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pacs-1 pacs-1 C06G3.5 C06G3.5 ampd-1 ampd-1 adss-1 adss-1 atic-1 atic-1 pde-3 pde-3 pfas-1 pfas-1 F25B5.3 F25B5.3 F32D1.5 F32D1.5 F38B6.4 F38B6.4 K02D7.1 K02D7.1 gmps-1 gmps-1 adsl-1 adsl-1 R07H5.8 R07H5.8 ppat-1 ppat-1 T19B4.3 T19B4.3 T22D1.3 T22D1.3 hprt-1 hprt-1 Y10G11A.1 Y10G11A.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pacs-1Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. (423 aa)
C06G3.5A_deaminase domain-containing protein. (391 aa)
ampd-1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (948 aa)
adss-1Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (457 aa)
atic-1MGS domain-containing protein. (594 aa)
pde-3Probable 3',5'-cyclic phosphodiesterase pde-3. (693 aa)
pfas-1Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1324 aa)
F25B5.3Putative cytosolic 5'-nucleotidase 3. (376 aa)
F32D1.5GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (358 aa)
F38B6.4Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (975 aa)
K02D7.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (318 aa)
gmps-1Probable GMP synthase [glutamine-hydrolyzing]. (745 aa)
adsl-1Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. (478 aa)
R07H5.8PfkB domain-containing protein. (342 aa)
ppat-1Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa)
T19B4.3Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa)
T22D1.3Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (534 aa)
hprt-1Hypoxanthine phosphoribosyltransferase. (214 aa)
Y10G11A.15'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (301 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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