Your Input: | |
| | eri-12 | Enhanced RNAI (RNA interference). (674 aa) |
| | B0025.4 | Uncharacterized protein. (148 aa) |
| | his-45 | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | his-47 | Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa) |
| | his-48 | Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) |
| | his-46 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | C06A5.3 | PWWP domain-containing protein. (783 aa) |
| | hda-2 | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] (507 aa) |
| | arp-6 | Actin-like protein C08B11.6; Belongs to the actin family. ARP6 subfamily. (418 aa) |
| | wdr-5.1 | WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] (376 aa) |
| | C16A11.4 | SPK domain-containing protein. (527 aa) |
| | C17E4.6 | YL1_C domain-containing protein. (391 aa) |
| | dcp-66 | Deacetylase Complex Protein. (724 aa) |
| | set-2 | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa) |
| | mbd-2 | MBD_C domain-containing protein. (210 aa) |
| | ruvb-1 | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...] (476 aa) |
| | set-4 | Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway. (288 aa) |
| | swd-2.1 | WD_REPEATS_REGION domain-containing protein. (322 aa) |
| | mys-4 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (617 aa) |
| | sumv-1 | Protein sumv-1; Nuclear factor that influences the activity of genes involved in vulval development. (1024 aa) |
| | hda-11 | Hist_deacetyl domain-containing protein. (334 aa) |
| | C41G11.1 | Metallophos domain-containing protein. (429 aa) |
| | met-1 | Histone-lysine N-methyltransferase. (1604 aa) |
| | C43H6.4 | Uncharacterized protein. (627 aa) |
| | athp-1 | AT Hook plus PHD finger transcription factor. (1150 aa) |
| | trr-1 | Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. (4064 aa) |
| | his-35 | Histone H2A; Belongs to the histone H2A family. (127 aa) |
| | his-41 | Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) |
| | his-37 | Histone H4. (103 aa) |
| | hda-1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] (461 aa) |
| | zhit-1 | HIT-type domain-containing protein. (194 aa) |
| | D1014.4 | Uncharacterized protein. (180 aa) |
| | spr-1 | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. (558 aa) |
| | utx-1 | UTX (Ubiquitously transcribed TPR on X) homolog. (1146 aa) |
| | nap-1 | Nucleosome Assembly Protein; Belongs to the nucleosome assembly protein (NAP) family. (316 aa) |
| | set-8 | SET domain-containing protein. (512 aa) |
| | sin-3 | Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa) |
| | his-51 | Histone H2A. (127 aa) |
| | his-54 | Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) |
| | his-53 | Histone H2A. (127 aa) |
| | his-52 | Histone H2B 2. (123 aa) |
| | his-49 | Histone H3. (136 aa) |
| | his-50 | Histone H4. (103 aa) |
| | his-44 | Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa) |
| | his-43 | Histone H2A. (127 aa) |
| | his-42 | Histone H3. (136 aa) |
| | phf-31 | PHD domain-containing protein. (168 aa) |
| | F17A2.16 | Uncharacterized protein. (322 aa) |
| | his-32 | Histone H3. (136 aa) |
| | his-31 | Histone H4. (103 aa) |
| | his-33 | Histone H2A. (127 aa) |
| | his-34 | Histone H2B 1. (122 aa) |
| | phf-34 | PHD-type domain-containing protein. (246 aa) |
| | rbbp-5 | Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. (454 aa) |
| | his-64 | Histone H4. (103 aa) |
| | his-63 | Histone H3. (136 aa) |
| | let-418 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa) |
| | nurf-1 | Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa) |
| | his-30 | Histone H2A. (127 aa) |
| | his-29 | Histone H2B 1. (122 aa) |
| | F39H11.1 | BCNT-C domain-containing protein. (224 aa) |
| | hda-6 | Histone deacetylase 6; Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (957 aa) |
| | lin-49 | Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1042 aa) |
| | hda-5 | Hist_deacetyl domain-containing protein. (508 aa) |
| | F43G6.17 | Hist_deacetyl domain-containing protein. (281 aa) |
| | F43G6.4 | Uncharacterized protein. (270 aa) |
| | his-71 | Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central [...] (136 aa) |
| | his-6 | Histone H3. (136 aa) |
| | his-39 | Histone domain-containing protein; Belongs to the histone H2B family. (67 aa) |
| | his-5 | Histone H4. (103 aa) |
| | his-7 | Histone H2A. (127 aa) |
| | ctbp-1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. (727 aa) |
| | cfp-1 | Zf-CpG_bind_C domain-containing protein. (508 aa) |
| | str-79 | Seven TM Receptor. (314 aa) |
| | cpar-1 | Histone H3-like centromeric protein cpar-1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. (261 aa) |
| | sumv-2 | Protein sumv-2; Influences the activity of genes involved in vulval development. (1145 aa) |
| | his-55 | Histone H3. (136 aa) |
| | his-56 | Histone H4. (103 aa) |
| | his-58 | Probable histone H2B 4. (123 aa) |
| | cir-1 | Cir_N domain-containing protein. (560 aa) |
| | his-61 | Histone H2A. (127 aa) |
| | his-60 | Histone H4. (103 aa) |
| | his-59 | Histone H3. (136 aa) |
| | his-62 | Probable histone H2B 4. (123 aa) |
| | his-65 | Histone H2A. (127 aa) |
| | H04D03.6 | Uncharacterized protein. (94 aa) |
| | H05L14.2 | RING-type domain-containing protein. (1624 aa) |
| | chd-1 | Chromodomain and Helicase Domain protein. (1461 aa) |
| | mcrs-1 | FHA domain-containing protein. (478 aa) |
| | his-40 | Histone H3. (136 aa) |
| | his-38 | Histone H4. (103 aa) |
| | mys-2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (533 aa) |
| | wdr-5.2 | WD repeat-containing protein wdr-5.2; Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'. (395 aa) |
| | his-18 | Histone H4. (103 aa) |
| | his-19 | Histone H2A. (127 aa) |
| | his-22 | Histone H2B 2. (123 aa) |
| | his-27 | Histone H3. (136 aa) |
| | his-28 | Histone H4. (103 aa) |
| | his-21 | Histone H2A. (127 aa) |
| | his-20 | Histone H2B 2. (123 aa) |
| | his-17 | Histone H3. (136 aa) |
| | lin-53 | Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] (417 aa) |
| | phf-33 | PHD-type domain-containing protein. (650 aa) |
| | set-12 | Histone-lysine N-methyltransferase. (389 aa) |
| | hat-1 | Hat1_N domain-containing protein. (411 aa) |
| | gfl-1 | GAS41-Like. (211 aa) |
| | hda-3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa) |
| | lsy-12 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1585 aa) |
| | htz-1 | Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...] (140 aa) |
| | T05A12.4 | Uncharacterized protein. (1622 aa) |
| | lsy-13 | PHD domain-containing protein. (247 aa) |
| | lsd-1 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa) |
| | his-4 | Histone H2B 2. (123 aa) |
| | his-2 | Histone H3. (136 aa) |
| | his-1 | Histone H4. (103 aa) |
| | set-16 | Histone-lysine N-methyltransferase. (2475 aa) |
| | cec-6 | Chromo domain-containing protein. (891 aa) |
| | lin-59 | Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa) |
| | pis-1 | PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. (1076 aa) |
| | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa) |
| | ruvb-2 | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development. Involved in the en [...] (448 aa) |
| | his-67 | Histone H4. (103 aa) |
| | his-68 | Histone H2A. (127 aa) |
| | T23F6.1 | Uncharacterized protein. (160 aa) |
| | T24C4.2 | Uncharacterized protein. (423 aa) |
| | set-1 | Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. (242 aa) |
| | str-81 | Seven TM Receptor. (365 aa) |
| | lin-40 | Uncharacterized protein. (1022 aa) |
| | mys-1 | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. (458 aa) |
| | his-73 | Histone domain-containing protein. (46 aa) |
| | Y104H12D.4 | Uncharacterized protein. (107 aa) |
| | ekl-4 | Uncharacterized protein. (488 aa) |
| | Y105E8B.7 | Uncharacterized protein. (269 aa) |
| | epc-1 | Enhancer of PolyComb-like. (795 aa) |
| | ssl-1 | Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2395 aa) |
| | bet-1 | Bromodomain-containing protein bet-1; Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. I [...] (853 aa) |
| | ash-2 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa) |
| | cec-7 | C.Elegans Chromodomain protein. (499 aa) |
| | mrg-1 | MRG domain-containing protein. (337 aa) |
| | Y43F4B.10 | Uncharacterized protein. (108 aa) |
| | Y43F8B.12 | Uncharacterized protein. (167 aa) |
| | ing-3 | Inhibitor of growth protein. (490 aa) |
| | hda-10 | Hist_deacetyl domain-containing protein. (517 aa) |
| | Y53G8AM.6 | Uncharacterized protein. (183 aa) |
| | cec-8 | Chromo domain-containing protein. (679 aa) |
| | cutl-26 | ZP domain-containing protein. (502 aa) |
| | Y73B3A.13 | annotation not available (418 aa) |
| | Y75B8A.6 | Uncharacterized protein. (447 aa) |
| | wdr-5.3 | WD repeat-containing protein wdr-5.3; Not required for methylation of histone H3 'Lys-4'. Belongs to the WD repeat WDR5/wds family. (501 aa) |
| | ZK1127.3 | Uncharacterized protein. (206 aa) |
| | his-26 | Histone H4. (103 aa) |
| | his-16 | Histone H2A. (127 aa) |
| | his-9 | Histone H3. (136 aa) |
| | his-10 | Histone H4. (103 aa) |
| | his-12 | Histone H2A. (127 aa) |
| | his-13 | Histone H3. (136 aa) |
| | his-14 | Histone H4. (103 aa) |
| | his-15 | Histone H2B 1. (122 aa) |
| | ZK1320.11 | Uncharacterized protein. (250 aa) |
| | dpy-30 | Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (123 aa) |
| | cec-10 | C.Elegans Chromodomain protein. (865 aa) |
