. (394 aa)
let-754Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (251 aa)
C29F7.3UMP-CMP kinase 1; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
ampd-1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (948 aa)
adss-1Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (457 aa)
C47B2.2Uncharacterized protein. (231 aa)
cdd-1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa)
atic-1MGS domain-containing protein. (594 aa)
pde-3Probable 3',5'-cyclic phosphodiesterase pde-3. (693 aa)
E02H1.6Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. (182 aa)
apy-1Apyrase apy-1; Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response. (355 aa)
F09E5.3Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (303 aa)
pfas-1Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1324 aa)
F13H8.12MSP domain-containing protein. (128 aa)
F14D7.1Uncharacterized protein. (176 aa)
F19B6.1Uridine kinase; Belongs to the uridine kinase family. (569 aa)
F25B5.3Putative cytosolic 5'-nucleotidase 3. (376 aa)
ndk-1Nucleoside diphosphate kinase; Belongs to the NDK family. (153 aa)
F32D1.5GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa)
F38B2.4Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
F38B6.4Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (975 aa)
F40F8.1UMP-CMP kinase 2; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
F44E2.8Uncharacterized protein F44E2.8. (308 aa)
F45F2.9HD domain-containing protein. (187 aa)
cdd-2Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (166 aa)
JC8.4CMP/dCMP-type deaminase domain-containing protein. (176 aa)
K02D7.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (318 aa)
dut-1Deoxyuridinetriphosphatase. (491 aa)
uda-1Nucleoside-diphosphatase uda-1; Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum; Belongs to the GDA1/CD39 NTPase family. (479 aa)
gmps-1Probable GMP synthase [glutamine-hydrolyzing]. (745 aa)
R05G6.5Uncharacterized protein. (188 aa)
adsl-1Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. (478 aa)
mig-23Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. (552 aa)
R07H5.8PfkB domain-containing protein. (342 aa)
R13A5.10CMP/dCMP-type deaminase domain-containing protein. (153 aa)
dtmk-1Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. (218 aa)
guk-1Guanylate kinase-like domain-containing protein. (216 aa)
ppat-1Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa)
T16A9.3BTB domain-containing protein. (343 aa)
T19B4.3Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa)
T22D1.3Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (534 aa)
rnr-1Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (788 aa)
W03D8.7Uncharacterized protein. (176 aa)
hprt-1Hypoxanthine phosphoribosyltransferase. (214 aa)
Y10G11A.15'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (301 aa)
thk-1Thymidine kinase. (269 aa)
Y43F8C.13IU_nuc_hydro domain-containing protein. (338 aa)
Y47D3A.14CMP/dCMP-type deaminase domain-containing protein. (287 aa)
Y47D3A.34Uncharacterized protein. (345 aa)
Y48A6B.7CMP/dCMP-type deaminase domain-containing protein. (168 aa)
hap-1Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
ZK563.7Uncharacterized protein. (349 aa)
ZK643.2Probable deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. (197 aa)
ZK673.2Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family. (222 aa)
upp-1Uridine and thymidine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan ; Belongs to the PNP/UDP phosphorylase family. (295 aa)
ZK909.3HD domain-containing protein. (229 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.